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Skeletal muscle regeneration and impact of aging and nutrition
Abstract
After skeletal muscle injury a regeneration process takes place to repair muscle. Skeletal muscle recovery is a highly coordinated process involving cross-talk between immune and muscle cells. It is well known that the physiological activities of both immune cells and muscle stem cells decline with advancing age, thereby blunting the capacity of skeletal muscle to regenerate. The age-related reduction in muscle repair efficiency contributes to the development of sarcopenia, one of the most important factors of disability in elderly people. Preserving muscle regeneration capacity may slow the development of this syndrome. In this context, nutrition has drawn much attention: studies have demonstrated that nutrients such as amino acids, n-3 polyunsaturated fatty acids, polyphenols and vitamin D can improve skeletal muscle regeneration by targeting key functions of immune cells, muscle cells or both. Here we review the process of skeletal muscle regeneration with a special focus on the cross-talk between immune and muscle cells. We address the effect of aging on immune and skeletal muscle cells involved in muscle regeneration. Finally, the mechanisms of nutrient action on muscle regeneration are described, showing that quality of nutrition may help to preserve the capacity for skeletal muscle regeneration with age.
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“On the other hand, chronic inflammation observed during ageing is associated with an increase in pro-inflammatory cytokines (compared to younger individuals) such as TNF-α and IL-6 due to possible dysregulation in immune cell function [59,76].”
From Potential Roles of n-3 PUFAs during Skeletal Muscle Growth and Regeneration (2018) · cites this paper as [76]
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Metadata
- Authors
- Domingues-Faria, C., Vasson, M.-P., Goncalves-Mendes, N., Boirie, Y., & Walrand, S.
- Affiliations
- Université Clermont Auvergne (FR)
- ORCID
- Vasson, Marie-Paule
- Venue
- Ageing Research Reviews
- Publisher
- Elsevier BV
- Published
- 2016-03
- Volume
- 26
- Pages
- 22-36
- ISSN
- 1568-1637 (ISSN-L)
- OpenAlex
- W2193057007
- Cited by
- 157
- References
- 178
- Citations by year
- 2026: 8 · 2025: 21 · 2024: 17 · 2023: 21 · 2022: 22 · 2021: 18 · 2020: 12 · 2019: 10 · 2018: 14 · 2017: 8 · 2016: 6
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Ageing Research Reviews (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Keywords
- skeletal muscle regeneration, muscle aging, sarcopenia, muscle stem cells, immune cells, nutrition, amino acids, omega-3 fatty acids, polyphenols, vitamin D, muscle injury repair
- MeSH terms
- Immunosenescence, Aging, Humans, Nutritional Status, Regeneration, Muscle Fibers, Skeletal, Sarcopenia
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