The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Interleukin-6 serum levels and genotypes influence the risk for myocardial infarction
Abstract
Objective Several studies show that the inflammatory component in atherosclerosis may contribute to increased risk for cardiovascular disease (CVD). Interleukin-6 (IL-6) is a key pro-inflammatory and immune-stimulatory cytokine of presumed importance for CVD and the metabolic syndrome.Methods and results In this case-control study, 1179 surviving myocardial infarction (MI) cases and 1528 healthy controls were genotyped for three IL-6 promoter SNPs, and serum concentrations of IL-6 and C-reactive protein (CRP) were measured. In men, MI risk assessed as odds ratios (OR) was higher with increasing IL-6 levels, with the highest compared to the lowest IL-6 quartiles giving an OR of 2.7 [95% CI 1.7-4.4]. The ORs were independent from the effects of elevated CRP which were associated with modest MI risks (OR = 1.6 [95% CI 1.0-2.5]). Also, synergistic interactions between high IL-6 levels and hypercholesterolaemia further increased MI risk estimates. The -174C allele was associated with lower serum-insulin levels among male controls but did not significantly influence MI risk or IL-6 levels.Conclusions Elevated IL-6 levels are important risk markers for MI in men, the risk being further enhanced through synergistic interaction with hypercholesterolaemia. The data provide no clear evidence that polymorphisms in the IL-6 promotor region play a significant role in the pathogenesis of MI, and it remains to be further evaluated whether or not the -174C allele is of relevance for insulin resistance.
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“Plasma concentrations of IL-6 [31] and TNF-α have been shown to predict the risk of myocardial infarction in several studies [32]”
From Exercise as a Mean to Control Low‐Grade Systemic Inflammation (2008) · cites this paper as [31]
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Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link?
Yudkin, J. S., Kumari, M., Humphries, S. E., & Mohamed-Ali, V. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00463-3 · Cited by 1,775
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Relation of C-Reactive Protein and Coronary Heart Disease in the MRFIT Nested Case-Control Study
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Cytokines and Cytokine Receptors in Advanced Heart Failure
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Interleukin-6 induces cellular insulin resistance in hepatocytes.
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“It is possible that the proposed insulin receptor inhibiting effects from IL-6 [23] could provide a possible mechanism behind the potential interaction between insulin and IL-6, which was indicated among both men and women.”
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Psychosocial factors and prognosis in coronary heart disease
László, K. D. (2009) · Figshare · Cited by 1
Navarro, M. D. P. M., Acevedo, Y., Hernández Castillo, A., López, M., Ruiz, M. N., Bofelli, C., Rodríguez, G., Lizardo, M., Vicci, H., & Camacho, M. (2014) · Redalyc (Universidad Autónoma del Estado de México)
Genetic analyses of type 2 diabetes related metabolic risk factors : a twin study
Souren, N. Y. (2009) · Research Publications (Maastricht University) · doi:10.26481/dis.20090123ns
Reply to “Is interleukin-6 circulating levels associated with coronary artery disease?”
Niu, W. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.03.121
AlHomidani, H. H. (2015) · Surrey Research Insight Open Access (The University of Surrey)
From THE INSTITUTE OF ENVIRONMENTAL MEDICINE
Giuseppe, D. D. (2014)
ReviewArticle Exercise as a Mean to Control Low-Grade Systemic Inflammation
Mathur, N., & Pedersen, B. K. (2008)
Polimorfismo de genes de citocinas: ¿factores de riesgo cardiovascular en la población venezolana?
Fernández‐Mestre, M., Salazar-Alcalá, E., Matos-González, G., & Márquez, I. (2020) · Archivos de cardiología de México · doi:10.24875/acm.200003301
Polymorphism of cytokine genes: Cardiovascular risk factors in the Venezuelan population?
Fernández‐Mestre, M., Salazar-Alcalá, E., Matos-González, G., & Márquez, I. (2021) · Archivos de cardiolog�a de M�xico (English ed Internet) · doi:10.24875/acme.m21000220
Álvarez, B., & Docampo, M. M. (2005) · Elsevier eBooks · doi:10.1016/b978-012455900-4/50316-0
Caruso, M., Caruso, C., Candore, G., Rea, I. M., Vasto, S., Colonna‐Romano, G., & Lio, D. (2006) · CRC Press eBooks · doi:10.1201/9781420005325.ch25
Sapata, K. B. (2008) · Americanae (AECID Library)
Metadata
- Authors
- Bennet, A.
- Affiliations
- Karolinska Institutet (SE)
- Corresponding author
- Bennet, A
- ORCID
- Bennet, A
- Venue
- Atherosclerosis
- Publisher
- Elsevier BV
- Published
- 2003-12
- Volume
- 171
- Issue
- 2
- Pages
- 359-367
- ISSN
- 0021-9150 (ISSN-L)
- OpenAlex
- W1983297804
- Cited by
- 113
- References
- 30
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 5 · 2019: 5 · 2018: 2 · 2017: 4 · 2016: 3 · 2015: 3 · 2014: 5 · 2013: 9 · 2012: 10
- FWCI
- 2.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Atherosclerosis (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Hjärt-Lungfonden
- Vetenskapsrådet
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- interleukin-6, myocardial infarction, IL-6 promoter polymorphism, serum IL-6, C-reactive protein, hypercholesterolemia, genetic susceptibility, inflammation, insulin resistance, insulin, metabolic syndrome, cardiovascular risk
- MeSH terms
- C-Reactive Protein, Female, Genetic Markers, Genotype, Humans, Male, Myocardial Infarction, Reference Values, Sensitivity and Specificity, Severity of Illness Index, Cohort Studies, Interleukin-6, Incidence, Survival Rate, Case-Control Studies, Risk Assessment
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