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Interleukin-6 serum levels and genotypes influence the risk for myocardial infarction
Abstract
Objective Several studies show that the inflammatory component in atherosclerosis may contribute to increased risk for cardiovascular disease (CVD). Interleukin-6 (IL-6) is a key pro-inflammatory and immune-stimulatory cytokine of presumed importance for CVD and the metabolic syndrome.Methods and results In this case-control study, 1179 surviving myocardial infarction (MI) cases and 1528 healthy controls were genotyped for three IL-6 promoter SNPs, and serum concentrations of IL-6 and C-reactive protein (CRP) were measured. In men, MI risk assessed as odds ratios (OR) was higher with increasing IL-6 levels, with the highest compared to the lowest IL-6 quartiles giving an OR of 2.7 [95% CI 1.7-4.4]. The ORs were independent from the effects of elevated CRP which were associated with modest MI risks (OR = 1.6 [95% CI 1.0-2.5]). Also, synergistic interactions between high IL-6 levels and hypercholesterolaemia further increased MI risk estimates. The -174C allele was associated with lower serum-insulin levels among male controls but did not significantly influence MI risk or IL-6 levels.Conclusions Elevated IL-6 levels are important risk markers for MI in men, the risk being further enhanced through synergistic interaction with hypercholesterolaemia. The data provide no clear evidence that polymorphisms in the IL-6 promotor region play a significant role in the pathogenesis of MI, and it remains to be further evaluated whether or not the -174C allele is of relevance for insulin resistance.
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“Plasma concentrations of IL-6 [31] and TNF-α have been shown to predict the risk of myocardial infarction in several studies [32]”
From Exercise as a Mean to Control Low‐Grade Systemic Inflammation (2008) · cites this paper as [31]
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OLSSON, A. G., McMurray, J. J. V., Thorgeirsson, G., Spaulding, C. M., Slattery, J., Pyörälà, K., Færgeman, O., Wright, R. S., Berg, K. M., Wilhelmsen, L., et al. (1994) · The Lancet · Cited by 8,467
Ridker, P. M., Hennekens, C. H., Buring, J. E., & Rifai, N. (2000) · New England Journal of Medicine · doi:10.1056/nejm200003233421202 · Cited by 5,850
Ridker, P. M., Rifai, N., Stampfer, M. J., & Hennekens, C. H. (2000) · Circulation · doi:10.1161/01.cir.101.15.1767 · Cited by 2,429
Fishman, D., Faulds, G., Jeffery, R., Mohamed-Ali, V, Yudkin, J. S., Humphries, S., & Woo, P. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2629 · Cited by 2,243
Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link?
Yudkin, J. S., Kumari, M., Humphries, S. E., & Mohamed-Ali, V. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00463-3 · Cited by 1,775
Immune mechanisms in atherosclerosis.
Hansson, G. K., Jonasson, L., Seifert, P. S., & Stemme, S. (1989) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.9.5.567 · Cited by 1,172
Relation of C-Reactive Protein and Coronary Heart Disease in the MRFIT Nested Case-Control Study
Kuller, L. H., Tracy, R. P., Shaten, J., & Meilahn, E. N. (1996) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a008963 · Cited by 1,098
Cytokines and Cytokine Receptors in Advanced Heart Failure
Deswal, A. M., Petersen, N. J., Feldman, A. M., Young, J. B., White, B. G., & Mann, D. L. (2001) · Circulation · doi:10.1161/01.cir.103.16.2055 · Cited by 1,014
Frostegård, J., Ulfgren, A., Nyberg, P., Hedin, U., Swedenborg, J., Andersson, U., & Hansson, G. K. (1999) · Atherosclerosis · doi:10.1016/s0021-9150(99)00011-8 · Cited by 1,002
Interleukin-6 induces cellular insulin resistance in hepatocytes.
Senn, J. J., Klover, P. J., Nowak, I. A., & Mooney, R. A. (2002) · Diabetes · doi:10.2337/diabetes.51.12.3391 · Cited by 883 · cited 1×
“It is possible that the proposed insulin receptor inhibiting effects from IL-6 [23] could provide a possible mechanism behind the potential interaction between insulin and IL-6, which was indicated among both men and women.”
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Harmon, M. E., Lewis, J. L., Miller, C. P., Hoover, J. H., Ali, A.-M. S., Shuey, C., Cajero, M., Lucas, S., Zychowski, K. E., Pacheco, B., et al. (2017) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/jes.2016.79 · Cited by 65
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Huth, C., Illig, T., Herder, C., Gieger, C., Grallert, H., Vollmert, C., Rathmann, W., Hamid, Y. H., Pedersen, O. B., Hansen, T. F., et al. (2008) · Annals of Medicine · doi:10.1080/07853890802337037 · Cited by 59
Hou, H., Wang, C., Sun, F., Zhao, L., Dun, A., & Sun, Z. (2015) · Inflammation Research · doi:10.1007/s00011-015-0850-9 · Cited by 55
Niu, W., Liu, Y., Qi, Y., Wu, Z., Zhu, D., & Jin, W. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2011.12.098 · Cited by 54
László, K. D., Ahnve, S., Hallqvist, J., Ahlbom, A., & Janszky, I. (2009) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2009.02196.x · Cited by 51
Katzov, H., Bennet, A. M., Kehoe, P. G., Wiman, B., Gatz, M., Blennow, K., Lenhard, B., Pedersen, N. L., Fairé, U. D., & Prince, J. A. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh286 · Cited by 48
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Leander, K., Wiman, B., Hallqvist, J., Andersson, T., Ahlbom, A., & Fairé, U. D. (2007) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/hjr.0b013e328012e3cc · Cited by 45
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Riikola, A., Sipilä, K., Kähönen, M. A. P., Jula, A., Nieminen, M. S., Moilanen, L., Kesäniemi, Y. A., Lehtimäki, T. J., & Hulkkonen, J. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.06.004 · Cited by 45
Adiloğlu, A. K., Can, R., Nazlı, C., Öcal, A., Ergene, O., Tinaz, G. B., & Kişioğlu, N. (2005) · Europe PMC (PubMed Central) · Cited by 43
González‐Castro, T. B., Hernández‐Díaz, Y., Pérez‐Hernández, N., Tovilla‐Zárate, C. A., Juárez‐Rojop, I. E., López‐Narváez, M. L., Blachman-Braun, R., Posadas‐Sánchez, R., Vargas‐Alarcón, G., García-Flores, E., et al. (2019) · EXCLI journal · doi:10.17179/excli2019-1248 · Cited by 42
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Zheng, G., Chen, H., & Xiong, S.-Q. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034839 · Cited by 32
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Malaponte, G., Polesel, J., Candido, S., Sambataro, D., Bevelacqua, V., Anzaldi, M., Vella, N., Fiore, V., Militello, L., Mazzarino, M. C., et al. (2013) · Cytokine · doi:10.1016/j.cyto.2013.02.017 · Cited by 28
Yin, Y.-W., Hu, A., Sun, Q., Liu, H.-L., Wang, Q., Zeng, Y., Xu, R., Hou, Z., Zhang, Z.-D., Zhang, S.-J., et al. (2012) · Gene · doi:10.1016/j.gene.2012.04.075 · Cited by 28
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Giurgea, A., Margeta, C., Maca, T., Rezaie-Majd, A., Bucek, R. A., Manavi, M., Afarideh, R., Minar, E., & Baghestanian, M. (2006) · Journal of Cardiovascular Pharmacology · doi:10.1097/01.fjc.0000191970.65998.7a · Cited by 25
Ma, Y., Tang, R., Xu, Y., Peng, G., Liu, Y., Wang, X.-M., Wu, B., & Yu, J. (2011) · Human Immunology · doi:10.1016/j.humimm.2011.03.019 · Cited by 24
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YE, W., CHEN, S., JIN, S., & LU, J. (2013) · Molecular Medicine Reports · doi:10.3892/mmr.2013.1616 · Cited by 12
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Katzov, H., Bennet, A. M., Höglund, K., Wiman, B., Lütjohann, D., Brookes, A. J., Andreasen, N., Blennow, K., Fairé, U. D., & Prince, J. A. (2005) · Journal of Human Genetics · doi:10.1007/s10038-005-0341-x · Cited by 11
Self-citationShinohara, T. (2012) · Journal of Clinical & Experimental Cardiology · doi:10.4172/2155-9880.1000209 · Cited by 10
Gonzales, T. K., Yonker, J. A., Chang, V., Roan, C., Herd, P., & Atwood, C. (2017) · BMJ Open · doi:10.1136/bmjopen-2016-011529 · Cited by 11
Meng, Q., Sun, Z., Gu, H., Luo, J., Wang, J., Wang, C., & Su, H. (2019) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-019-0185-6 · Cited by 9
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Vasunilashorn, S. M., Glei, D. A., Lan, C.-Y., Brookmeyer, R., Weinstein, M., & Goldman, N. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.07.100 · Cited by 9
Bayoumy, N. M. K., Al-Sharaidh, A. S., Babay, Z. A., & Abdulgader, A. (2013) · Saudi Medical Journal · doi:10.15537/1658-3175.5784 · Cited by 8
Bulut, E. C., Kutucu, D. E., Üstünova, S., Ağırbaşlı, M. A., Dedeakayoğulları, H., Tarhan, Ç., Kapucu, A., Yeğen, B. Ç., Tansel, C. D., & Gürel-Gürevin, E. (2024) · Experimental Physiology · doi:10.1113/ep092052 · Cited by 7
El-Mashad, N., Elemshaty, W., Arfat, M. S., Koura, B. A., & Metwally, S. S. (2009) · PubMed · Cited by 7
Rantala, A. K., Lajunen, T. K., Juvonen, R., Paldanius, M., Silvennoinen‐Kassinen, S., Peitso, A., Vainio, O., Leinonen, M., & Saikku, P. (2011) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2011.02542.x · Cited by 6
Fonseca, D. M., Bonato, V. L. D., Silva, C. L., & Sartori, A. (2007) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2006005000175 · Cited by 6
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Zhou, J., Feng, J., & Li, X. (2016) · Genetics and Molecular Research · doi:10.4238/gmr.15038358 · Cited by 5
Hong, M., Bennet, A. M., Fairé, U. D., & Prince, J. A. (2007) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201803 · Cited by 5
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Rosenlund, M. (2005) · Figshare · Cited by 5
Luo, Y., Li, S., Ding, Y., & Shi, S. (2025) · BMC Medical Genomics · doi:10.1186/s12920-025-02167-8 · Cited by 4
Vidal, S. (2013) · Advances in Pharmacoepidemiology & Drug Safety · doi:10.4172/2167-1052.1000141 · Cited by 4
Zhang, H., Liu, C., Zhao, B., & Zhou, X. (2018) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2018.0075 · Cited by 3
Bezuch, N. E., Bradburn, S., Sipilä, S., Pääsuke, M., Gapeyeva, H., Maier, A. B., Hogrel, J., Barnouin, Y., Butler-Browne, G. S., Narici, M. V., et al. (2018) · Meta Gene · doi:10.1016/j.mgene.2018.10.007 · Cited by 3
Gonçalves, B. P., Flauzino, T., Inoue, C. J., de Paula, J. C. C., Galvão, T. C., de Alcantara, C. C., Miyazaki, P. K., Rosa, L., Westmore, S., Lozovoy, M. A. B., et al. (2020) · International Journal of Colorectal Disease · doi:10.1007/s00384-020-03743-3 · Cited by 3
Serum and genetic markers related to rapid clinical progression of coronary artery disease
Camarero, T. G., Remuzgo‐Martínez, S., Genre, F., López‐Mejías, R., Pulito‐Cueto, V., Fernández, G. V., Hwang, D.-H. L., Laso, F. S., Ongay, A. G., González-Gay, M. Á., et al. (2023) · Revista Española de Cardiología (English Edition) · doi:10.1016/j.rec.2023.04.005 · Cited by 3
Camarero, T. G., Remuzgo‐Martínez, S., Genre, F., López‐Mejías, R., Pulito‐Cueto, V., Veiga, G., Hwang, D.-H. L., Laso, F. S., Ongay, A. G., González-Gay, M. Á., et al. (2023) · Revista Española de Cardiología · doi:10.1016/j.recesp.2023.04.009 · Cited by 3
Cytokines and Late Preconditioning
Buxton, D. B. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.07.019 · Cited by 3
Gene polymorphism among hypertensive patients with coronary artery disease
Selvakumar, D. (2022) · Bioinformation · doi:10.6026/97320630018239 · Cited by 2
Genetic Factors Underlying Susceptibility to Acute Pyelonephritis and Post-infectious Renal Damage
Živković, M., Stojković, L., Spasojević, B., Kostic, M., & Stanković, A. (2013) · InTech eBooks · doi:10.5772/52852 · Cited by 2
Interleukin-6 gene promoter –174G/C polymorphism and insulin resistance: a pilot study
Tretjakovs, P., Latkovskis, G., Licis, N., Juhnēviča, D., Jurka, A., Bormane, I., Aivars, J. I., Stifts, A., & Pīrāgs, V. (2007) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2007.260 · Cited by 2
Interleukin-6 gene −572 G > C polymorphism and myocardial infarction risk
Ding, H.-G., Yin, Y.-W., & Liu, S.-L. (2020) · Open Medicine · doi:10.1515/med-2020-0407 · Cited by 1
Keshmiri, A., Derakhshan, A. R., Fazlinejad, A., & Faridhosseini, R. (2019) · Nepalese Heart Journal · doi:10.3126/njh.v16i1.23896 · Cited by 1
The Relationship between Mitral Chordae Rupture and Inflammation Level and Oxidative Stress
Kaplan, M., Yavuz, F., Davutoğlu, V., Yüce, M., Dönmez, Y., & Abacıoğlu, Ö. Ö. (2019) · European Journal of Therapeutics · doi:10.5152/eurjther.2019.19063 · Cited by 1
Is interleukin-6 circulating levels associated with coronary artery disease?
Liu, C. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.03.015 · Cited by 1
Metadata
- Authors
- Bennet, A.
- Affiliations
- Karolinska Institutet (SE)
- Corresponding author
- Bennet, A
- ORCID
- Bennet, A
- Venue
- Atherosclerosis
- Publisher
- Elsevier BV
- Published
- 2003-12
- Volume
- 171
- Issue
- 2
- Pages
- 359-367
- ISSN
- 0021-9150 (ISSN-L)
- OpenAlex
- W1983297804
- Cited by
- 113
- References
- 30
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 5 · 2019: 5 · 2018: 2 · 2017: 4 · 2016: 3 · 2015: 3 · 2014: 5 · 2013: 9 · 2012: 10
- FWCI
- 2.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Atherosclerosis (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Hjärt-Lungfonden
- Vetenskapsrådet
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- interleukin-6, myocardial infarction, IL-6 promoter polymorphism, serum IL-6, C-reactive protein, hypercholesterolemia, genetic susceptibility, inflammation, insulin resistance, insulin, metabolic syndrome, cardiovascular risk
- MeSH terms
- C-Reactive Protein, Female, Genetic Markers, Genotype, Humans, Male, Myocardial Infarction, Reference Values, Sensitivity and Specificity, Severity of Illness Index, Cohort Studies, Interleukin-6, Incidence, Survival Rate, Case-Control Studies, Risk Assessment
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