Sedentary time and cardio-metabolic biomarkers in US adults: NHANES 2003–06
Open accessAbstract
AIMS: Prolonged sedentary time is ubiquitous in developed economies and is associated with an adverse cardio-metabolic risk profile and premature mortality. This study examined the associations of objectively assessed sedentary time and breaks (interruptions) in sedentary time with continuous cardio-metabolic and inflammatory risk biomarkers, and whether these associations varied by sex, age, and/or race/ethnicity. METHODS AND RESULTS: Cross-sectional analyses with 4757 participants (≥ 20 years) from the 2003/04 and 2005/06 US National Health and Nutrition Examination Survey (NHANES). An Actigraph accelerometer was used to derive sedentary time [< 100 counts per minute (cpm)] and breaks in sedentary time. Independent of potential confounders, including moderate-to-vigorous exercise, detrimental linear associations (P for trends < 0.05) of sedentary time with waist circumference, HDL-cholesterol, C-reactive protein, triglycerides, insulin, HOMA-%B, and HOMA-%S were observed. Independent of potential confounders and sedentary time, breaks were beneficially associated with waist circumference and C-reactive protein (P for trends <0.05). There was limited evidence of meaningful differences in associations with biomarkers by age, sex, or race/ethnicity. Notable exceptions were sex-differences in the associations of sedentary time and breaks with HDL-cholesterol, and race/ethnicity differences in the association of sedentary time with waist circumference with associations detrimental in non-Hispanic whites, null in Mexican Americans, and beneficial in non-Hispanic blacks. CONCLUSION: These are the first population-representative findings on the deleterious associations of prolonged sedentary time with cardio-metabolic and inflammatory biomarkers. The findings suggest that clinical communications and preventive health messages on reducing and breaking up sedentary time may be beneficial for cardiovascular disease risk.
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The influence of SB might be independent of time spent in MVPA.
“There is some evidence that the influence of SB might be independent of time spent in MVPA [6]”
The models' fit to the data was in line with previous reports, with moderate amount of variance explained for systolic blood pressure (R2 adj = 0.21), HDL (R2 adj = 0.22), CRP (R2 adj = 0.26), plasma glucose (R2 adj = 0.33), insulin (R2 adj = 0.40) and HOMA (R2 adj = 0.42).
“The models’ fit to the data was in line with previous reports [1,6,10,14–17], with moderate amount of variance explained for systolic blood pressure (R2 adj = 0.21), HDL (R2 adj = 0.22), CRP (R2 adj = 0.26), plasma glucose (R2 adj = 0.33), insulin (R2 adj = 0.40) and HOMA (R2 adj = 0.42).”
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Cites
‘Small Changes' to Diet and Physical Activity Behaviors for Weight Management
Hills, A. P., Byrne, N. M., Lindstrom, R. C., & Hill, J. O. (2013) · Obesity Facts · doi:10.1159/000345030 · Cited by 9,526 · see citing works
Physical Activity in the United States Measured by Accelerometer
TROIANO, R. P., BERRIGAN, D., DODD, K. W., MÂSSE, L. C., TILERT, T., & MCDOWELL, M. (2008) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31815a51b3 · Cited by 7,638 · see citing works
Calibration of the Computer Science and Applications, Inc. accelerometer
FREEDSON, P. S., MELANSON, E., & SIRARD, J. (1998) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199805000-00021 · Cited by 3,825 · see citing works
Heart Disease and Stroke Statistics—2008 Update
Writing Group Members, Rosamond, W. D., Flegal, K. M., Furie, K. L., Go, A. S., Greenlund, K. J., Haase, N., Hailpern, S. M., Ho, M., Howard, V. J., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.187998 · Cited by 3,745 · see citing works
National Center for Health Statistics (NCHS)
Feinleib, M. (2005) · Encyclopedia of Biostatistics · doi:10.1002/0470011815.b2a16042 · Cited by 3,134 · see citing works
Total energy intake: implications for epidemiologic analyses.
WILLETT, W., & STAMPFER, M. J. (1986) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114366 · Cited by 2,751 · see citing works
RE: “TOTAL ENERGY INTAKE: IMPLICATIONS FOR EPIDEMIOLOGIC ANALYSES”
Palmgren, J., & Kushi, L. H. (1991) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a115841 · Cited by 2,712 · see citing works
Amount of Time Spent in Sedentary Behaviors in the United States, 2003-2004
Matthews, C. E., Chen, K. Y., Freedson, P. S., Buchowski, M. S., Beech, B. M., Pate, R. R., & Troiano, R. P. (2008) · American Journal of Epidemiology · doi:10.1093/aje/kwm390 · Cited by 2,631 · see citing works
Self-citationToo Much Sitting: The Population Health Science of Sedentary Behavior
Owen, N., Healy, G. N., Matthews, C. E., & Dunstan, D. W. (2010) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e3181e373a2 · Cited by 2,202 · see citing works
Self-citationHamilton, M. T., Hamilton, D. G., & Zderic, T. W. (2007) · Diabetes · doi:10.2337/db07-0882 · Cited by 1,655 · see citing works
Sitting time and mortality from all causes, cardiovascular disease, and cancer
KATZMARZYK, P. T., CHURCH, T. S., CRAIG, C. L., & BOUCHARD, C. (2009) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181930355 · Cited by 1,611 · see citing works
Healy, G. N., Dunstan, D. W., Salmon, J., Cerin, E., Shaw, J. E., Zimmet, P. Z., & Owen, N. (2008) · Diabetes Care · doi:10.2337/dc07-2046 · Cited by 1,465 · see citing works
Self-citationEuropean cardiovascular disease statistics
Allender, S. E., Scarborough, P., Peto, V., Rayner, M., Leal, J., Luengo-Fernández, R., & Gray, A. M. (2008) · Deakin Research Online (Deakin University) · Cited by 1,459 · see citing works
Objectively Measured Sedentary Time, Physical Activity, and Metabolic Risk
Healy, G. N., Wijndaele, K., Dunstan, D. W., Shaw, J. E., Salmon, J., Zimmet, P. Z., & Owen, N. (2008) · Diabetes Care · doi:10.2337/dc07-1795 · Cited by 1,100 · see citing works
Self-citationDunstan, D. W., Barr, E. L. M., Healy, G. N., Salmon, J., Shaw, J. E., Balkau, B., Magliano, D. J., Cameron, A. J., Zimmet, P. Z., & Owen, N. (2010) · Circulation · doi:10.1161/circulationaha.109.894824 · Cited by 825 · see citing works
Self-citationHealy, G. N., Dunstan, D. W., Salmon, J., Cerin, E., Shaw, J. E., Zimmet, P. Z., & Owen, N. (2007) · Diabetes Care · doi:10.2337/dc07-0114 · Cited by 627 · see citing works
Self-citationVisceral Fat, Waist Circumference, and BMI: Impact of Race/ethnicity
Carroll, J. F., Chiapa, A. L., Rodriquez, M., Phelps, D. R., Cardarelli, K., Vishwanatha, J. K., Bae, S., & Cardarelli, R. (2008) · Obesity · doi:10.1038/oby.2007.92 · Cited by 362 · see citing works
Ethnic differences in the ability of triglyceride levels to identify insulin resistance
Sumner, A. E., & Cowie, C. C. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.12.018 · Cited by 273 · see citing works
Insulin resistance and associated compensatory responses in african-american and Hispanic children.
Goran, M., Bergman, R., Cruz, M., & Watanabe, R. (2002) · Diabetes Care · doi:10.2337/diacare.25.12.2184 · Cited by 263 · see citing works
Physical Activity and Insulin Sensitivity
Balkau, B., Mhamdi, L., Oppert, J., Nolan, J. J., Golay, A., Porcellati, F., Laakso, M., Ferrannini, E., & on behalf of the EGIR-RISC Study Group (2008) · Diabetes · doi:10.2337/db07-1605 · Cited by 260 · see citing works
Emberson, J. (2004) · European Heart Journal · doi:10.1016/j.ehj.2003.11.012 · Cited by 236 · see citing works
Physical Activity and Metabolic Risk in Individuals With a Family History of Type 2 Diabetes
Ekelund, U., Griffin, S. J., & Wareham, N. J. (2007) · Diabetes Care · doi:10.2337/dc06-1883 · Cited by 163 · see citing works
The DECODE Insulin Study Group (2004) · Diabetologia · doi:10.1007/s00125-004-1433-4 · Cited by 159 · see citing works
Kruszon‐Moran, D., & McQuillan, G. M. (2005) · PsycEXTRA Dataset · doi:10.1037/e609182007-001 · Cited by 71 · see citing works
Bergeron, J., Couillard, C., Després, J., Gagnon, J., Leon, A. S., Rao, D. C., Skinner, J. S., Wilmore, J. H., & Bouchard, C. (2001) · Atherosclerosis · doi:10.1016/s0021-9150(01)00515-9 · Cited by 44 · see citing works
Television Viewing Is Not Predictive of BMI in Black and Hispanic Young Adult Females
Richmond, T. K., Walls, C. E., Gooding, H. C., & Field, A. E. (2009) · Obesity · doi:10.1038/oby.2009.391 · Cited by 15 · see citing works
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- Dunstan DW, Barr ELM, Healy GN, Salmon J, Shaw JE, Balkau B, Magliano DJ, Cameron AJ, Zimmet PZ, Owen N. Television viewing time and mortality: the AusDiab study. Circulation 2010;121:384 -391.
Cited by
Sorted by citations
Wilmot, E. G., Edwardson, C. L., Achana, F. A., Davies, M. J., Gorely, T., Gray, L. J., Khunti, K., Yates, T., & Biddle, S. J. H. (2012) · Diabetologia · doi:10.1007/s00125-012-2677-z · Cited by 1,789 · see citing works
Breaking Up Prolonged Sitting Reduces Postprandial Glucose and Insulin Responses
Dunstan, D. W., Kingwell, B. A., Larsen, R., Healy, G. N., Cerin, E., Hamilton, M. T., Shaw, J. E., Bertovic, D. A., Zimmet, P. Z., Salmon, J., et al. (2012) · Diabetes Care · doi:10.2337/dc11-1931 · Cited by 1,203 · see citing works
Self-citationEkelund, U. (2012) · JAMA · doi:10.1001/jama.2012.156 · Cited by 1,158 · see citing works
Chastin, S. F. M., Palarea-Albaladejo, J., Dontje, M. L., & Skelton, D. A. (2015) · PLOS ONE · doi:10.1371/journal.pone.0139984 · Cited by 1,034 · see citing works
“There is some evidence that the influence of SBmight be independent of time spent in MVPA [6] but this is ignoring the possible confounding effects of sleep and LIPA.”
Sitting time and all-cause mortality risk in 222,497 Australian adults
van der Ploeg, H. P. (2012) · Archives of Internal Medicine · doi:10.1001/archinternmed.2011.2174 · Cited by 884 · see citing works
Young, D. R., Hivert, M.-F., Alhassan, S., Camhi, S. M., Ferguson, J. F., Katzmarzyk, P. T., Lewis, C. E., Owen, N., Perry, C. K., Siddique, J., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000440 · Cited by 791 · see citing works
Self-citationAmount of time spent in sedentary behaviors and cause-specific mortality in US adults
Matthews, C. E., George, S. M., Moore, S. C., Bowles, H. R., Blair, A., Park, Y., Troiano, R. P., Hollenbeck, A., & Schatzkin, A. (2012) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.019620 · Cited by 655 · see citing works
Self-citationMeasurement of Adults' Sedentary Time in Population-Based Studies
Healy, G. N., Clark, B. K., Winkler, E. A. H., Gardiner, P. A., Brown, W. J., & Matthews, C. E. (2011) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2011.05.005 · Cited by 628 · see citing works
Self-citationToo much sitting – A health hazard
Dunstan, D. W., Howard, B., Healy, G. N., & Owen, N. G. (2012) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2012.05.020 · Cited by 583 · see citing works
Self-citationPatterns of Sedentary Behavior and Mortality in U.S. Middle-Aged and Older Adults
Diaz, K. M., Howard, V. J., Hutto, B., Colabianchi, N., Vena, J. E., Safford, M. M., Blair, S. N., & Hooker, S. P. (2017) · Annals of Internal Medicine · doi:10.7326/m17-0212 · Cited by 533 · see citing works
Sedentary behaviour and cardiovascular disease: a review of prospective studies
Ford, E. S., & Caspersen, C. J. (2012) · International Journal of Epidemiology · doi:10.1093/ije/dys078 · Cited by 530 · see citing works
The contribution of office work to sedentary behaviour associated risk
Parry, S. P., & Straker, L. M. (2013) · BMC Public Health · doi:10.1186/1471-2458-13-296 · Cited by 512 · see citing works
Considerations when using the activPAL monitor in field-based research with adult populations
Edwardson, C. L., Winkler, E. A. H., Bodicoat, D. H., Yates, T., Davies, M. J., Dunstan, D. W., & Healy, G. N. (2017) · Journal of Sport and Health Science · doi:10.1016/j.jshs.2016.02.002 · Cited by 502 · see citing works
Self-citationSedentary behaviour and the risk of depression: a meta-analysis
Zhai, L., Zhang, Y., & Zhang, D. (2015) · British Journal of Sports Medicine · doi:10.1136/bjsports-2014-093613 · Cited by 500 · see citing works
Thorp, A. A., Healy, G. N., WINKLER, E. A. H., Clark, B., Gardiner, P. A., Owen, N. G., & Dunstan, D. W. (2012) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/1479-5868-9-128 · Cited by 471 · see citing works
Self-citationBuckley, J., Hedge, A., Yates, T. E., Copeland, R. J., Loosemore, M. P., Hamer, M., Bradley, G., & Dunstan, D. W. (2015) · British Journal of Sports Medicine · doi:10.1136/bjsports-2015-094618 · Cited by 439 · see citing works
Self-citationPeddie, M. C., Bone, J. L., Rehrer, N. J., Skeaff, C. M., Gray, A. R., & Perry, T. L. (2013) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.051763 · Cited by 431 · see citing works
Buman, M. P., Winkler, E. A. H., Kurka, J. M., Hekler, E. B., Baldwin, C. M., Owen, N., Ainsworth, B. E., Healy, G. N., & Gardiner, P. A. (2014) · American Journal of Epidemiology · doi:10.1093/aje/kwt292 · Cited by 427 · see citing works
Self-citationDempsey, P. C., Larsen, R. N., Sethi, P., Sacre, J. W., Straznicky, N. E., Cohen, N. D., Cerin, E., Lambert, G. W., Owen, N., Kingwell, B. A., et al. (2016) · Diabetes Care · doi:10.2337/dc15-2336 · Cited by 405 · see citing works
Self-citationLobelo, F., Rohm Young, D., Sallis, R., Garber, M. D., Billinger, S. A., Duperly, J., Hutber, A., Pate, R. R., Thomas, R. J., Widlansky, M. E., et al. (2018) · Circulation · doi:10.1161/cir.0000000000000559 · Cited by 402 · see citing works
Relationship of Sedentary Behavior and Physical Activity to Incident Cardiovascular Disease
Chomistek, A. K., Manson, J. E., Stefanick, M. L., Lu, B., Sands-Lincoln, M., Going, S. B., Garcia, L., Allison, M. A., Sims, S. T., LaMonte, M. J., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.03.031 · Cited by 389 · see citing works
“In accelerometer studies, having a higher number of breaks in sedentary time was inversely associated with waist circumference, BMI, triglycerides, 2-h plasma glucose, and C-reactive protein, independent of total time spent sitting and physical activity (22,23).”
Alkhajah, T. A., Reeves, M. M., Eakin, E., WINKLER, E. A. H., Owen, N. G., & Healy, G. N. (2012) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2012.05.027 · Cited by 381 · see citing works
Self-citationPrince, S. A., Saunders, T. J., Gresty, K., & Reid, R. D. (2014) · Obesity Reviews · doi:10.1111/obr.12215 · Cited by 382 · see citing works
Physiology of sedentary behavior
Pinto, A. J., Bergouignan, A., Dempsey, P. C., Roschel, H., Owen, N. G., Gualano, B., & Dunstan, D. W. (2023) · Physiological Reviews · doi:10.1152/physrev.00022.2022 · Cited by 400 · see citing works
Self-citationMeta‐analysis of the relationship between breaks in sedentary behavior and cardiometabolic health
Chastin, S. F. M., Egerton, T., Leask, C., & Stamatakis, E. (2015) · Obesity · doi:10.1002/oby.21180 · Cited by 363 · see citing works
Television Viewing and Time Spent Sedentary in Relation to Cancer Risk: A Meta-Analysis
Schmid, D., & Leitzmann, M. F. (2014) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dju098 · Cited by 359 · see citing works
Reducing sitting time in office workers: Short-term efficacy of a multicomponent intervention
Healy, G. N., Eakin, E., LaMontagne, A. D., Owen, N. G., WINKLER, E. A. H., Wiesner, G., Gunning, L., Neuhaus, M., Lawler, S., Fjeldsoe, B. S., et al. (2013) · Preventive Medicine · doi:10.1016/j.ypmed.2013.04.004 · Cited by 340 · see citing works
Self-citationHenson, J., Yates, T., Biddle, S. J. H., Edwardson, C. L., Khunti, K., Wilmot, E. G., Gray, L. J., Gorely, T., Nimmo, M. A., & Davies, M. J. (2013) · Diabetologia · doi:10.1007/s00125-013-2845-9 · Cited by 337 · see citing works
Sit less and move more for cardiovascular health: emerging insights and opportunities
Dunstan, D. W., Dogra, S., Carter, S. E., & Owen, N. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00547-y · Cited by 333 · see citing works
Self-citationNeuhaus, M., Eakin, E., Straker, L. M., Owen, N. G., Dunstan, D. W., Reid, N., & Healy, G. N. (2014) · Obesity Reviews · doi:10.1111/obr.12201 · Cited by 329 · see citing works
Self-citationSedentary Behaviour as an Emerging Risk Factor for Cardiometabolic Diseases in Children and Youth
Saunders, T. J., Chaput, J., & Tremblay, M. S. (2014) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2013.08.266 · Cited by 331 · see citing works
Loh, R., Stamatakis, E., Folkerts, D., Allgrove, J. E., & Moir, H. J. (2020) · Sports Medicine · doi:10.1007/s40279-019-01183-w · Cited by 326 · see citing works
Shin, G., Jarrahi, M. H., Fei, Y., Karami, A., Gafinowitz, N., Byun, A., & Lu, X. (2019) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2019.103153 · Cited by 326 · see citing works
Tudor-Locke, C. E., Camhi, S. M., & Troiano, R. P. (2012) · Preventing Chronic Disease · doi:10.5888/pcd9.110332 · Cited by 319 · see citing works
Daily physical activity assessment with accelerometers: new insights and validation studies
Plasqui, G., Bonomi, A. G., & Westerterp, K. R. (2013) · Obesity Reviews · doi:10.1111/obr.12021 · Cited by 315 · see citing works
The Effects of Breaking up Prolonged Sitting Time
Benatti, F. B., & Ried‐Larsen, M. (2015) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000654 · Cited by 312 · see citing works
Replacing sitting time with standing or stepping: associations with cardio-metabolic risk biomarkers
Healy, G. N., WINKLER, E. A. H., Owen, N. G., Anuradha, S., & Dunstan, D. W. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv308 · Cited by 306 · see citing works
Self-citationSabia, S., van Hees, V. T., Shipley, M. J., Trenell, M. I., Hagger-Johnson, G., Elbaz, A., Kivimaki, M., & Singh-Manoux, A. (2014) · American Journal of Epidemiology · doi:10.1093/aje/kwt330 · Cited by 304 · see citing works
Cliff, D. P., Hesketh, K. D., Vella, S. A., Hinkley, T., Tsiros, M. D., Ridgers, N. D., Carver, A., Veitch, J., Parrish, A., Hardy, L. L., et al. (2016) · Obesity Reviews · doi:10.1111/obr.12371 · Cited by 306 · see citing works
The effect of physical activity on mediators of inflammation
Nimmo, M. A., Leggate, M., Viana, J. L., & King, J. A. (2013) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12156 · Cited by 301 · see citing works
van der Berg, J. D., Stehouwer, C. D. A., Bosma, H., van der Velde, J. H. P. M., Willems, P. J. B., Savelberg, H. H. C. M., Schram, M. T., Sep, S. J. S., van der Kallen, C. J. H., Henry, R. M. A., et al. (2016) · Diabetologia · doi:10.1007/s00125-015-3861-8 · Cited by 299 · see citing works
A Cluster Randomized Controlled Trial to Reduce Office Workers’ Sitting Time
Healy, G. N., Eakin, E., Owen, N. G., LaMontagne, A. D., Moodie, M., WINKLER, E. A. H., Fjeldsoe, B. S., Wiesner, G., Willenberg, L., & Dunstan, D. W. (2016) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000972 · Cited by 298 · see citing works
Self-citationSedentary Behavior, Physical Activity, and Markers of Health in Older Adults
GENNUSO, K. P., GANGNON, R. E., MATTHEWS, C. E., THRAEN-BOROWSKI, K. M., & COLBERT, L. H. (2013) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318288a1e5 · Cited by 292 · see citing works
Self-citationGianoudis, J., Bailey, C. A., & Daly, R. M. (2014) · Osteoporosis International · doi:10.1007/s00198-014-2895-y · Cited by 293 · see citing works
English, C., Manns, P. J., Tucak, C., & Bernhardt, J. (2014) · Physical Therapy · doi:10.2522/ptj.20130175 · Cited by 278 · see citing works
Stamatakis, E., Ekelund, U., Ding, D., Hamer, M., Bauman, A. E., & Lee, I.-M. (2019) · British Journal of Sports Medicine · doi:10.1136/bjsports-2018-099131 · Cited by 284 · see citing works
Validity of Two Wearable Monitors to Estimate Breaks from Sedentary Time
Lyden, K. A., Keadle, S. K., STAUDENMAYER, J. W., & Freedson, P. S. (2012) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318260c477 · Cited by 284 · see citing works
Ortega, F. B., Konstabel, K., Pasquali, E., Ruiz, J. R., Hurtig-Wennlöf, A., Mäestu, J., Löf, M., Harro, J., Bellocco, R., Labayen, I., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060871 · Cited by 281 · see citing works
Definition, Measurement, and Health Risks Associated with Sedentary Behavior
Gibbs, B. B., Hergenroeder, A. L., Katzmarzyk, P. T., Lee, I.-M. M., & Jakicic, J. M. (2014) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000517 · Cited by 275 · see citing works
Sedentary Behavior and Cardiovascular Disease Risk: Mediating Mechanisms
Carter, S. E., Hartman, Y., Holder, S. M., Thijssen, D. H. J., & Hopkins, N. D. (2017) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000106 · Cited by 271 · see citing works
Henson, J., Davies, M. J., Bodicoat, D. H., Edwardson, C. L., Gill, J. M. R., Stensel, D. J., Tolfrey, K., Dunstan, D. W., Khunti, K., & Yates, T. (2016) · Diabetes Care · doi:10.2337/dc15-1240 · Cited by 270 · see citing works
Self-citationMcConnell, M. V., Shcherbina, A., Pavlovic, A., Homburger, J. R., Goldfeder, R. L., Waggot, D., Cho, M. K., Rosenberger, M. E., Haskell, W. L., Myers, J., et al. (2017) · JAMA Cardiology · doi:10.1001/jamacardio.2016.4395 · Cited by 239 · see citing works
Pedišić, Ž., Bennie, J. A., Timperio, A. F., Crawford, D. A., Dunstan, D. W., Bauman, A. E., & Salmon, J. (2014) · BMC Public Health · doi:10.1186/1471-2458-14-1249 · Cited by 254 · see citing works
Self-citationFeasibility of Reducing Older Adults' Sedentary Time
Gardiner, P. A., Eakin, E., Healy, G. N., & Owen, N. G. (2011) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2011.03.020 · Cited by 246 · see citing works
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Biddle, S., García, E. B., Pedišić, Ž., Bennie, J. A., Vergeer, I., & Wiesner, G. (2017) · Current Obesity Reports · doi:10.1007/s13679-017-0256-9 · Cited by 250 · see citing works
Sedentariness and Health: Is Sedentary Behavior More Than Just Physical Inactivity?
Panahi, S., & Tremblay, A. (2018) · Frontiers in Public Health · doi:10.3389/fpubh.2018.00258 · Cited by 249 · see citing works
Estimating Activity and Sedentary Behavior from an Accelerometer on the Hip or Wrist
Rosenberger, M. E., Haskell, W. L., Albinali, F., Mota, S., Nawyn, J., & Intille, S. S. (2013) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31827f0d9c · Cited by 242 · see citing works
Vallance, J. K., Winkler, E. A. H., Gardiner, P. A., Healy, G. N., Lynch, B. M., & Owen, N. (2011) · Preventive Medicine · doi:10.1016/j.ypmed.2011.07.013 · Cited by 238 · see citing works
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Lyden, K. A., Keadle, S. K., STAUDENMAYER, J. W., & Freedson, P. S. (2016) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001177 · Cited by 229 · see citing works
Accelerometer-measured sedentary time and cardiometabolic biomarkers: A systematic review
Brocklebank, L. A., Falconer, C., Page, A. S., Perry, R. A., & Cooper, A. R. (2015) · Preventive Medicine · doi:10.1016/j.ypmed.2015.04.013 · Cited by 227 · see citing works
Sitting and Activity Time in People With Stroke
English, C., Healy, G. N., Coates, A. M., Lewis, L. K., Olds, T., & Bernhardt, J. A. (2015) · Physical Therapy · doi:10.2522/ptj.20140522 · Cited by 226 · see citing works
Self-citationSitting patterns at work: objective measurement of adherence to current recommendations
Ryan, C. G., Dall, P., Granat, M. H., & Grant, P. (2011) · Ergonomics · doi:10.1080/00140139.2011.570458 · Cited by 226 · see citing works
Saunders, T. J., & Vallance, J. K. (2016) · Applied Health Economics and Health Policy · doi:10.1007/s40258-016-0289-3 · Cited by 223 · see citing works
Sedentary Time and Markers of Chronic Low-Grade Inflammation in a High Risk Population
Henson, J. J., Yates, T. E., Edwardson, C. L., Khunti, K. K., Talbot, D. C. S., Gray, L. J., Leigh, T. M., Carter, P., & Davies, M. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078350 · Cited by 219 · see citing works
Sitting Time and Risk of Cardiovascular Disease and Diabetes: A Systematic Review and Meta-Analysis
Bailey, D. P., Hewson, D. J., Champion, R. B., & Sayegh, S. (2019) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2019.04.015 · Cited by 219 · see citing works
Sedentary behaviour and life expectancy in the USA: a cause-deleted life table analysis
Katzmarzyk, P. T., & Lee, I.-M. (2012) · BMJ Open · doi:10.1136/bmjopen-2012-000828 · Cited by 218 · see citing works
Workplace Sitting and Height-Adjustable Workstations
Neuhaus, M., Healy, G. N., Dunstan, D. W., Owen, N. G., & Eakin, E. (2013) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2013.09.009 · Cited by 216 · see citing works
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Thorp, A. A., Kingwell, B. A., Sethi, P., Hammond, L. J., Owen, N. G., & Dunstan, D. W. (2014) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000337 · Cited by 215 · see citing works
Self-citationHughson, R. L., Robertson, A. D., Arbeille, P., Shoemaker, J. K., Rush, J. W. E., Fraser, K. S., & Greaves, D. K. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00802.2015 · Cited by 209 · see citing works
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Owen, N. G., Healy, G. N., Dempsey, P. C., Salmon, J., Timperio, A. F., Clark, B., Goode, A. D., Koorts, H., Ridgers, N. D., Hadgraft, N. T., et al. (2020) · Annual Review of Public Health · doi:10.1146/annurev-publhealth-040119-094201 · Cited by 206 · see citing works
Self-citationPoint-of-Choice Prompts to Reduce Sitting Time at Work
Evans, R. E., Fawole, H. O., Sheriff, S. A., Dall, P., Grant, P., & Ryan, C. G. (2012) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2012.05.010 · Cited by 204 · see citing works
Bond, D. S., Thomas, J. G., Raynor, H. A., Moon, J., Sieling, J., Trautvetter, J., Leblond, T. L., & Wing, R. R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100821 · Cited by 202 · see citing works
Cooper, A. R., Sebire, S., Montgomery, A. A., Peters, T. J., Sharp, D. J., Jackson, N., Fitzsimons, K., Dayan, C. M., & Andrews, R. C. (2012) · Diabetologia · doi:10.1007/s00125-011-2408-x · Cited by 195 · see citing works
Agreement between activPAL and ActiGraph for assessing children's sedentary time
Ridgers, N. D., Salmon, J., Ridley, K., O'Connell, E., Arundell, L., & Timperio, A. F. (2012) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/1479-5868-9-15 · Cited by 193 · see citing works
Sedentary behavior: Understanding and influencing adults' prolonged sitting time
Owen, N. (2012) · Preventive Medicine · doi:10.1016/j.ypmed.2012.08.024 · Cited by 187 · see citing works
Self-citationWheeler, M. J., Dempsey, P. C., Grace, M. S., Ellis, K. A., Gardiner, P. A., GREEN, D. J., & Dunstan, D. W. (2017) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2017.04.001 · Cited by 186 · see citing works
Self-citationSedentary behavior as a mediator of type 2 diabetes
Hamilton, M. T., Hamilton, D. G., & Zderic, T. W. (2014) · Medicine and Sport Science · doi:10.1159/000357332 · Cited by 185 · see citing works
Saunders, T. J., Tremblay, M. S., Mathieu, M.-E., Henderson, M., O’Loughlin, J. L., Tremblay, A., & Chaput, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079143 · Cited by 184 · see citing works
Hadgraft, N. T., WINKLER, E. A. H., Climie, R. E., Grace, M. S., Romero, L., Owen, N. G., Dunstan, D. W., Healy, G. N., & Dempsey, P. C. (2020) · British Journal of Sports Medicine · doi:10.1136/bjsports-2019-101154 · Cited by 180 · see citing works
Self-citationMeasuring Older Adults' Sedentary Time
Gardiner, P. A., Clark, B., Healy, G. N., Eakin, E., WINKLER, E. A. H., & Owen, N. G. (2011) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31821b94f7 · Cited by 176 · see citing works
Self-citationAccelerometer-based Physical Activity
Bassett, D. R., Troiano, R. P., McClain, J. J., & Wolff, D. L. (2014) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000468 · Cited by 177 · see citing works
Managing Sedentary Behavior to Reduce the Risk of Diabetes and Cardiovascular Disease
Dempsey, P. C., Owen, N. G., Biddle, S., & Dunstan, D. W. (2014) · Current Diabetes Reports · doi:10.1007/s11892-014-0522-0 · Cited by 176 · see citing works
Self-citationDempsey, P. C., Sacre, J. W., Larsen, R. N., Straznicky, N. E., Sethi, P., Cohen, N. D., Cerin, E., Lambert, G. W., Owen, N., Kingwell, B. A., et al. (2016) · Journal of Hypertension · doi:10.1097/hjh.0000000000001101 · Cited by 173 · see citing works
Self-citationSedentary Behavior and Physical Function: Objective Evidence From the Osteoarthritis Initiative
Lee, J. J., Chang, R. W., Ehrlich‐Jones, L., Kwoh, C. K., Nevitt, M. C., Semanik, P. A., Sharma, L., Sohn, M., Song, J., & Dunlop, D. D. (2014) · Arthritis Care & Research · doi:10.1002/acr.22432 · Cited by 173 · see citing works
Patterns of sedentary time and cardiometabolic risk among Canadian adults
Carson, V., Wong, S. L., Winkler, E., Healy, G. N., Colley, R. C., & Tremblay, M. S. (2014) · Preventive Medicine · doi:10.1016/j.ypmed.2014.04.005 · Cited by 172 · see citing works
Self-citationSmith, L., Hamer, M., Ucci, M., Marmot, A., Gardner, B., Sawyer, A. D. M., Wardle, J., & Fisher, A. (2015) · BMC Public Health · doi:10.1186/s12889-014-1338-1 · Cited by 171 · see citing works
Patterns of Sedentary Behavior in US Middle-Age and Older Adults: The REGARDS Study
DIAZ, K. M., HOWARD, V. J., HUTTO, B., COLABIANCHI, N., VENA, J. E., BLAIR, S. N., & HOOKER, S. P. (2016) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000792 · Cited by 170 · see citing works
Bellettiere, J., Winkler, E. A. H., Chastin, S. F. M., Kerr, J., Owen, N., Dunstan, D. W., & Healy, G. N. (2017) · PLOS ONE · doi:10.1371/journal.pone.0180119 · Cited by 169 · see citing works
Self-citationProlonged sitting: is it a distinct coronary heart disease risk factor?
Dunstan, D. W., Thorp, A. A., & Healy, G. N. (2011) · Current Opinion in Cardiology · doi:10.1097/hco.0b013e3283496605 · Cited by 166 · see citing works
Self-citationVoss, M. W., Carr, L. J., Clark, R., & Weng, T. (2014) · Mental health and physical activity · doi:10.1016/j.mhpa.2014.01.001 · Cited by 164 · see citing works
Association of Sedentary Behavior With Cancer Mortality in Middle-aged and Older US Adults
Gilchrist, S. C., Howard, V. J., Akinyemiju, T., Judd, S. E., Cushman, M., Hooker, S. P., & Diaz, K. M. (2020) · JAMA Oncology · doi:10.1001/jamaoncol.2020.2045 · Cited by 163 · see citing works
Parry, S. P., Straker, L. M., Gilson, N. D., & Smith, A. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078957 · Cited by 167 · see citing works
Dunstan, D. W., Wiesner, G., Eakin, E., Neuhaus, M., Owen, N. G., LaMontagne, A. D., Moodie, M., WINKLER, E. A. H., Fjeldsoe, B. S., Lawler, S., et al. (2013) · BMC Public Health · doi:10.1186/1471-2458-13-1057 · Cited by 161 · see citing works
Self-citationDempsey, P. C., Owen, N. G., Yates, T. E., Kingwell, B. A., & Dunstan, D. W. (2016) · Current Diabetes Reports · doi:10.1007/s11892-016-0797-4 · Cited by 160 · see citing works
Self-citationWullems, J. A., Verschueren, S., Degens, H., Morse, C. I., & Onambélé-Pearson, G. L. (2016) · Biogerontology · doi:10.1007/s10522-016-9640-1 · Cited by 160 · see citing works
The Ubiquity of the Screen: An Overview of the Risks and Benefits of Screen Time in Our Modern World
LeBlanc, A. G., Gunnell, K. E., Prince, S. A., Saunders, T. J., Barnes, J. D., & Chaput, J. (2017) · Translational Journal of the American College of Sports Medicine · doi:10.1249/tjx.0000000000000039 · Cited by 160 · see citing works
Santos, R., Mota, J. A. P. S., Okely, A. D., Pratt, M., Moreira, C. M. M., Coelho-e-Silva, M. J., Vale, S. M. C. G., & Sardinha, L. B. (2013) · British Journal of Sports Medicine · doi:10.1136/bjsports-2012-091610 · Cited by 161 · see citing works
Schmid, D., Ricci, C., & Leitzmann, M. F. (2015) · PLoS ONE · doi:10.1371/journal.pone.0119591 · Cited by 158 · see citing works
Paul, L., Wyke, S., Brewster, S. A., Sattar, N. A., Gill, J. M. R., Alexander, G., Rafferty, D., McFadyen, A. K., Ramsay, A., & Dybus, A. (2016) · Topics in Stroke Rehabilitation · doi:10.1080/10749357.2015.1122266 · Cited by 158 · see citing works
CHASTIN, S. F. M., Craemer, M. D., Lien, N., Bernaards, C. M., Buck, C., Oppert, J., Nazare, J., Lakerveld, J., O’Donoghue, G., Holdsworth, M., et al. (2016) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/s12966-016-0409-3 · Cited by 157 · see citing works
Self-citation
- Authors
- Healy, G. N., Matthews, C. E., Dunstan, D. W., Winkler, E. A. H., & Owen, N.
- Affiliations
- Baker Heart and Diabetes Institute (AU)
- National Cancer Institute (US)
- The University of Queensland (AU)
- Corresponding author
- Healy, Genevieve N.
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-01-11
- Volume
- 32
- Issue
- 5
- Pages
- 590-597
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- PMC
- PMC3634159
- OpenAlex
- W2150722389
- Cited by
- 1,368
- References
- 28
- Citations by year
- 2026: 21 · 2025: 31 · 2024: 49 · 2023: 57 · 2022: 80 · 2021: 94 · 2020: 106 · 2019: 102 · 2018: 104 · 2017: 125 · 2016: 112 · 2015: 146 · 2014: 135 · 2013: 102 · 2012: 71
- FWCI
- 73.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Heart Journal (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Bank (Australian Catholic University) (submittedVersion)
- eSpace (Curtin University) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Swinburne figshare (Swinburne University of Technology) (submittedVersion)
- Funders
- National Institutes of Health (Z99 CA999999)
- Topics
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Keywords
- sedentary behavior, sedentary breaks, cardiometabolic risk, inflammatory markers, C-reactive protein, waist circumference, HDL cholesterol, triglycerides, insulin, HOMA-IR, HOMA-β, accelerometer-measured sedentary time, sex differences, racial and ethnic differences, cardiovascular risk, NHANES
- MeSH terms
- Acceleration, Adult, Aged, Blood Pressure, Cardiovascular Diseases, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Nutrition Surveys, Smoking, United States, Biomarkers, Age Distribution, Sex Distribution, Waist Circumference, Sedentary Behavior
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