Update on peripheral artery disease: Epidemiology and evidence-based facts
Open accessAbstract
Peripheral artery disease (PAD) is a progressive disorder characterized by stenosis and/or occlusion of large and medium-sized arteries, other than those that supply the heart (coronary artery disease, CAD) or the brain (cerebrovascular disease). PAD affects the lower extremities more commonly than the upper extremity vessels, and may lead to an recurrent fatigue, cramping sensation, or pain that is known as claudicatio intermittens (intermittent claudication), which is the most recognized symptomatic subset of lower extremity PAD.
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Cites
Haffner, S. M., Lehto, S., Rönnemaa, T., Pyörälä, K., & Laakso, M. (1998) · New England Journal of Medicine · doi:10.1056/nejm199807233390404 · Cited by 7,000 · see citing works
Peripheral Arterial Disease Detection, Awareness, and Treatment in Primary Care
Hirsch, A. T. (2001) · JAMA · doi:10.1001/jama.286.11.1317 · Cited by 2,835 · cited 1× · see citing works
“Examining the population enrolled in the PARTNERS (Peripheral Arterial Disease Awareness Risk and Treatment: New Resources for Survival) program [4], several important aspects related to PAD epidemiology emerge.”
BackgroundTicagrelor versus Clopidogrel in Symptomatic Peripheral Artery Disease
Hiatt, W. R., Fowkes, F. G. R., Heizer, G., Berger, J. S., Baumgartner, I., Held, P., Katona, B. G., Mahaffey, K. W., Norgren, L., Jones, W. S., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1611688 · Cited by 636 · see citing works
Peripheral arterial disease in patients with diabetes.
Marso, S., & Hiatt, W. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.09.065 · Cited by 571 · see citing works
Schramm, T. K., Gislason, G., Køber, L., Rasmussen, S., Rasmussen, J. N., Abildstrom, S. Z., Hansen, M. L., Folke, F., Buch, P., Madsen, M. M., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.720847 · Cited by 536 · see citing works
9. Cardiovascular Disease and Risk Management: Standards of Medical Care in Diabetes—2018
(2017) · Diabetes Care · doi:10.2337/dc18-s009 · Cited by 490 · see citing works
Is diabetes a coronary risk equivalent? Systematic review and meta‐analysis
Bulugahapitiya, U., Siyambalapitiya, S., Sithole, J., & IDRIS, I. R. (2008) · Diabetic Medicine · doi:10.1111/j.1464-5491.2008.02640.x · Cited by 377 · see citing works
Association Between Advanced Age and Vascular Disease in Different Arterial Territories
Savji, N., Rockman, C. R., Skolnick, A. H., Guo, Y., Adelman, M. A., Riles, T. S., & Berger, J. S. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.01.054 · Cited by 324 · see citing works
Endovascular Intervention for Peripheral Artery Disease
Thukkani, A. K., & Kinlay, S. (2015) · Circulation Research · doi:10.1161/circresaha.116.303503 · Cited by 297 · see citing works
Wannamethee, S. G., Shaper, A. G., Whincup, P. H., Lennon, L., & Sattar, N. (2011) · Archives of Internal Medicine · doi:10.1001/archinternmed.2011.2 · Cited by 281 · see citing works
Wrobel, J. S., Mayfield, J. A., & Reiber, G. E. (2001) · Diabetes Care · doi:10.2337/diacare.24.5.860 · Cited by 248 · see citing works
The toe-brachial index in the diagnosis of peripheral arterial disease
Høyer, C., Sandermann, J., & Petersen, L. J. (2013) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2013.03.044 · Cited by 236 · see citing works
Gnatiuc, L., Herrington, W. G., Halsey, J., Tuomilehto, J., Fang, X., Kim, H., Bacquer, D. D., Dobson, A. J., Criqui, M. H., Jacobs, D. R., et al. (2018) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(18)30079-2 · Cited by 225 · see citing works
Rana, J. S., Liu, J. Y., Moffet, H. H., Jaffe, M. G., & Karter, A. J. (2015) · Journal of General Internal Medicine · doi:10.1007/s11606-015-3556-3 · Cited by 151 · see citing works
Sex Differences in the Effect of Diabetes Duration on Coronary Heart Disease Mortality
Natarajan, S., Liao, Y., Sinha, D., Cao, G., McGee, D., & Lipsitz, S. R. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.4.430 · Cited by 104 · see citing works
Is heart failure more prevalent in patients with peripheral arterial disease? A meta-analysis.
Anand, R., Ventura, H., & Mehra, M. (2007) · Congestive Heart Failure · doi:10.1111/j.1527-5299.2007.07344.x · Cited by 61 · see citing works
Diabetes mellitus is a coronary heart disease risk equivalent for peripheral vascular disease
Newman, J. D., Rockman, C. R., Kosiborod, M., Guo, Y., Zhong, J., WEINTRAUB, H. S., Schwartzbard, A. Z., Adelman, M. A., & Berger, J. S. (2016) · American Heart Journal · doi:10.1016/j.ahj.2016.09.002 · Cited by 56 · see citing works
Integrating diet and inflammation to calculate cardiovascular risk
Gambardella, J., & Santulli, G. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.08.041 · Cited by 50 · see citing works
Self-citationManagement of Peripheral Arterial Disease
Steffen, L. M., Duprez, D. A., Boucher, J. L., Ershow, A. G., & Hirsch, A. T. (2008) · Diabetes Spectrum · doi:10.2337/diaspect.21.3.171 · Cited by 42 · see citing works
Peripheral vascular disease risk in diabetic individuals without coronary heart disease
Wilcox, T., Newman, J. D., Maldonado, T. S., Rockman, C. R., & Berger, J. S. (2018) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2018.04.026 · Cited by 38 · see citing works
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Racial and Ethnic Disparities in Peripheral Artery Disease
Hackler, E. L., Hamburg, N. M., & White Solaru, K. T. (2021) · Circulation Research · doi:10.1161/circresaha.121.318243 · Cited by 141 · see citing works
Supervised Exercise Therapy and Revascularization for Intermittent Claudication
Saratzis, A., Paraskevopoulos, I., Patel, S., Donati, T., Biasi, L., Diamantopoulos, A., Zayed, H., & Katsanos, K. (2019) · JACC: Cardiovascular Interventions · doi:10.1016/j.jcin.2019.02.018 · Cited by 60 · see citing works
- Authors
- Shu, J., & Santulli, G.
- Affiliations
- Albert Einstein College of Medicine (US)
- Corresponding author
- Santulli, Gaetano
- Venue
- Atherosclerosis
- Publisher
- Elsevier BV
- Published
- 2018-08
- Volume
- 275
- Pages
- 379-381
- ISSN
- 0021-9150 (ISSN-L)
- PMC
- PMC6113064
- OpenAlex
- W2803628047
- Semantic Scholar
- 15d6ca863ccf26a50cadd5dcbab5bef2d2eac97a
- Cited by
- 487
- References
- 20
- Citations by year
- 2026: 30 · 2025: 61 · 2024: 56 · 2023: 75 · 2022: 97 · 2021: 87 · 2020: 58 · 2019: 21 · 2018: 1
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Atherosclerosis (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (DK107895, DK020541)
- Topics
- Health Sciences › Medicine › Surgery › Peripheral Artery Disease Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetic Foot Ulcer Assessment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- peripheral arterial disease, intermittent claudication, lower limb arteries, diabetes mellitus, peripheral vascular disease, comorbid risk factors, epidemiology
- MeSH terms
- Coronary Disease, Humans, Peripheral Arterial Disease
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