Cited by 2,166Muscle Physiology and DisordersCongenital heart defects researchMuscle metabolism and nutrition

Satellite Cells and the Muscle Stem Cell Niche

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Yin, Hang, Price, Feodor, Rudnicki, Michael A.·2013·Physiological Reviews

Abstract

Adult skeletal muscle in mammals is a stable tissue under normal circumstances but has remarkable ability to repair after injury. Skeletal muscle regeneration is a highly orchestrated process involving the activation of various cellular and molecular responses. As skeletal muscle stem cells, satellite cells play an indispensible role in this process. The self-renewing proliferation of satellite cells not only maintains the stem cell population but also provides numerous myogenic cells, which proliferate, differentiate, fuse, and lead to new myofiber formation and reconstitution of a functional contractile apparatus. The complex behavior of satellite cells during skeletal muscle regeneration is tightly regulated through the dynamic interplay between intrinsic factors within satellite cells and extrinsic factors constituting the muscle stem cell niche/microenvironment. For the last half century, the advance of molecular biology, cell biology, and genetics has greatly improved our understanding of skeletal muscle biology. Here, we review some recent advances, with focuses on functions of satellite cells and their niche during the process of skeletal muscle regeneration.

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Crossref · 10.1152/physrev.00043.2011

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  • MuSC regenerative function is regulated by interactions with the extrinsic niche, including systemic proteins and local structural and soluble factors that influence cell cycle and transcription and alter muscle biomechanics and contractile forces.

    “The regenerative function of MuSCs is regulated by their interaction with components of their extrinsic tissue microenvironment or ‘niche,’ including systemic proteins and localized structural and soluble factors that affect cell cycle and transcriptional regulation18 and alter muscle biomechanical properties and contractile forces19,20.”
  • Self-renewal of SCs is maintained by the SC niche, including, but not limited to ECM components and myofibers.

    “Self-renewal of SCs is maintained by the SC niche, including, but not limited to ECM components and myofibers34,35.”

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Authors
Yin, H., Price, F., & Rudnicki, M. A.
Affiliations
Ottawa Hospital Research Institute (CA)
Venue
Physiological Reviews
Published
2013-01
Volume
93
Issue
1
Pages
23-67
ISSN
  • 0031-9333 (ISSN-L)
  • 1522-1210
OpenAlex
W2017075649
Cited by
2,166
References
600
Citations by year
2026: 139 · 2025: 165 · 2024: 198 · 2023: 210 · 2022: 216 · 2021: 211 · 2020: 196 · 2019: 168 · 2018: 177 · 2017: 131 · 2016: 115 · 2015: 106 · 2014: 95 · 2013: 36 · 2012: 1
FWCI
11.03
Type
journal article
Language
en
Open access
Locations
  • Physiological Reviews (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR044031)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Keywords
satellite cells, muscle stem cells, muscle stem cell niche, skeletal muscle regeneration, self-renewal, myogenesis, myofiber formation, muscle injury repair
MeSH terms
Animals, Cell Differentiation, Gene Expression Regulation, Humans, Muscular Diseases, Regeneration, Biomarkers, Muscle, Skeletal, Muscle Development, Satellite Cells, Skeletal Muscle, Cell Proliferation, Adult Stem Cells, Stem Cell Niche

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