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Postoperative Atrial Fibrillation Significantly Increases Mortality, Hospital Readmission, and Hospital Costs
Open accessAbstract
Background New-onset postoperative atrial fibrillation (POAF) is the most common complication following cardiac surgery. However, the magnitude of POAF on length of stay, resource utilization, and readmission rates remains an area of clinical interest. The purpose of this study was to examine the risk-adjusted impact of POAF on measures of mortality, hospital resources, and costs among multiple centers.Methods A total of 49,264 patient records from a multi-institutional Society of Thoracic Surgeons (STS) certified database for cardiac operations (2001 to 2012) were extracted and stratified by the presence of POAF (19%) versus non-POAF (81%). The influence of POAF on outcomes was assessed by hierarchic regression modeling, adjusted for calculated STS predictive risk indices.Results Mean age was 64±11 years, and median STS predicted risk of mortality for patients who developed POAF were incrementally higher (2% vs 1%, p<0.001) compared with non-POAF patients. The rate of POAF was highest among those undergoing aortic valve replacement+coronary artery bypass grafting, aortic valve, and mitral valve replacement operations. The POAF patients had a higher unadjusted incidence of mortality, morbidity, hospital readmission, longer intensive care unit (ICU) and postoperative length of stay, and higher hospital costs. After risk adjustment, POAF was associated with a twofold increase in the odds of mortality (adjusted odds ratio=2.04, p<0.001), greater hospital resource utilization, and increased costs; POAF was associated with 48 additional ICU hours (p<0.001), 3 additional hospital days (p<0.001), and $3,000 (p<0.001) and $9,000 (p<0.001) of increased ICU and total hospital-related costs, respectively.Conclusions New onset POAF is associated with increased risk-adjusted mortality, hospital costs, and readmission rates. Protocols to reduce the incidence of POAF have the potential to significantly impact patient outcomes and the delivery of high-quality, cost-effective patient care.
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“Postoperative AF is associated with an increased early stroke risk, increased morbidity, and 30-day mortality.927,951,952”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [951]
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The more you look, the more you find
Ha, A. C. T., Verma, A., Mazer, C. D., Yanagawa, B., & Verma, S. (2019) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000000591 · Cited by 5
Hawkins, R. B., Strobel, R. J., Joseph, M., Quader, M. A., Teman, N. R., Almassi, G. H., & Mehaffey, J. H. (2022) · Vessel Plus · doi:10.20517/2574-1209.2021.116 · Cited by 5
Keller, K., Hobohm, L., & Engelhardt, M. (2020) · Thrombosis Research · doi:10.1016/j.thromres.2020.10.015 · Cited by 5
Prediction of postoperative atrial fibrillation with postoperative epicardial electrograms
Rasmussen, L. F., Andreasen, J. J., Riahi, S., Lip, G. Y. H., Lundbye‐Christensen, S., Melgaard, J., & Graff, C. (2022) · Scandinavian Cardiovascular Journal · doi:10.1080/14017431.2022.2130421 · Cited by 5
“These patients have a higher morbidity and mortality than patients who do not suffer from this postoperative arrythmia [1,2].”
BackgroundJafree, E., O’Quinn, M. P., Shoureshi, P., Rose, B., Wang, L., Nguyen, N., Nguyen, T. P., Dormer, K. J., Nguyen, K. T., Das, A., et al. (2024) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2024.09.035 · Cited by 4
Abouzid, M. R., Vyas, A., Eldahtoury, S., Anwar, J., Naccour, S., Elshafei, S. M., Memon, A., Subramaniam, V., Bennett, W. M., Morin, D. P., et al. (2023) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2023.102220 · Cited by 5
Postoperative Atrial Fibrillation Is Associated With High On-Aspirin Platelet Reactivity
Kopjar, T., Petričević, M., Gašparović, H., Svetina, L., Miličić, D., & Biočina, B. (2015) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2015.05.001 · Cited by 4
“It is associated with increased riskadjusted mortality, hospital costs, and readmission rates [4] as well as late mortality [1, 2].”
BackgroundEfird, J. T., Jindal, C., Kiser, A. C., Akhter, S. A., Crane, P. B., Kypson, A. P., Sverdlov, A. L., Davies, S. W., Kindell, L. C., & Anderson, E. J. (2018) · Journal of International Medical Research · doi:10.1177/0300060518773934 · Cited by 4
“AF is a common postoperative complication following CABG surgery and is associated with increased mortality, morbidity, hospital costs, and readmission rates.(2,22) The use of PINOT is an established risk factor for POAF.”
BackgroundDemir, A. R., Çelik, Ö., Uygur, B., Somuncu, M. U., Yılmaz, E., Avcı, Y., Bayram, M., & Ertürk, M. (2021) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2020.105591 · Cited by 4
Zengin, A., Karataş, M. B., Çanga, Y., Pay, L., Eren, S., Çalık, A. N., & Güzelburç, Ö. (2022) · Irish Journal of Medical Science (1971 -) · doi:10.1007/s11845-021-02894-8 · Cited by 5
“In the past, atrial fibrillation after cardiac surgery was believed to be a benign arrhythmia presumably as a consequence of its self-limiting feature with a median duration of 48 h; however, recent studies and meta-analyses have shown a clear association between POAF and increased short-term mortality and morbidity […”
BackgroundResultInterleukin-6 Receptor Asp358 A>C Polymorphism Is Associated With Postoperative Atrial Fibrillation
Wu, F., Feng, X., Wu, Y., Yu, M., Ding, S., & Zhao, H. (2020) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2020.04.123 · Cited by 4
Khan, J., Laurikka, J. O., Järvinen, O., Khan, N., & Järvelä, K. M. (2019) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezz365 · Cited by 4
Khawar, M., Shah, S. A., Khan, A., Waseem, A., Saeed, H. E., Fatima, A., Saifullah, M., Mehdi, A. M., Qadeer, A., & Khawar, M. M. H. (2025) · World Journal of Cardiology · doi:10.4330/wjc.v17.i10.110793 · Cited by 3
Atrial Electrography for Postoperative Tachyarrhythmia Analysis in Patients
Peotter, A. M., BROWN, D., Kalscheur, M. M., & Bergen, N. H. V. (2021) · Journal of Innovations in Cardiac Rhythm Management · doi:10.19102/icrm.2021.121003 · Cited by 3
Yamamoto, N., & Onoda, K. (2023) · Surgery Today · doi:10.1007/s00595-023-02717-6 · Cited by 3
“AF itself carries a significant risk of in-hospital mortality or morbidity [15, 16], and the downstream treatments for POAF with anti-arrhythmic and anticoagulant drugs may be associated with further complications, which may increase healthcare costs [16].”
Gaudino, M. F. L., Harik, L., Redfors, B., Sandner, S. E., Alexander, J. H., Franco, A. D., Dimagli, A., Weinsaft, J. W., Perezgrovas‐Olaria, R., Soletti, G. J., et al. (2023) · European Heart Journal Open · doi:10.1093/ehjopen/oead118 · Cited by 3
Significance of isolated postoperative atrial fibrillation in thoracic aortic aneurysm repair
Chung, M., Pan, C., Hayashi, H., Kandula, V., Zhao, Y., Levine, D., Childress, P., Sutherland, L. C., Raza, S. T., Kurlansky, P. A., et al. (2024) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2023.12.023 · Cited by 3
van de Kar, M. R. D., van Brakel, T. J., Houterman, S., de Heer, L. M., Daeter, E. J., Veer, M. V. ’., van Veghel, D., Crijns, H. J. G. M., Dekker, L., & Otterspoor, L. (2025) · European Heart Journal - Quality of Care and Clinical Outcomes · doi:10.1093/ehjqcco/qcaf124 · Cited by 3
Zochios, V., Chandan, J. S., Taverner, T., Babu, A., & Singh, H. K. (2019) · Journal of the Intensive Care Society · doi:10.1177/1751143719872945 · Cited by 3
“However, due to improving perioperative cardiac care and enhanced recovery programmes, LOS is getting shorter.(4) Age has been previously demonstrated as an important factor relating to the development of POAF, with one study suggesting that individuals over the age of 72 were more than five times as likely to develop…”
BackgroundSaitoh, M., Takahashi, T., Morisawa, T., Sakuyama, A., Watanabe, H., Sakurada, K., Hanafusa, Y., Tahara, M., IWATA, K., Ochi, Y., et al. (2021) · BMJ Open · doi:10.1136/bmjopen-2021-054303 · Cited by 3
Jadhav, K. P., Pai, P. G., Nair, I. R., Krishnan, S., & Varma, P. K. (2022) · Indian Journal of Thoracic and Cardiovascular Surgery · doi:10.1007/s12055-021-01328-5 · Cited by 3
Dahl, T. S., & Lindblom, R. P. F. (2023) · Journal of Cardiothoracic Surgery · doi:10.1186/s13019-023-02140-5 · Cited by 3
McCarthy, P. M., Mehran, R., Gerdisch, M., Ramlawi, B., Lee, R. J., Ferguson, M. A., Kruse, J. T., & Whitlock, R. P. (2024) · JTCVS structural and endovascular. · doi:10.1016/j.xjse.2024.100032 · Cited by 3
The Economic Impact of Atrial Fibrillation in the US
Sieck, S. G. (2016) · Contemporary cardiology · doi:10.1007/978-3-319-31386-3_3 · Cited by 3
Jang, M. Y., Lee, J. H., Heo, M., Lim, S. K., Chung, S. R., Sung, K., Kim, W. S., & Cho, Y. H. (2023) · The Korean Journal of Thoracic and Cardiovascular Surgery · doi:10.5090/jcs.22.112 · Cited by 3
“Several studies have examined the risk factors for the occurrence of AT after cardiac surgery [22,27,28].”
BackgroundAd, N. (2016) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezw285 · Cited by 3
Pereira, M. D. P., Lima, E. G., Garzillo, C. L., Barbosa, C. T. M., Sampaio, L. P. C., Darrieux, F., & Junior, C. V. S. (2020) · Revista da Associação Médica Brasileira · doi:10.1590/1806-9282.66.11.1473 · Cited by 3
Predicting Postoperative Atrial Fibrillation: The Search Continues
Hassler, K. R., & Ramakrishna, H. (2022) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2022.06.007 · Cited by 3
Ping, L., Wang, X., Zhou, J., Wang, J., Huang, Y., & Zhang, C. (2025) · Quantitative Imaging in Medicine and Surgery · doi:10.21037/qims-24-1915 · Cited by 2
Fields, K. G., Milner, G. D. M., Ma, J., Dhiman, P., Redfern, O., Karamnov, S., He, J., Gerry, S., Alhassan, H. A., Providencia, R. A., et al. (2025) · Anesthesiology · doi:10.1097/aln.0000000000005665 · Cited by 2
Schnaubelt, S., Stajic, A., Koller, L., Hofer, F., Kazem, N., Hammer, A., Andreas, M., Laufer, G., Steinlechner, B., Richter, B., et al. (2021) · Journal of Clinical Anesthesia · doi:10.1016/j.jclinane.2021.110309 · Cited by 2
Heerman, J. R., Boydens, C., Allaert, S., Cathenis, K., Deryckere, K., & Vanoverschelde, H. (2023) · PharmacoEconomics - Open · doi:10.1007/s41669-023-00412-3 · Cited by 2
“POAF is one of the most common arrhythmias after cardiac surgery, with a substantial financial burden on the overall postoperative costs [4, 6, 7, 9].”
BackgroundNie, C., Zhu, C., Xiao, M., Wu, Z., Yang, Q., Lu, Z., Lü, T., Meng, Y., & Wang, S. (2024) · European Heart Journal - Quality of Care and Clinical Outcomes · doi:10.1093/ehjqcco/qcae101 · Cited by 2
Zhou, Z.-Q., Chen, Y.-J., & Xu, H. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1565359 · Cited by 2
Do P-Wave Indices Manifest Atrial Fibrillation after Postoperative Atrial Fibrillation?
Rau, C. P. E., Salzmann-Djufri, M., Böning, A., Rohrbach, S., & Niemann, B. (2025) · The Thoracic and Cardiovascular Surgeon · doi:10.1055/a-2616-3919 · Cited by 2
Metadata
- Authors
- LaPar, D. J., Speir, A. M., Crosby, I. K., Fonner, E., Brown, M., Rich, J. B., Quader, M., Kern, J. A., Kron, I. L., & Ailawadi, G.
- Affiliations
- University of Virginia (US)
- Inova Health System (US)
- Mary Washington Hospital (US)
- Sentara Heart Hospital (US)
- Virginia Commonwealth University Medical Center (US)
- Corresponding author
- Ailawadi, Gorav
- Venue
- The Annals of Thoracic Surgery
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 98
- Issue
- 2
- Pages
- 527-533
- ISSN
- 0003-4975 (ISSN-L)
- OpenAlex
- W2069608457
- Cited by
- 285
- References
- 23
- Citations by year
- 2026: 16 · 2025: 25 · 2024: 23 · 2023: 27 · 2022: 34 · 2021: 27 · 2020: 23 · 2019: 25 · 2018: 28 · 2017: 28 · 2016: 16 · 2015: 12 · 2014: 1
- FWCI
- 13.03
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Annals of Thoracic Surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac, Anesthesia and Surgical Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Valve Diseases and Treatments
- Keywords
- postoperative atrial fibrillation, cardiac surgery complications, mortality, hospital readmission, hospital costs, length of hospital stay, intensive care utilization, aortic valve replacement, mitral valve replacement, coronary artery bypass grafting, risk adjustment
- MeSH terms
- Aged, Atrial Fibrillation, Female, Cardiac Surgical Procedures, Humans, Male, Middle Aged, Patient Readmission, Postoperative Complications, Retrospective Studies, Hospital Costs, Risk Adjustment
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