Cited by 114Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology Research

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When astrocytes become harmful: Functional and inflammatory responses that contribute to Alzheimer's disease

Avila-Muñoz, Evangelina, Arias, Clorinda·2014·Ageing Research Reviews

DOI 10.1016/j.arr.2014.07.004

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Abstract

A growing body of research suggests that astrocytes play roles as contributors to the pathophysiology of Alzheimer's disease (AD). Several lines of evidence propose that activated astrocytes produce and release proinflammatory molecules that may be critical for the generation of amyloid-β peptide (Aβ). However, accumulating evidence indicates that Aβ may activate astrocytes, which leads to an increase in cytokines that has been suggested to be a causative factor in the cognitive dysfunction of AD; thus, a vicious circle may be created. Intrinsic inflammatory mechanisms may provide a regulatory system that is capable of influencing the neuronal microenvironment that affects neuronal survival. In this article, we address the evidence surrounding the interactions of dysfunctional astrocytes with neighboring neurons that may initiate a cascade of events that culminates with neuronal injury and the expression of the hallmark lesions of AD. Comprehensive knowledge of the molecular mechanisms underlying the participation of astrocytes in neurodegeneration could aid the development of therapies to restore proper astrocyte function that can be used in AD patients to prevent or alleviate the progression of the disease in a more efficient and comprehensive manner.

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Authors: Avila-Muñoz, E., & Arias, C.
Affiliations: Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (MX)
Corresponding author: Arias, Clorinda
ORCID: Arias, Clorinda
Venue: Ageing Research Reviews
Publisher: Elsevier BV
Published: 2014-11
Volume: 18
Pages: 29-40
ISSN: 1568-1637 (ISSN-L)
DOI: 10.1016/j.arr.2014.07.004
OpenAlex: W2017431945
Cited by: 114
References: 211
Citations by year: 2026: 4 · 2025: 9 · 2024: 3 · 2023: 7 · 2022: 3 · 2021: 13 · 2020: 10 · 2019: 6 · 2018: 10 · 2017: 8 · 2016: 19 · 2015: 20 · 2014: 2
FWCI: 1.91
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Ageing Research Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: CONACYT (166482, 239696)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: astrocytes, Alzheimer's disease, neuroinflammation, amyloid-beta, cytokines, astrocyte-neuron interaction, neurodegeneration, cognitive impairment, neuronal injury, astrocyte dysfunction
MeSH terms: Alzheimer Disease, Animals, Astrocytes, Humans, Inflammation, Neurons, Signal Transduction, Amyloid beta-Peptides, Inflammation Mediators, Paracrine Communication

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When astrocytes become harmful: Functional and inflammatory responses that contribute to Alzheimer's disease

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