Cited by 66Lipoproteins and Cardiovascular HealthCholesterol and Lipid MetabolismLipid metabolism and disorders

Effects of fenofibrate and simvastatin on HDL-related biomarkers in low-HDL patients

Franceschini, Guido, Calabresi, Laura, Colombo, Cinzia, Favari, Elda, Bernini, Franco, Sirtori, Cesare R.·2007·Atherosclerosis

Abstract

The objective of the present study was to compare the effects of fenofibrate versus simvastatin on various HDL-related biomarkers in dyslipidemic patients with low HDL-C, in whom it is as yet unclear whether a statin or a fibrate is the most appropriate treatment. Fifty-two patients received either fenofibrate (160 mg/day) or simvastatin (40 mg/day) for 8 weeks in a randomized, double-blind, parallel group trial. Simvastatin effectively lowered plasma LDL-C and apoB levels, but did not change plasma HDL levels and HDL-related biomarkers, except for a small, significant increase in the capacity of plasma to promote SR-BI mediated cholesterol efflux. Fenofibrate did not affect plasma LDL-C levels but lowered triglycerides, and exerted a remarkable HDL-C raising activity (+22%), with patients in the lowest range of HDL-C getting the maximal benefit. The HDL-C raise was associated with a shift of HDL from large to small particles, and from LpA-I to LpA-I:A-II, which might explain the observed increase in the plasma capacity to promote ABCA1 mediated efflux with no changes in SR-BI efflux. The distinct and complementary effects of fenofibrate and simvastatin on lipid parameters and HDL-related biomarkers suggest that a combination therapy with the two drugs in dyslipidemic patients with low HDL would be fully justified.

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Crossref · 10.1016/j.atherosclerosis.2006.10.017

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  • Fenofibrate treatment typically reduces serum triglycerides by a mean change of −93.7 mg/dL (−39.3%), increases high density lipoprotein cholesterol by +5.5 mg/dL (+12.4%), and reduces low density lipoprotein cholesterol by −17.9 mg/dL (−12.3%).

    “Typical changes in serum lipids as a result of FF treatment include clinically important mean reductions of serum triglycerides (TG) by a mean change of −93.7 mg/dL (−39.3%), increases of high density lipoprotein cholesterol (HDLC) by +5.5 mg/dL (+12.4%), and reductions in low density lipoprotein cholesterol (LDLC) by −17.9 mg/dL (−12.3%).”

    From Fenofibrate and metabolic syndrome (2010) · cites this paper as [34]

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Authors
Franceschini, G., Calabresi, L., Colombo, C., Favari, E., Bernini, F., & Sirtori, C. R.
Affiliations
  • University of Milan (IT)
  • University of Parma (IT)
Corresponding author
Franceschini, Guido
Venue
Atherosclerosis
Publisher
Elsevier BV
Published
2007-12
Volume
195
Issue
2
Pages
385-391
ISSN
0021-9150 (ISSN-L)
OpenAlex
W2135426425
Cited by
66
References
40
Citations by year
2024: 2 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 6 · 2017: 1 · 2016: 7 · 2015: 3 · 2014: 5 · 2013: 8 · 2012: 4
FWCI
3.05
Type
journal article
Language
en
Open access
closed
Locations
  • Atherosclerosis (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords
fenofibrate, simvastatin, low HDL cholesterol, dyslipidemia, LDL cholesterol, apolipoprotein B, HDL particle size, apolipoprotein A-I, triglycerides, statins, fibrates, combination therapy
MeSH terms
Aged, Hypolipidemic Agents, Apolipoproteins, Double-Blind Method, Female, Humans, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Fenofibrate, ATP-Binding Cassette Transporters, Simvastatin, Scavenger Receptors, Class B, ATP Binding Cassette Transporter 1

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