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Cited by 114Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 211 of the 211 references it cites were found in a registry or an index.

When astrocytes become harmful: Functional and inflammatory responses that contribute to Alzheimer's disease

Avila-Muñoz, Evangelina, Arias, Clorinda·2014·Ageing Research Reviews
DOI 10.1016/j.arr.2014.07.004
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Abstract

A growing body of research suggests that astrocytes play roles as contributors to the pathophysiology of Alzheimer's disease (AD). Several lines of evidence propose that activated astrocytes produce and release proinflammatory molecules that may be critical for the generation of amyloid-β peptide (Aβ). However, accumulating evidence indicates that Aβ may activate astrocytes, which leads to an increase in cytokines that has been suggested to be a causative factor in the cognitive dysfunction of AD; thus, a vicious circle may be created. Intrinsic inflammatory mechanisms may provide a regulatory system that is capable of influencing the neuronal microenvironment that affects neuronal survival. In this article, we address the evidence surrounding the interactions of dysfunctional astrocytes with neighboring neurons that may initiate a cascade of events that culminates with neuronal injury and the expression of the hallmark lesions of AD. Comprehensive knowledge of the molecular mechanisms underlying the participation of astrocytes in neurodegeneration could aid the development of therapies to restore proper astrocyte function that can be used in AD patients to prevent or alleviate the progression of the disease in a more efficient and comprehensive manner.

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Crossref · 10.1016/j.arr.2014.07.004

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Research works printed but not linked: 1

  1. Zou, 2010, Glutamine synthetase down-regulation reduces astrocyte protection against glutamate excitotoxicity to neurons, Neurochem. Int., 56, 577, 10.1016/j.neuint.2009.12.021 · DOI · Paper page

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Metadata

Authors
Avila-Muñoz, E., & Arias, C.
Affiliations
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (MX)
Corresponding author
Arias, Clorinda
ORCID
Arias, Clorinda
Venue
Ageing Research Reviews
Publisher
Elsevier BV
Published
2014-11
Volume
18
Pages
29-40
ISSN
1568-1637 (ISSN-L)
DOI
10.1016/j.arr.2014.07.004
OpenAlex
W2017431945
Cited by
114
References
211
Citations by year
2026: 4 · 2025: 9 · 2024: 3 · 2023: 7 · 2022: 3 · 2021: 13 · 2020: 10 · 2019: 6 · 2018: 10 · 2017: 8 · 2016: 19 · 2015: 20 · 2014: 2
FWCI
1.91
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Ageing Research Reviews (publishedVersion)
  • PubMed (publishedVersion)
Funders
CONACYT (166482, 239696)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
astrocytes, Alzheimer's disease, neuroinflammation, amyloid-beta, cytokines, astrocyte-neuron interaction, neurodegeneration, cognitive impairment, neuronal injury, astrocyte dysfunction
MeSH terms
Alzheimer Disease, Animals, Astrocytes, Humans, Inflammation, Neurons, Signal Transduction, Amyloid beta-Peptides, Inflammation Mediators, Paracrine Communication

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