Increased atherosclerosis in mice with increased vascular biglycan content
Open accessAbstract
Objective The response to retention hypothesis of atherogenesis proposes that atherosclerosis is initiated via the retention of atherogenic lipoproteins by vascular proteoglycans. Co-localization studies suggest that of all the vascular proteoglycans, biglycan is the one most closely co-localized with LDL. The goal of this study was to determine if over-expression of biglycan in hyperlipidemic mice would increase atherosclerosis development.Methods Transgenic mice were developed by expressing biglycan under control of the smooth muscle actin promoter, and were crossed to the LDL receptor deficient (C57BL/6 background) atherosclerotic mouse model. Biglycan transgenic and non-transgenic control mice were fed an atherogenic Western diet for 4-12 weeks.Results LDL receptor deficient mice overexpressing biglycan under control of the smooth muscle alpha actin promoter had increased atherosclerosis development that correlated with vascular biglycan content.Conclusion Increased vascular biglycan content predisposes to increased lipid retention and increased atherosclerosis development.
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Transgenic mice over-expressing biglycan in VSMCs show more lipid retention and increased atherosclerosis than wild-type litter-mates.
“Transgenic mice over-expressing biglycan in VSMCs show more lipid retention and increased atherosclerosis than wild-type litter-mates 114 .”
From Vascular smooth muscle cells in atherosclerosis (2019) · cites this paper as [114]
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Cites
The Response-to-Retention Hypothesis of Early Atherogenesis
Williams, K. J., & Tabas, I. (1995) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.15.5.551 · Cited by 1,413 · see citing works
Subendothelial retention of atherogenic lipoproteins in early atherosclerosis
Skålén, K., Gustafsson, M., Rydberg, E. K., Hultén, L. M., Wiklund, O., Innerarity, T. L., & Borén, J. (2002) · Nature · doi:10.1038/nature00804 · Cited by 1,019 · see citing works
Developmental Basis of Vascular Smooth Muscle Diversity
Majesky, M. W. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.141069 · Cited by 737 · see citing works
Site Specificity of Atherosclerosis
VanderLaan, P. A., Reardon, C. A., & Getz, G. S. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000105054.43931.f0 · Cited by 570 · see citing works
Nakashima, Y., Fujii, H., Sumiyoshi, S., Wight, T. N., & Sueishi, K. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.106.134080 · Cited by 435 · see citing works
Schwenke, D. C., & Carew, T. E. (1989) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.9.6.908 · Cited by 344 · see citing works
Increased Renal Production of Transforming Growth Factor-β1 in Patients with Type II Diabetes
Sharma, K., Ziyadeh, F. N., Alzahabi, B., McGowan, T., Kapoor, S. C., Kurnik, B. R. C., Kurnik, P. B., & Weisberg, L. S. (1997) · Diabetes · doi:10.2337/diab.46.5.854 · Cited by 274 · see citing works
Biological interplay between proteoglycans and their innate immune receptors in inflammation
Frey, H., Schroeder, N., Manon‐Jensen, T., Iozzo, R. V., & Schaefer, L. (2013) · FEBS Journal · doi:10.1111/febs.12145 · Cited by 272 · see citing works
Schwenke, D. C., & Carew, T. E. (1989) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.9.6.895 · Cited by 272 · see citing works
Comparison of Apolipoprotein and Proteoglycan Deposits in Human Coronary Atherosclerotic Plaques
O’Brien, K. D., Olin, K. L., Alpers, C. E., Chiu, W. S., Ferguson, M. S., Hudkins, K. L., Wight, T. N., & Chait, A. (1998) · Circulation · doi:10.1161/01.cir.98.6.519 · Cited by 271 · see citing works
Triglycerides and Heart Disease
Goldberg, I. J., Eckel, R. H., & McPherson, R. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.226100 · Cited by 219 · see citing works
Lee, R. T., Yamamoto, C., Feng, Y., Potter‐Perigo, S., Briggs, W. H., Landschulz, K. T., Turi, T. G., Thompson, J. F., Libby, P., & Wight, T. N. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010556200 · Cited by 184 · see citing works
Self-citationKinsella, M. G., Bressler, S. L., & Wight, T. N. (2004) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukaryotgeneexpr.v14.i3.40 · Cited by 183 · see citing works
Elevated Plasma Levels of Transforming Growth Factor-β1 in NIDDM
Pfeiffer, A. F. H., Middelberg-Bisping, K., Drewes, C., & Schatz, H. (1996) · Diabetes Care · doi:10.2337/diacare.19.10.1113 · Cited by 126 · see citing works
Kunjathoor, V. V., Chiu, D. S., O’Brien, K. D., & LeBoeuf, R. C. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq0302.105378 · Cited by 110 · see citing works
Wasty, F., ALAVI, M. Z., & Moore, S. (1993) · Diabetologia · doi:10.1007/bf00400234 · Cited by 107 · see citing works
Shimizu‐Hirota, R., Sasamura, H., Kuroda, M., Kobayashi, E., Hayashi, M., & Saruta, T. (2004) · Circulation Research · doi:10.1161/01.res.0000126049.79800.ca · Cited by 98 · see citing works
Olsson, U., Bondjers, G., & Camejo, G. (1999) · Diabetes · doi:10.2337/diabetes.48.3.616 · Cited by 97 · see citing works
Chang, M. Y., Potter‐Perigo, S., Tsoi, C., Chait, A., & Wight, T. N. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.7.4766 · Cited by 95 · see citing works
Hollmann, J., Schmidt, A., Bassewitz, D. B. V., & Buddecke, E. (1989) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.9.2.154 · Cited by 80 · see citing works
Role of the Renin-Angiotensin-Aldosterone System in the Pathogenesis of Atherosclerosis
Durante, A., Peretto, G., Laricchia, A., Ancona, F., Spartera, M., Mangieri, A., & Cianflone, D. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212799436467 · Cited by 78 · see citing works
Wilson, P. G., Thompson, J. C., Webb, N. R., de Beer, F. C., King, V. L., & Tannock, L. R. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.080201 · Cited by 72 · see citing works
Self-citationYang, S. N. Y., Burch, M. L., Tannock, L. R., Evanko, S. P., Osman, N., & Little, P. J. (2010) · Journal of Diabetes · doi:10.1111/j.1753-0407.2010.00089.x · Cited by 62 · see citing works
Self-citationHuang, F., Thompson, J. C., Wilson, P. G., Aung, H. H., Rutledge, J. C., & Tannock, L. R. (2007) · Journal of Lipid Research · doi:10.1194/jlr.m700329-jlr200 · Cited by 60 · see citing works
Self-citationFigueroa, J. E., & Vijayagopal, P. (2002) · Atherosclerosis · doi:10.1016/s0021-9150(01)00714-6 · Cited by 53 · see citing works
Biglycan protects cardiomyocytes against hypoxia/reoxygenation injury: Role of nitric oxide
Csont, T., Görbe, A., Bereczki, E., Szunyog, A., Aypar, E., Tóth, M. E., Varga, Z. V., Csonka, C., Fülöp, F., Sántha, M., et al. (2010) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2010.01.013 · Cited by 39 · see citing works
Rodrı́guez-Lee, M., Östergren‐Lundén, G., Wallin, B., Moses, J., Bondjers, G., & Camejo, G. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000191659.94059.62 · Cited by 32 · see citing works
Tang, T., Wilson, P. G., Thompson, J. C., Nelson, C., Yoder, M. H., & Tannock, L. R. (2013) · Journal of Lipid Research · doi:10.1194/jlr.p040139 · Cited by 19 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 2
- [16]Schwenke DC Carew TE Initiation of atherosclerotic lesions in cholesterol-fed rabbits Arteriosclerosis 1989 9 908 918 2590068
- [24]Wilson PG Thompson JC Webb NR SAA, but not CRP, stimulates vascular proteoglycan synthesis in a pro-atherogenic manner Am J Pathol 2008 173 1902 1910 18974302 PMC2626400
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Yu, Y., Cai, Y., Yang, F., Yang, Y., Cui, Z., Shi, D., & Bai, R. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e37727 · Cited by 96 · see citing works
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Thompson, J. C., Jayne, C., Thompson, J., Wilson, P. G., Yoder, M. H., Webb, N. R., & Tannock, L. R. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m054015 · Cited by 89 · see citing works
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Qu, D. C., Wang, L., Huo, M., Song, W., Lau, C., Xu, J., Xu, A., Yao, X., Chiu, J., Tian, X. Y., et al. (2019) · Cardiovascular Research · doi:10.1093/cvr/cvz046 · Cited by 67 · see citing works
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Grandoch, M., Kohlmorgen, C., Melchior‐Becker, A., Feldmann, K., Homann, S., Müller, J., Kiene, L. S., Zeng-Brouwers, J., Schmitz, F., Nagy, N., et al. (2016) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.115.306973 · Cited by 47 · see citing works
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Barth, M., Selig, J. I., Klose, S., Schomakers, A., Kiene, L. S., Raschke, S., Boeken, U., Akhyari, P., Fischer, J. W., & Lichtenberg, A. (2018) · Diabetes and Vascular Disease Research · doi:10.1177/1479164118817922 · Cited by 32 · see citing works
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Urschel, K., Hug, K. P., Zuo, H., Büttner, M., Furtmair, R., Kuehn, C., Stumpfe, F. M., Botos, B., Achenbach, S. S., Yuan, Y., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411595 · Cited by 4 · see citing works
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Prochilo, G., Li, C., Miliotou, E., Nakasone, R., Pfeffer, A., Beaman, C. B., Kaneko, N., Liebeskind, D. S., & Hinman, J. D. (2024) · Translational Stroke Research · doi:10.1007/s12975-024-01310-4 · Cited by 3 · see citing works
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Hai, C.-M. (2016) · WORLD SCIENTIFIC eBooks · doi:10.1142/9789813144064_0007
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- Authors
- Thompson, J. C., Tang, T., Wilson, P. G., Yoder, M. H., & Tannock, L. R.
- Affiliations
- University of Kentucky (US)
- United States Department of Veterans Affairs (US)
- Corresponding author
- Tannock, Lisa R.
- Venue
- Atherosclerosis
- Publisher
- Elsevier BV
- Published
- 2014-07
- Volume
- 235
- Issue
- 1
- Pages
- 71-75
- ISSN
- 0021-9150 (ISSN-L)
- PMC
- PMC4054690
- OpenAlex
- W2016360431
- Cited by
- 45
- References
- 28
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 5 · 2023: 4 · 2021: 5 · 2020: 3 · 2019: 5 · 2018: 5 · 2017: 3 · 2016: 3 · 2015: 3 · 2014: 5
- FWCI
- 2.32
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Atherosclerosis (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung and Blood Institute of the National Institutes of Health (RO1HL082772, RO1HL082772-0351)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Keywords
- biglycan, LDL receptor deficiency, hyperlipidemia, Western diet, transgenic mice, lipid retention
- MeSH terms
- Actins, Animals, Blood Vessels, Disease Models, Animal, Female, Hyperlipidemias, Male, Mice, Inbred C57BL, Mice, Transgenic, Promoter Regions, Genetic, Proteoglycans, Transgenes, Atherosclerosis, Mice, Biglycan
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