The DOI matches its Crossref record; 37 of the 38 references it cites were found in a registry or an index.
Ethnic differences in the ability of triglyceride levels to identify insulin resistance
Abstract
The Metabolic Syndrome is used to predict the onset of coronary artery disease and Type 2 diabetes. As the predictive value of the Metabolic Syndrome has been challenged, alternative syndromes have been developed. All of these syndromes were developed in populations that were predominantly non-Hispanic white (NHW). They include the Enlarged Waist Elevated Triglyceride Syndrome, the Overweight-Lipid Syndrome and the Hypertriglyceridemic Waist Syndrome. The first applies to postmenopausal women, the second to overweight individuals (BMI> or =25 kg/m(2)), and the third to men. Each syndrome uses hypertriglyceridemia as a criterion. However, the definition of hypertriglyceridemia varies by syndrome i.e. TG> or =128 mg/dL for the Enlarged Waist Elevated Triglyceride Syndrome, TG> or =130 mg/dL for the Overweight-Lipid Syndrome, > or =150 mg/dL for the Metabolic Syndrome, and TG> or =176 mg/dL for the Hypertriglyceridemic Waist Syndrome. Insulin resistance and hypertriglyceridemia are highly correlated. But as insulin resistant non-Hispanic blacks (NHB) often have triglyceride (TG) levels below the thresholds set by these syndromes, the ability of either TG or these syndromes to identify high risk NHB is unknown. Using the National Health and Nutrition Examination Survey (NHANES) 1999-2002, our goals were to determine by ethnicity: (1) the prevalence of each of these syndromes; (2) the ability of fasting TG concentrations to identify insulin resistance at cut-off levels established…
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“Moreover, there are both ethnic differences in cut-offs and gender variations [3,13].”
From Optimal Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) Cut-Offs: A Cross-Sectional Study in the Czech Population (2019) · cites this paper as [13]
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Miller, M., Stone, N. J., Ballantyne, C., Bittner, V., Criqui, M. H., Ginsberg, H. N., Goldberg, A. C., Howard, W. J., Jacobson, M. S., Kris-Etherton, P. M., et al. (2011) · Circulation · doi:10.1161/cir.0b013e3182160726 · Cited by 1,871
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Trends in insulin resistance: insights into mechanisms and therapeutic strategy
Li, M., Chi, X., Wang, Y., Setrerrahmane, S., Xie, W., & Xu, H. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01073-0 · Cited by 939
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Tahapary, D. L., Pratisthita, L. B., Fitri, N. A., Marcella, C., Wafa, S., Kurniawan, F., Rizka, A., Tarigan, T. J. E., Harbuwono, D. S., Purnamasari, D., et al. (2022) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2022.102581 · Cited by 661
Metadata
- Authors
- Sumner, A. E., & Cowie, C. C.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Sumner, Anne E.
- Venue
- Atherosclerosis
- Publisher
- Elsevier BV
- Published
- 2008-02
- Volume
- 196
- Issue
- 2
- Pages
- 696-703
- ISSN
- 0021-9150 (ISSN-L)
- OpenAlex
- W2079519649
- Cited by
- 273
- References
- 38
- Citations by year
- 2026: 6 · 2025: 14 · 2024: 22 · 2023: 7 · 2022: 16 · 2021: 13 · 2020: 13 · 2019: 16 · 2018: 17 · 2017: 11 · 2016: 20 · 2015: 18 · 2014: 10 · 2013: 18 · 2012: 13
- FWCI
- 9.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Atherosclerosis (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Minnesota
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (N01-DK-1-2478)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- insulin resistance, hypertriglyceridemia, ethnic differences, metabolic syndrome, Mexican Americans, non-Hispanic blacks, non-Hispanic whites, HOMA
- MeSH terms
- Adult, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Female, Health Surveys, Humans, Insulin Resistance, Male, Middle Aged, Nutrition Surveys, Regression Analysis, Risk, Triglycerides, Hypertriglyceridemia, Cohort Studies, Mexican Americans, Metabolic Syndrome, Black People, White People, Waist-Hip Ratio, Overweight
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