The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
The impact of ageing on natural killer cell function and potential consequences for health in older adults
Open accessAbstract
Forming the first line of defence against virally infected and malignant cells, natural killer (NK) cells are critical effector cells of the innate immune system. With age, significant impairments have been reported in the two main mechanisms by which NK cells confer host protection: direct cytotoxicity and the secretion of immunoregulatory cytokines and chemokines. In elderly subjects, decreased NK cell activity has been shown to be associated with an increased incidence and severity of viral infection, highlighting the clinical implications that age-associated changes in NK cell biology have on the health of older adults. However, is an increased susceptibility to viral infection the only consequence of these age-related changes in NK cell function? Recently, evidence has emerged that has shown that in addition to eliminating transformed cells, NK cells are involved in many other biological processes such as immune regulation, anti-microbial immune responses and the recognition and elimination of senescent cells, novel functions that involve NK-mediated cytotoxicity and/or cytokine production. Thus, the decrease in NK cell function that accompanies physiological ageing is likely to have wider implications for the health of older adults than originally thought. Here, we give a detailed description of the changes in NK cell biology that accompany human ageing and propose that certain features of the ageing process such as: (i) the increased reactivation rates of latent Mycobacterium tuberculosis, (ii) the slower resolution of inflammatory responses and (iii) the increased incidence of bacterial and fungal infection are attributable in part to an age-associated decline in NK cell function.
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Cites
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
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Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
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Senescence of Activated Stellate Cells Limits Liver Fibrosis
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Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
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Human NK cells display major phenotypic and functional changes over the life span
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“…et al., 2011; Hazeldine et al., 2012; arazona et al., 2012), which in the case of NKp30 is accompanied by reduction in its surface density (Tarazona et al., 2012), others have emonstrated no effect for age on the proportions of NK cells bearng these receptors (Le Garff-Tavernier et al., 2010).”
InfluentialGranule exocytosis mediates immune surveillance of senescent cells
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Cited by
Immune function and micronutrient requirements change over the life course
Maggini, S., Pierre, A., & Calder, P. C. (2018) · Nutrients · doi:10.3390/nu10101531 · Cited by 710
Impaired immune surveillance accelerates accumulation of senescent cells and aging
Ovadya, Y., Landsberger, T., Leins, H., Vadai, E., Gal, H., Biran, A., Yosef, R., Sagiv, A., Agrawal, A., Shapira, A., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07825-3 · Cited by 578
Immunosenescence and inflammaging in the aging process: age-related diseases or longevity?
Santoro, A., Bientinesi, E., & Monti, D. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101422 · Cited by 603
Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition
Pereira, B. I., Devine, O. P., Vukmanovic-Stejic, M., Chambers, E. S., Subramanian, P., Patel, N., Virasami, A., Sebire, N. J., Kinsler, V., Valdovinos, A., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10335-5 · Cited by 556
The immune system and aging: A review
Castelo-Branco, C., & Soveral, I. (2014) · Gynecological Endocrinology · doi:10.3109/09513590.2013.852531 · Cited by 449
Metadata
- Authors
- Hazeldine, J., & Lord, J. M.
- Venue
- Ageing Research Reviews
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 12
- Issue
- 4
- Pages
- 1069-1078
- ISSN
- 1568-1637 (ISSN-L)
- OpenAlex
- W1989383140
- Cited by
- 308
- References
- 9
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- hybrid
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