The DOI matches its Crossref record; 98 of the 98 references it cites were found in a registry or an index.
Periodontitis and blood pressure: The concept of dental hypertension
Abstract
Chronic periodontitis is a common inflammatory disorder that is being contemplated as a risk factor for atherosclerotic complications. Current epidemiological evidence also supports its potential association with increases in blood pressure levels and hypertension prevalence. Furthermore, data from cross-sectional studies suggest that in hypertensive subjects periodontitis may enhance the risk and degree of target organ damage. A possible pathogenetic background of an effect of periodontitis on blood pressure should include the systemic generalization of the local oral inflammation, the role of the host immune response, the direct microbial effect on the vascular system and alterations in endothelial function. Inversely, the concept of hypertension unfavorably affecting periodontal tissues cannot be excluded. The two conditions share multiple common risk factors that should be readily controlled for when assessing a possible association. Thoroughly designed prospective and interventional trials are needed in order to determine the impact of periodontitis on blood pressure regulation and incident hypertension and its integration in the clinical approach of both dental and hypertensive patients.
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“Several studies appear to support a relationship between severe periodontitis and hypertension.[24][25][26][27]”
From Periodontitis is associated with hypertension: a systematic review and meta-analysis (2020) · cites this paper as [25]
Citations
Cites
Treatment of periodontitis and endothelial function
Tonetti, M. S., D'Aiuto, F., Nibali, L., Donald, A., Storry, C., Parkar, M., Suvan, J., Hingorani, A. D., Vallance, P., & Deanfield, J. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa063186 · Cited by 1,326
C-Reactive Protein and the Risk of Developing Hypertension
Sesso, H. D. (2003) · JAMA · doi:10.1001/jama.290.22.2945 · Cited by 1,013
Reactive Oxygen Species, Vascular Oxidative Stress, and Redox Signaling in Hypertension
Touyz, R. M. (2004) · Hypertension · doi:10.1161/01.hyp.0000138070.47616.9d · Cited by 870
Loos, B. G., Craandijk, J., Hoek, F. J., Dillen, P. M. E. W., & van der Velden, U. (2000) · Journal of Periodontology · doi:10.1902/jop.2000.71.10.1528 · Cited by 810
A systematic review and meta‐analyses on C‐reactive protein in relation to periodontitis
Paraskevas, S., Huizinga, J. D., & Loos, B. G. (2008) · Journal of Clinical Periodontology · doi:10.1111/j.1600-051x.2007.01173.x · Cited by 757
Effect of Periodontal Treatment on Glycemic Control of Diabetic Patients
Teeuw, W. J., Gerdes, V. E. A., & Loos, B. G. (2010) · Diabetes Care · doi:10.2337/dc09-1378 · Cited by 526
Meta-analysis of periodontal disease and risk of coronary heart disease and stroke
Janket, S., Baird, A. E., Chuang, S.-K., & Jones, J. A. (2003) · Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology · doi:10.1067/moe.2003.107 · Cited by 501
Vlachopoulos, C., Dima, I., Aznaouridis, K., Vasiliadou, C., Ioakeimidis, N., Aggeli, C., Toutouza, M., & Stefanadis, C. (2005) · Circulation · doi:10.1161/circulationaha.105.535435 · Cited by 492
Self-citationPeriodontal Disease and Coronary Heart Disease Risk
Hujoel, P. P. (2000) · JAMA · doi:10.1001/jama.284.11.1406 · Cited by 491
Kozarov, E. V., Dorn, B. R., Shelburne, C. E., Dunn, W. A., & Progulske‐Fox, A. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000155018.67835.1a · Cited by 476
Cited by
Sorted by citations
Diabetes and Hypertension: Is There a Common Metabolic Pathway?
Cheung, B. M. Y., & Li, C. (2012) · Current Atherosclerosis Reports · doi:10.1007/s11883-012-0227-2 · Cited by 606
Periodontitis is associated with hypertension: a systematic review and meta-analysis
Muñoz Aguilera, E., Suvan, J., Buti, J., Czesnikiewicz-Guzik, M., Barbosa Ribeiro, A., Orlandi, M., Guzik, T. J., Hingorani, A. D., Nart, J., & D’Aiuto, F. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvz201 · Cited by 394
Evaluating All Potential Oral Complications of Diabetes Mellitus
Verhulst, M. J. L., Loos, B. G., Gerdes, V. E. A., & Teeuw, W. J. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00056 · Cited by 294
Periodontal disease and the metabolic syndrome
Lamster, I. B., & Pagan, M. (2016) · International Dental Journal · doi:10.1111/idj.12264 · Cited by 195
Association between periodontitis and arterial hypertension: a systematic review and meta-analysis
Martin-Cabezas, R., Seelam, N., Petit, C., Agossa, K., Gaertner, S., Tenenbaum, H., Davideau, J.-L., & Huck, O. (2016) · American Heart Journal · doi:10.1016/j.ahj.2016.07.018 · Cited by 183
Metadata
- Authors
- Tsioufis, C., Kasiakogias, A., Thomopoulos, C., & Stefanadis, C.
- Affiliations
- National and Kapodistrian University of Athens (GR)
- Corresponding author
- Tsioufis, Costas
- Venue
- Atherosclerosis
- Publisher
- Elsevier BV
- Published
- 2011-11
- Volume
- 219
- Issue
- 1
- Pages
- 1-9
- ISSN
- 0021-9150 (ISSN-L)
- OpenAlex
- W2119224792
- Cited by
- 142
- References
- 98
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 7 · 2023: 10 · 2022: 15 · 2021: 11 · 2020: 11 · 2019: 11 · 2018: 9 · 2017: 9 · 2016: 10 · 2015: 8 · 2014: 8 · 2013: 14 · 2012: 7
- FWCI
- 1.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Atherosclerosis (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Dentistry › General Dentistry › Dental Research and COVID-19
- Keywords
- chronic periodontitis, hypertension, blood pressure, systemic inflammation, host immune response, endothelial function, target organ damage
- MeSH terms
- Animals, Blood Pressure, Humans, Hypertension, Inflammation, Insulin Resistance, Periodontitis, Periodontium, Risk Factors, Hypertrophy, Left Ventricular, Oxidative Stress, Inflammation Mediators, Atherosclerosis, Vascular Stiffness
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