The DOI matches its Crossref record; 79 of the 79 references it cites were found in a registry or an index.
Risk of cardiovascular disease morbidity and mortality in frail and pre-frail older adults: Results from a meta-analysis and exploratory meta-regression analysis
Open accessAbstract
Frailty is common and associated with poorer outcomes in the elderly, but its role as potential cardiovascular disease (CVD) risk factor requires clarification. We thus aimed to meta-analytically evaluate the evidence of frailty and pre-frailty as risk factors for CVD. Two reviewers selected all studies comparing data about CVD prevalence or incidence rates between frail/pre-frail vs. robust. The association between frailty status and CVD in cross-sectional studies was explored by calculating and pooling crude and adjusted odds ratios (ORs) ±95% confidence intervals (CIs); the data from longitudinal studies were pooled using the adjusted hazard ratios (HRs). Eighteen cohorts with a total of 31,343 participants were meta-analyzed. Using estimates from 10 cross-sectional cohorts, both frailty and pre-frailty were associated with higher odds of CVD than robust participants. Longitudinal data were obtained from 6 prospective cohort studies. After a median follow-up of 4.4 years, we identified an increased risk for faster onset of any-type CVD in the frail (HR=1.70 [95%CI, 1.18–2.45]; I2=66%) and pre-frail (HR=1.23 [95%CI, 1.07–1.36]; I2=67%) vs. robust groups. Similar results were apparent for time to CVD mortality in the frail and pre-frail groups. In conclusion, frailty and pre-frailty constitute addressable and independent risk factors for CVD in older adults.
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Frailty in Older Adults: Evidence for a Phenotype
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Frailty: implications for clinical practice and public health
Hoogendijk, E. O., Afilalo, J., Ensrud, K. E., Kowal, P., Onder, G., & Fried, L. P. (2019) · The Lancet · doi:10.1016/s0140-6736(19)31786-6 · Cited by 3,282
A multidimensional approach to frailty in older people
Pilotto, A., Custodero, C., Maggi, S., Polidori, M. C., Veronese, N., & Ferrucci, L. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101047 · Cited by 396
Self-citationVeronese, N., Stubbs, B., Volpato, S., Zuliani, G., Maggi, S., Cesari, M., Lipnicki, D. M., Smith, L., Schofield, P., Firth, J., et al. (2018) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2018.06.007 · Cited by 209
Self-citationShivappa, N., Stubbs, B., Hébert, J. R., Cesari, M., Schofield, P., Soysal, P., Maggi, S., & Veronese, N. (2018) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2017.08.006 · Cited by 104
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Metadata
- Authors
- Veronese, N., Cereda, E., Stubbs, B., Solmi, M., Luchini, C., Manzato, E., Sergi, G., Manu, P., Harris, T., Fontana, L., Strandberg, T., Amieva, H., Dumurgier, J., Elbaz, A., Tzourio, C., Eicholzer, M., Rohrmann, S., Moretti, C., D’Ascenzo, F., Quadri, G., Polidoro, A., Lourenço, R. A., Moreira, V. G., Sanchis, J., Scotti, V., Maggi, S., & Correll, C. U.
- Venue
- Ageing Research Reviews
- Publisher
- Elsevier BV
- Published
- 2017-05
- Volume
- 35
- Pages
- 63-73
- ISSN
- 1568-1637 (ISSN-L)
- OpenAlex
- W2582378536
- Cited by
- 305
- References
- 79
- FWCI
- 3.05
- Type
- journal article
- Language
- en
- Open access
- green
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- Veronese, N., Cereda, E., Stubbs, B., Solmi, M., Luchini, C., Manzato, E., Sergi, G., Manu, P., Harris, T., Fontana, L., Strandberg, T., Amieva, H., Dumurgier, J., Elbaz, A., Tzourio, C., Eicholzer, M., Rohrmann, S., Moretti, C., D’Ascenzo, F., . . . Correll, C. U. (2017). Risk of cardiovascular disease morbidity and mortality in frail and pre-frail older adults: Results from a meta-analysis and exploratory meta-regression analysis. Ageing Research Reviews. https://doi.org/10.1016/j.arr.2017.01.003
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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