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Cited by 20Cardiovascular Syncope and Autonomic DisordersCardiovascular and exercise physiologyHeart Rate Variability and Autonomic Control

Menstrual cycle elicits divergent forearm vascular responses to vestibular activation in humans

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Lawrence, Johnathan E., Klein, Jenna C., Carter, Jason R.·2010·Autonomic Neuroscience
DOI 10.1016/j.autneu.2009.11.002PMC PMC2844907
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Abstract

The menstrual cycle has been reported to alter mean arterial pressure (MAP), but not muscle sympathetic nerve activity (MSNA), during vestibular activation. Specifically, MAP responses to head-down rotation (HDR) are augmented during the mid-luteal (ML) phase compared to the early follicular (EF) phase in young, eumenorrheic women. The purpose of the present study was to determine if the menstrual cycle influences vestibular-mediated changes in limb blood flow. MSNA, MAP, heart rate, and limb blood flow responses to HDR were measured in 12 healthy women. Resting MSNA, MAP, heart rate, forearm blood flow and calf blood flow were not altered by the menstrual cycle. HDR elicited similar increases in MSNA during the EF (Delta3+/-1 bursts/min; P<0.05) and ML (Delta2+/-1 bursts/min; P<0.05) phase, but only increased MAP during the ML phase (Delta4+/-2 mmHg; P<0.05). HDR did not change heart rate during either the EF or ML phase. HDR elicited similar increases in calf vascular resistance during the EF (Delta6+/-2 mmHg/mL/100 mL/min; P<0.05) and ML (Delta7+/-2 mmHg/mL/100mL/min; P<0.05) phases of the menstrual cycle. In contrast, HDR increased forearm vascular resistance during the ML phase (Delta4+/-2 mmHg/mL/100mL/min; P<0.05), but not the EF phase (Delta0+/-2 mmHg/mL/100mL/min). These findings suggest an increased transduction of sympathetic nerve activity into forearm vascular resistance during the ML phase, and reveal the first recorded divergent vascular response to vestibular excitation in human limbs.

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Authors
Lawrence, J. E., Klein, J. C., & Carter, J. R.
Affiliations
Michigan Technological University (US)
ORCID
Venue
Autonomic Neuroscience
Publisher
Elsevier BV
Published
2010-04
Volume
154
Issue
1-2
Pages
89-93
ISSN
1566-0702 (ISSN-L)
DOI
10.1016/j.autneu.2009.11.002
PMC
PMC2844907
OpenAlex
W2124992974
Cited by
20
References
27
Citations by year
2025: 2 · 2022: 2 · 2021: 1 · 2017: 2 · 2014: 3 · 2012: 3
FWCI
3.37
Type
journal article
Language
en
Open access
Licence
Locations
  • Autonomic Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Digital Commons - Michigan Tech (Michigan Technological University) (submittedVersion)
Funders
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute (HL088689, R15HL088689)
Topics
  • Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Keywords
menstrual cycle, muscle sympathetic nerve activity, forearm blood flow, calf blood flow, vascular resistance, mean arterial pressure, heart rate, mid-luteal phase, early follicular phase, limb blood flow
MeSH terms
Analysis of Variance, Blood Pressure, Blood Vessels, Female, Forearm, Heart Rate, Humans, Menstrual Cycle, Peroneal Nerve, Vestibule, Labyrinth, Head-Down Tilt, Young Adult

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