Satellite Cells and the Muscle Stem Cell Niche
Open accessAbstract
Adult skeletal muscle in mammals is a stable tissue under normal circumstances but has remarkable ability to repair after injury. Skeletal muscle regeneration is a highly orchestrated process involving the activation of various cellular and molecular responses. As skeletal muscle stem cells, satellite cells play an indispensible role in this process. The self-renewing proliferation of satellite cells not only maintains the stem cell population but also provides numerous myogenic cells, which proliferate, differentiate, fuse, and lead to new myofiber formation and reconstitution of a functional contractile apparatus. The complex behavior of satellite cells during skeletal muscle regeneration is tightly regulated through the dynamic interplay between intrinsic factors within satellite cells and extrinsic factors constituting the muscle stem cell niche/microenvironment. For the last half century, the advance of molecular biology, cell biology, and genetics has greatly improved our understanding of skeletal muscle biology. Here, we review some recent advances, with focuses on functions of satellite cells and their niche during the process of skeletal muscle regeneration.
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MuSC regenerative function is regulated by interactions with the extrinsic niche, including systemic proteins and local structural and soluble factors that influence cell cycle and transcription and alter muscle biomechanics and contractile forces.
“The regenerative function of MuSCs is regulated by their interaction with components of their extrinsic tissue microenvironment or ‘niche,’ including systemic proteins and localized structural and soluble factors that affect cell cycle and transcriptional regulation18 and alter muscle biomechanical properties and contractile forces19,20.”
From The central role of muscle stem cells in regenerative failure with aging (2015) · cites this paper as [20]
Self-renewal of SCs is maintained by the SC niche, including, but not limited to ECM components and myofibers.
“Self-renewal of SCs is maintained by the SC niche, including, but not limited to ECM components and myofibers34,35.”
From In vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche (2021) · cites this paper as [35]
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“Pax7-expressing adult stem cells are normally quiescent, but when stimulated by damage or stress, they become activated and enter the cell cycle to either form new muscle fibers or self-renew and replenish the satellite cell pool, that will be used in the future [19-21].”
BackgroundSkeletal muscle tissue engineering: methods to form skeletal myotubes and their applications
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“A major hurdle towards assaying the functional potential of satellite cells was overcome by the identification of specific cell surface markers, allowing researchers to employ fluorescence-activated cell sorting (FACS) strategies for their prospective isolation [12].”
BackgroundSkeletal muscle regeneration and impact of aging and nutrition
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- Authors
- Yin, H., Price, F., & Rudnicki, M. A.
- Affiliations
- Ottawa Hospital Research Institute (CA)
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2013-01
- Volume
- 93
- Issue
- 1
- Pages
- 23-67
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- PMC
- PMC4073943
- OpenAlex
- W2017075649
- Cited by
- 2,166
- References
- 600
- Citations by year
- 2026: 139 · 2025: 165 · 2024: 198 · 2023: 210 · 2022: 216 · 2021: 211 · 2020: 196 · 2019: 168 · 2018: 177 · 2017: 131 · 2016: 115 · 2015: 106 · 2014: 95 · 2013: 36 · 2012: 1
- FWCI
- 11.03
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Physiological Reviews (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR044031)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- satellite cells, muscle stem cells, muscle stem cell niche, skeletal muscle regeneration, self-renewal, myogenesis, myofiber formation, muscle injury repair
- MeSH terms
- Animals, Cell Differentiation, Gene Expression Regulation, Humans, Muscular Diseases, Regeneration, Biomarkers, Muscle, Skeletal, Muscle Development, Satellite Cells, Skeletal Muscle, Cell Proliferation, Adult Stem Cells, Stem Cell Niche
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