Cited by 142Oral microbiology and periodontitis researchBlood Pressure and Hypertension StudiesDental Research and COVID-19

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Periodontitis and blood pressure: The concept of dental hypertension

Tsioufis, Costas, Kasiakogias, Alexandros, Thomopoulos, Costas, Stefanadis, Christodoulos·2011·Atherosclerosis

DOI 10.1016/j.atherosclerosis.2011.04.030

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Abstract

Chronic periodontitis is a common inflammatory disorder that is being contemplated as a risk factor for atherosclerotic complications. Current epidemiological evidence also supports its potential association with increases in blood pressure levels and hypertension prevalence. Furthermore, data from cross-sectional studies suggest that in hypertensive subjects periodontitis may enhance the risk and degree of target organ damage. A possible pathogenetic background of an effect of periodontitis on blood pressure should include the systemic generalization of the local oral inflammation, the role of the host immune response, the direct microbial effect on the vascular system and alterations in endothelial function. Inversely, the concept of hypertension unfavorably affecting periodontal tissues cannot be excluded. The two conditions share multiple common risk factors that should be readily controlled for when assessing a possible association. Thoroughly designed prospective and interventional trials are needed in order to determine the impact of periodontitis on blood pressure regulation and incident hypertension and its integration in the clinical approach of both dental and hypertensive patients.

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Authors: Tsioufis, C., Kasiakogias, A., Thomopoulos, C., & Stefanadis, C.
Affiliations: National and Kapodistrian University of Athens (GR)
Corresponding author: Tsioufis, Costas
ORCID: Kasiakogias, Alexandros
Thomopoulos, Costas
Stefanadis, Christodoulos
Venue: Atherosclerosis
Publisher: Elsevier BV
Published: 2011-11
Volume: 219
Issue: 1
Pages: 1-9
ISSN: 0021-9150 (ISSN-L)
DOI: 10.1016/j.atherosclerosis.2011.04.030
OpenAlex: W2119224792
Cited by: 142
References: 98
Citations by year: 2026: 5 · 2025: 6 · 2024: 7 · 2023: 10 · 2022: 15 · 2021: 11 · 2020: 11 · 2019: 11 · 2018: 9 · 2017: 9 · 2016: 10 · 2015: 8 · 2014: 8 · 2013: 14 · 2012: 7
FWCI: 1.57
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Atherosclerosis (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Health Sciences › Dentistry › General Dentistry › Dental Research and COVID-19
Keywords: chronic periodontitis, hypertension, blood pressure, systemic inflammation, host immune response, endothelial function, target organ damage
MeSH terms: Animals, Blood Pressure, Humans, Hypertension, Inflammation, Insulin Resistance, Periodontitis, Periodontium, Risk Factors, Hypertrophy, Left Ventricular, Oxidative Stress, Inflammation Mediators, Atherosclerosis, Vascular Stiffness

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Periodontitis and blood pressure: The concept of dental hypertension

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