The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Fundoplication After Lung Transplantation Prevents the Allograft Dysfunction Associated With Reflux
Open accessAbstract
Background Gastroesophageal reflux disease (GERD) in lung recipients is associated with decreased survival and attenuated allograft function. This study evaluates fundoplication in preventing GERD-related allograft dysfunction. Methods Prospectively collected data on patients who underwent transplantation between January 2001 and August 2009 were included. Lung transplant candidates underwent esophageal pH probe testing before transplantation and surveillance spirometry evaluation after transplantation. Bilateral lung transplant recipients who had pretransplant pH probe testing and posttransplant 1-year forced expiratory volume in the first second of expiration (FEV1) data were included for analysis. Results Of 297 patients who met study criteria, 222 (75%) had an abnormal pH probe study before or early after transplantation and 157 (53%) had a fundoplication performed within the first year after transplantation. Patients with total proximal acid contact times greater than 1.2% or total distal acid contact times greater than 7.0% demonstrated an absolute decrease of 9.4% (± 4.6) or 12.0% (± 5.4) in their respective mean 1-year FEV1 values. Patients with abnormal acid contact times who did not undergo fundoplication had considerably worse predicted peak and 1-year FEV1 results compared with recipients receiving fundoplication (peak percent predicted = 75% vs. 84%; p = 0.004 and 1-year percent predicted = 68% vs. 77%; p = 0.003, respectively). Conclusions Lung transplant recipients with abnormal esophageal pH studies attain a lower peak allograft function as well as a diminished 1-year FEV1 after transplantation. However a strategy of early fundoplication in these recipients appears to preserve lung allograft function.
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Anti-reflux surgery before and early after transplant has been associated with a decrease in the development of early allograft dysfunction.
“Anti-reflux surgery pre-transplant and early post-transplant has been associated with a decrease in the development of early allograft dysfunction.(34, 35)”
From Consensus document for the selection of lung transplant candidates: An update from the International Society for Heart and Lung Transplantation. (2021) · cites this paper as [35]
The Results and Conclusions (page unavailable) associate fundoplication within the first year after transplantation with better peak and 1-year allograft function in recipients with abnormal reflux testing. The Methods distinguish reflux testing before transplantation from surgery after transplantation; this study does not support the claim about pre-transplant surgery or directly establish a decrease in the development of early allograft dysfunction. (LLM, conf=0.88)
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Cites
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Self-citationBile acid aspiration and the development of bronchiolitis obliterans after lung transplantation
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Lung Transplantation Exacerbates Gastroesophageal Reflux Disease *
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Self-citationRespiratory viruses and chronic rejection in lung transplant recipients
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Self-citationInfluenza Pneumonia in Lung Transplant Recipients
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Self-citationAmbulatory Esophageal pH Monitoring
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Flagged first, then by citations
Research works printed but not linked: 1
- Young, 2003, Lung transplantation exacerbates gastroesophageal reflux disease, Chest, 124, 1689, 10.1378/chest.124.5.1689 · DOI
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Leard, L. E., Holm, A. M., Valapour, M., Glanville, A. R., Attawar, S., Aversa, M., Campos, S. V., Christon, L. M., Cypel, M., Dellgren, G., et al. (2021) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2021.07.005 · Cited by 821
“38,39 40-42 In one study, when stratified by degree of obesity, the risk of mortality was increased for patients with a BMI > 35 and not in those with BMI 30-34.9.”
BackgroundInfluentialSelf-citationCurrent views on chronic rejection after lung transplantation
Verleden, G. M., Vos, R., Vanaudenaerde, B., Dupont, L., Yserbyt, J., Van Raemdonck, D., & Verleden, S. (2015) · Transplant International · doi:10.1111/tri.12579 · Cited by 92
Lo, W.-K., Goldberg, H. J., Wee, J., Fisichella, P. M., & Chan, W. W. (2016) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-015-2983-0 · Cited by 64
Metadata
- Authors
- Hartwig, M. G., Anderson, D. J., Onaitis, M. W., Reddy, S., Snyder, L. D., Lin, S. S., & Davis, R. D.
- Affiliations
- Duke University (US)
- Duke Medical Center (US)
- Corresponding author
- Davis, R. Duane
- Venue
- The Annals of Thoracic Surgery
- Publisher
- Elsevier BV
- Published
- 2011-08
- Volume
- 92
- Issue
- 2
- Pages
- 462-469
- ISSN
- 0003-4975 (ISSN-L)
- PMC
- PMC3617490
- OpenAlex
- W2023009191
- Semantic Scholar
- e769ffc6ee649f77cd67dd7b3da48d4c8a6cce89
- Cited by
- 155
- References
- 16
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 11 · 2023: 16 · 2022: 10 · 2021: 16 · 2020: 14 · 2019: 6 · 2018: 16 · 2017: 11 · 2016: 3 · 2015: 15 · 2014: 7 · 2013: 6 · 2012: 8
- FWCI
- 6.88
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- The Annals of Thoracic Surgery (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5k23ai095357-03)
- National Institute of Allergy and Infectious Diseases (K23-AI095357)
- Topics
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Keywords
- fundoplication, lung transplantation, gastroesophageal reflux disease, allograft dysfunction, esophageal pH monitoring, FEV1, post-transplant survival, reflux prevention
- MeSH terms
- Combined Modality Therapy, Female, Forced Expiratory Volume, Gastroesophageal Reflux, Graft Rejection, Graft Survival, Humans, Male, Middle Aged, North Carolina, Patient Care Team, Postoperative Complications, Reoperation, Respiratory Insufficiency, Retrospective Studies, Spirometry, Lung Transplantation, Fundoplication, Esophageal pH Monitoring
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