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Cited by 34Cardiovascular Health and Disease PreventionCerebrovascular and Carotid Artery DiseasesCardiac Imaging and Diagnostics

Short-term progression of maximum intima-media thickness of carotid plaque is associated with future coronary events in patients with coronary artery disease

Hirano, Mitsumasa, Nakamura, Takamitsu, Kitta, Yoshinobu, Takishima, Isao, Deyama, Juntaro, Kobayashi, Tsuyoshi, Fujioka, Daisuke, Saito, Yukio +5 more·2011·Atherosclerosis
DOI 10.1016/j.atherosclerosis.2011.01.014
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Abstract

Objective This study examined whether changes in maximum intima-media thickness of carotid plaque (plaque-IMTmax) over 6 months predict future coronary events in patients with carotid plaque and coronary artery disease (CAD).Methods This study included 240 patients with CAD who had a carotid plaque (IMT ≥ 1.1mm) at entry. A carotid ultrasound examination was performed at entry (1st test) and after 6 months (2nd test). The carotid plaque with the greatest axial thickness at the 1st test was selected as the target plaque for monitoring the change in plaque-IMTmax. After the 2nd test, patients were prospectively followed-up for 3 years or until the occurrence of one of the following coronary events: cardiac death, non-fatal myocardial infarction, or unstable angina pectoris requiring coronary revascularization.Results The change in plaque-IMTmax over 6 months ranged from -0.85 to 0.97 mm (mean, -0.006 ± 0.319 mm). There were 41 events during follow-up. In a stepwise multivariate Cox proportional hazards model, the change in plaque-IMTmax was a significant predictor of coronary events after adjustment for known risk factors (HR per 0.1mm increase over 6 months, 1.21; 95%CI, 1.10-1.33, p=0.0001). Analysis of receiver operating characteristic (ROC) curves showed that the addition of the change in plaque-IMTmax to conventional risk factors resulted in a greater area under the ROC curve compared with conventional risk factors alone (0.81 and 0.70, respectively, p=0.02).Conclusion Short-term progression of carotid plaque-IMTmax was associated with future coronary events in patients with CAD.

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Authors
Hirano, M., Nakamura, T., Kitta, Y., Takishima, I., Deyama, J., Kobayashi, T., Fujioka, D., Saito, Y., Watanabe, K., Watanabe, Y., Kawabata, K.-I., Obata, J.-E., & Kugiyama, K.
Affiliations
University of Yamanashi Hospital (JP)
Corresponding author
Kugiyama, Kiyotaka
ORCID
Venue
Atherosclerosis
Publisher
Elsevier BV
Published
2011-04
Volume
215
Issue
2
Pages
507-512
ISSN
0021-9150 (ISSN-L)
DOI
10.1016/j.atherosclerosis.2011.01.014
OpenAlex
W1994828423
Cited by
34
References
33
Citations by year
2026: 2 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 3 · 2018: 4 · 2017: 1 · 2016: 3 · 2015: 3 · 2014: 3 · 2013: 4 · 2012: 1
FWCI
1.75
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Atherosclerosis (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cerebrovascular and Carotid Artery Diseases
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
Keywords
carotid intima-media thickness, carotid plaque, plaque progression, coronary artery disease, coronary events, myocardial infarction, unstable angina, cardiovascular risk prediction, carotid ultrasound
MeSH terms
Aged, Carotid Arteries, Coronary Artery Disease, Coronary Disease, Female, Humans, Male, Middle Aged, Risk Factors, Ultrasonography, Tunica Intima, Tunica Media, Disease Progression, Plaque, Atherosclerotic

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