Significant differential effects of omega-3 fatty acids and fenofibrate in patients with hypertriglyceridemia
Abstract
Background Omega-3 fatty acids and fenofibrate are both used to treat patients with hypertriglyceridemia. However, a head-to-head comparison of the lipoprotein and metabolic effects of these two medicines has not been published. Methods This was a randomized, single-blind, placebo-controlled, parallel study. Age, sex, and body mass index were matched among groups. All patients were recommended to maintain a low fat diet. Fifty patients in each group were given placebo, omega-3 fatty acids 2 g (most commonly used dosage in Korean patients), or fenofibrate 160 mg, respectively daily for 2 months. Results Omega-3 fatty acids therapy decreased triglycerides by 21% and triglycerides/HDL cholesterol and improved flow-mediated dilation (P Conclusions Omega-3 fatty acids and fenofibrate therapy promoted similar changes in triglycerides and endothelium-dependent dilation. However, fenofibrate therapy had substantially better effects on lipoprotein and metabolic profiles in patients with hypertriglyceridemia.
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An earlier open-label study found that 2 g/d IPE decreased triglycerides by only 5%.
“An earlier open-label study of 2 g/d IPE found that triglycerides decreased only 5%.69”
From Omega-3 Fatty Acids for the Management of Hypertriglyceridemia: A Science Advisory From the American Heart Association (2019) · cites this paper as [69]
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References 51 · Cited by 61
- Authors
- Koh, K. K., Quon, M. J., Shin, K.-C., Lim, S., Lee, Y., Sakuma, I., Lee, K., Han, S. H., & Shin, E. K.
- Affiliations
- Gachon University Gil Medical Center (KR)
- University of Maryland, Baltimore (US)
- Seoul National University (KR)
- University of Seoul (KR)
- Hokko Memorial Hospital (JP)
- Venue
- Atherosclerosis
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 220
- Issue
- 2
- Pages
- 537-544
- ISSN
- 0021-9150 (ISSN-L)
- OpenAlex
- W1977306373
- Cited by
- 61
- References
- 51
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 6 · 2018: 2 · 2017: 2 · 2016: 7 · 2015: 7 · 2014: 6 · 2013: 9 · 2012: 1
- FWCI
- 4.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Atherosclerosis (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Gil Medical Center, Gachon University
- National Center for Complementary and Alternative Medicine
- National Institutes of Health
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- omega-3 fatty acids, fenofibrate, hypertriglyceridemia, triglycerides, HDL cholesterol, non-HDL cholesterol, apolipoprotein A-I, flow-mediated dilation, endothelial function, adiponectin, insulin sensitivity, lipoprotein metabolism
- MeSH terms
- Analysis of Variance, Hypolipidemic Agents, Blood Glucose, C-Reactive Protein, Female, Fibrinogen, Glycated Hemoglobin, Humans, Insulin, Insulin Resistance, Cholesterol, HDL, Male, Middle Aged, Fenofibrate, Time Factors, Triglycerides, Vasodilation, Hypertriglyceridemia, Biomarkers, Fatty Acids, Omega-3, Single-Blind Method, Apolipoprotein A-I, Treatment Outcome, Inflammation Mediators, Dietary Supplements, Adiponectin, Republic of Korea
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