Immunosenescence and inflammaging in the aging process: age-related diseases or longevity?

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

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Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

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The Hallmarks of Aging

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A human gut microbial gene catalogue established by metagenomic sequencing

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Immunobiology of Dendritic Cells

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Sex differences in immune responses

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Inflamm‐aging: An Evolutionary Perspective on Immunosenescence

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Chronic inflammation in the etiology of disease across the life span

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Cellular senescence: when bad things happen to good cells

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Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

Franceschi, C., & Campisi, J. (2014) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu057 · Cited by 3,891 · see citing works

Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty

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Inflammaging: a new immune–metabolic viewpoint for age-related diseases

Franceschi, C., Garagnani, P., Parini, P., Giuliani, C., & Santoro, A. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0059-4 · Cited by 3,586 · see citing works

Differentiation of Effector CD4 T Cell Populations

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Gut microbiota composition correlates with diet and health in the elderly

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The World Report on Ageing and Health

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Geroscience: Linking Aging to Chronic Disease

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Human nutrition, the gut microbiome and the immune system

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Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans

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Composition, variability, and temporal stability of the intestinal microbiota of the elderly

Claesson, M. J., Cusack, S., O'Sullivan, O., Greene-Diniz, R., de Weerd, H., Flannery, E., Marchesi, J. R., Falush, D., Dinan, T., Fitzgerald, G., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000097107 · Cited by 1,754 · see citing works

Neutrophil Function: From Mechanisms to Disease

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Age-related changes in gut microbiota composition from newborn to centenarian: a cross-sectional study

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World report on ageing and health

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Through Ageing, and Beyond: Gut Microbiota and Inflammatory Status in Seniors and Centenarians

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Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?

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Dietary factors and low-grade inflammation in relation to overweight and obesity

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Gut Microbiota and Extreme Longevity

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Aging in COVID-19: Vulnerability, immunity and intervention

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Inflammaging and ‘Garb-aging’

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Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age

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Mediterranean Diet intervention alters the gut microbiome in older people reducing frailty and improving health status: the NU-AGE 1-year dietary intervention across five European countries

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Undulating changes in human plasma proteome profiles across the lifespan

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Next-generation probiotics: the spectrum from probiotics to live biotherapeutics

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The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates

Franceschi, C., Garagnani, P., Morsiani, C., Conte, M., Santoro, A., Grignolio, A., Monti, D., Capri, M., & Salvioli, S. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00061 · Cited by 945 · see citing works

Post-covid syndrome in individuals admitted to hospital with covid-19: retrospective cohort study

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Diversity and clonal selection in the human T-cell repertoire

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Interleukin-6 in Aging and Chronic Disease: A Magnificent Pathway

Maggio, M. G., Guralnik, J. M., Longo, D. L., & Ferrucci, L. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.6.575 · Cited by 687 · see citing works

Systems analysis of sex differences reveals an immunosuppressive role for testosterone in the response to influenza vaccination

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Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging

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Increased cytokine production in mononuclear cells of healthy elderly people

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Small Intestine Microbiota Regulate Host Digestive and Absorptive Adaptive Responses to Dietary Lipids

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Age and immunity: What is “immunosenescence”?

Pawelec, G. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2017.10.024 · Cited by 606 · see citing works

Sexual-dimorphism in human immune system aging

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Inflammatory Response in the CNS: Friend or Foe?

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An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging

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Innate immunosenescence: Effect of aging on cells and receptors of the innate immune system in humans

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NETosis: Molecular Mechanisms, Role in Physiology and Pathology

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Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response

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Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function

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Fecal microbiota transplantation alleviated Alzheimer’s disease-like pathogenesis in APP/PS1 transgenic mice

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The immunology of exceptional individuals: the lesson of centenarians

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Morbidity Profiles of Centenarians: Survivors, Delayers, and Escapers

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Sex and Gender Differences in the Outcomes of Vaccination over the Life Course

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Biological Versus Chronological Aging

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Human innate immunosenescence: causes and consequences for immunity in old age

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Human immunosenescence: the prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space

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The Effect of Age on Thymic Function

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Reductions in 2020 US life expectancy due to COVID-19 and the disproportionate impact on the Black and Latino populations

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Inflamm‐ageing and lifelong antigenic load as major determinants of ageing rate and longevity

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Longitudinal Studies of Clonally Expanded CD8 T Cells Reveal a Repertoire Shrinkage Predicting Mortality and an Increased Number of Dysfunctional Cytomegalovirus-Specific T Cells in the Very Elderly

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Altered Composition of Gut Microbiota in Depression: A Systematic Review

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The Involution of the Ageing Human Thymic Epithelium is Independent of Puberty

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Effect of age on human neutrophil function

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Akkermansia muciniphila in the Human Gastrointestinal Tract: When, Where, and How?

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NK cells and type 1 innate lymphoid cells: partners in host defense

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The immune system in extreme longevity

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NK cell and DC interactions

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Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages

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Aging and Imaging Assessment of Body Composition: From Fat to Facts

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Vaccination in the elderly: The challenge of immune changes with aging

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Circulating mitochondrial DNA increases with age and is a familiar trait: Implications for “inflamm-aging”

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Aged Gut Microbiota Contributes to Systemical Inflammaging after Transfer to Germ-Free Mice

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COVID-19 and Individual Genetic Susceptibility/Receptivity: Role of ACE1/ACE2 Genes, Immunity, Inflammation and Coagulation. Might the Double X-Chromosome in Females Be Protective against SARS-CoV-2 Compared to the Single X-Chromosome in Males?

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Gut microbiome diversity is associated with sleep physiology in humans

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Aging and the immune system: An overview

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The interplay between immunosenescence and age-related diseases

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The gut microbiota modulates host amino acid and glutathione metabolism in mice

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Next generation probiotics in disease amelioration

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Gut microbiota signatures of longevity

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Ageing of the human metaorganism: the microbial counterpart

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<b> Expansion of cytotoxic CD8 ⁺  CD28 ⁻ T cells in healthy ageing people, including centenarians </b>

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A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals

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From “truly naïve” to “exhausted senescent” T cells: When markers predict functionality

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Age-Associated Defect in Human TLR-1/2 Function

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Naive T Cell Maintenance and Function in Human Aging

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Human NK cells display major phenotypic and functional changes over the life span

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Comprehensive analysis of the fecal microbiota of healthy Japanese adults reveals a new bacterial lineage associated with a phenotype characterized by a high frequency of bowel movements and a lean body type

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Subduction hides high-pressure sources of energy that may feed the deep subsurface biosphere

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Age-dependent modifications of Type 1 and Type 2 cytokines within virgin and memory CD4+ T cells in humans

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Cytomegalovirus persistence and T-cell immunosenescence in people aged fifty and older: a systematic review

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Thymic output and functionality of the IL‐7/IL‐7 receptor system in centenarians: implications for the neolymphogenesis at the limit of human life

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Exploring the complex relations between inflammation and aging (inflamm-aging): anti-inflamm-aging remodelling of inflamm- aging, from robustness to frailty

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Evidence for thymic function in the elderly

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Detection of apoptosis in live cells by MitoTracker? Red CMXRos and SYTO dye flow cytometry

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B cells and immunosenescence: A focus on IgG+IgD−CD27− (DN) B cells in aged humans

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Different contribution of EBV and CMV infections in very long-term carriers to age-related alterations of CD8+ T cells

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The conundrum of human immune system “senescence”

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Naive T cells: The crux of cellular immune aging?

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Effect of the NU-AGE Diet on Cognitive Functioning in Older Adults: A Randomized Controlled Trial

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High TNF-α levels in resting B cells negatively correlate with their response

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Sex Differences in the Blood Transcriptome Identify Robust Changes in Immune Cell Proportions with Aging and Influenza Infection

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“Bridging the Gap” Everything that Could Have Been Avoided If We Had Applied Gender Medicine, Pharmacogenetics and Personalized Medicine in the Gender-Omics and Sex-Omics Era

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Inflammaging, hormesis and the rationale for anti-aging strategies

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Aging and Immune System: An Overview

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The effect of age and gender on cytokine production by human peripheral blood mononuclear cells and markers of bone metabolism

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Gender specificity of altered human immune cytokine profiles in aging

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Allele frequencies of +874T→A single nucleotide polymorphism at the first intron of interferon-γ gene in a group of Italian centenarians

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Trajectories of function and biomarkers with age: the CHS All Stars Study

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Immunosenescence is both functional/adaptive and dysfunctional/maladaptive

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Microbiomes other than the gut: inflammaging and age-related diseases

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The aging transcriptome and cellular landscape of the human lung in relation to SARS-CoV-2

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Comparative analysis of the gut microbiota in centenarians and young adults shows a common signature across genotypically non-related populations

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Metabolic age modelling: the lesson from centenarians

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Lower proportion of naïve peripheral CD8+ T cells and an unopposed pro-inflammatory response to human Cytomegalovirus proteins in vitro are associated with longer survival in very elderly people

Derhovanessian, E., Maier, A. B., Hähnel, K., Zelba, H., de Craen, A. J. M., Roelofs, H., Slagboom, E. P., Westendorp, R. G. J., & Pawelec, G. (2013) · AGE · doi:10.1007/s11357-012-9425-7 · Cited by 102 · see citing works

Neutrophils of Centenarians Show Function Levels Similar to Those of Young Adults

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Human Immunosenescence

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Compositional dynamics of the human intestinal microbiota with aging: Implications for health

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Reductions in 2020 US life expectancy due to COVID-19 and the disproportionate impact on the Black and Latino populationsPreprint

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Decreased susceptibility to oxidative stress-induced apoptosis of peripheral blood mononuclear cells from healthy elderly and centenarians

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Inflammation and aging: signaling pathways and intervention therapies

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Photoaging: UV radiation-induced inflammation and immunosuppression accelerate the aging process in the skin

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The Impact of Immune System Aging on Infectious Diseases

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Role of the Immune System in Aging and Longevity

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VACCINATION TO PROMOTE HEALTH THROUGHOUT LIFE AS A HEALTHY AGING STRATEGY

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Immune Senescence and Vaccination in the Elderly

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Inflammaging in Endemic Areas for Infectious Diseases

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Successful Aging

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