Cited by 109Cardiovascular and exercise physiologyLipoproteins and Cardiovascular HealthPhysical Activity and Health

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Aerobic exercise and HDL2-C: A meta-analysis of randomized controlled trials

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Kelley, George A., Kelley, K.S.·2006·Atherosclerosis

DOI 10.1016/j.atherosclerosis.2005.04.005PMC PMC2447856

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Abstract

Purpose Use the meta-analytic approach to examine the effects of aerobic exercise on high-density lipoprotein two cholesterol (HDL2-C) in adults. STUDY SOURCES: (1) Computerized literature searches; (2) cross-referencing from retrieved articles; (3) hand-searching; and (4) expert review of our reference list.Study selection (1) Randomized controlled trials; (2) aerobic exercise > or = 8 weeks; (3) adults > or = 18 years of age; (4) studies published in journal, dissertation, or master's thesis format; (5) studies published in the English-language between January 1, 1955 and January 1, 2003; and (6) assessment of HDL2-C in the fasting state.Data abstraction All coding conducted by both authors, independent of each other. Discrepancies were resolved by consensus.Results Nineteen randomized controlled trials representing 20 HDL2-C outcomes from 984 males and females (516 exercise, 468 control) were pooled for analysis. Using random-effects modeling and bootstrap confidence intervals (BCI), a statistically significant increase of approximately 11% was observed for HDL2-C (X +/- S.E.M., 2.6 +/- 0.9 mg/dl, 95% BCI, 1.0-4.4 mg/dl). With each study deleted from the model once, results remained statistically significant. Increases in HDL2-C were independent of decreases in body weight, body mass index (kg/m2), and percent body fat.Conclusion Aerobic exercise increases HDL2-C in adults.

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Authors: Kelley, G. A., & Kelley, K. S.
Affiliations: West Virginia University (US)
Corresponding author: Kelley, George A.
ORCID: Kelley, George A.
Kelley, K.S.
Venue: Atherosclerosis
Publisher: Elsevier BV
Published: 2006-01
Volume: 184
Issue: 1
Pages: 207-215
ISSN: 0021-9150 (ISSN-L)
DOI: 10.1016/j.atherosclerosis.2005.04.005
PMC: PMC2447856
OpenAlex: W2046249078
Cited by: 109
References: 45
Citations by year: 2026: 2 · 2025: 1 · 2024: 7 · 2023: 2 · 2022: 3 · 2021: 6 · 2020: 5 · 2019: 4 · 2018: 5 · 2017: 5 · 2016: 1 · 2015: 9 · 2014: 6 · 2013: 14 · 2012: 4
FWCI: 1.09
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Atherosclerosis (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Heart, Lung, and Blood Institute (R01HL069802)
Topics: Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
Keywords: aerobic exercise, HDL2, high-density lipoprotein, HDL subfractions, lipid metabolism, body weight, body mass index, fat mass, cardiovascular risk factors
MeSH terms: Adult, Coronary Disease, Female, Humans, Lipoproteins, HDL, Male, Risk Factors, Biomarkers, Exercise, Randomized Controlled Trials as Topic, Lipoproteins, HDL2

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Aerobic exercise and HDL2-C: A meta-analysis of randomized controlled trials

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