Subdiaphragmatic vagotomy enhances stress-induced epinephrine release in rats
Abstract
Neuroendocrine stress response is regulated by several feedback loops. Since it has been suggested that afferent vagal pathways contribute to these feedback loops, we examined the effect of surgical subdiaphragmatic vagotomy on both baseline and stress-induced increases in plasma epinephrine, norepinephrine, and corticosterone levels in vagotomized and sham-operated Sprague Dawley rats. On either the 3rd or 14th day following vagotomy, the animals were exposed to acute immobilization stress and blood from the jugular vein was collected both before and during stress exposure. We found that vagotomy significantly enhanced immobilization-induced increases of plasma epinephrine, norepinephrine, and corticosterone levels on the 3rd day following surgery. However, on the 14th day following surgery, vagotomy enhanced only increase of plasma epinephrine levels in stressed rats. Our data indicate that afferent pathways of the vagus nerve are involved in negative feedback regulation of epinephrine secretion from the adrenal medulla during stressful conditions. We hypothesize that this feedback mechanism might be mediated by the binding of circulating epinephrine on β2-adrenergic receptors localized on sensory endings of the vagus nerve.
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In rodents, vagotomy increases plasma epinephrine concentrations at baseline and after immobilization stress.
“and increased epinephrine concentrations in plasma at baseline and after immobilization stress (Khasar et al., 2003;Mravec et al., 2015).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Mravec et al., 2015
Cites
Mechanisms of rapid glucocorticoid feedback inhibition of the hypothalamic–pituitary–adrenal axis
Tasker, J. G., & Herman, J. P. (2011) · Stress · doi:10.3109/10253890.2011.586446 · Cited by 277 · see citing works
Neural Regulation of the Stress Response: The Many Faces of Feedback
Myers, B., McKlveen, J. M., & Herman, J. P. (2012) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-012-9801-y · Cited by 175 · cited 1× · see citing works
“For example, glucocorticoids have been found to exert a direct, inhibitory influence on the activity of the hypothalamic–pituitary–adrenal (HPA) axis at the level of the central nervous system (Myers et al., 2012; Tasker et al., 2011).”
BackgroundO’Keane, V., Dinan, T. G., Scott, L., & Corcoran, C. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.049 · Cited by 111 · see citing works
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Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · see citing works
Microbiota alteration is associated with the development of stress-induced despair behavior
Marin, I. A., Goertz, J. E., Ren, T., Rich, S. S., Onengut-Gumuscu, S., Farber, E., Wu, M., Overall, C. C., Kipnis, J., & Gaultier, A. (2017) · Scientific Reports · doi:10.1038/srep43859 · Cited by 369 · see citing works
- Authors
- Mravec, B., Ondicova, K., Tillinger, A., & Pecenak, J.
- Affiliations
- Slovak Academy of Sciences (SK)
- Venue
- Autonomic Neuroscience
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 190
- Pages
- 20-25
- ISSN
- 1566-0702 (ISSN-L)
- OpenAlex
- W2081775897
- Cited by
- 19
- References
- 3
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 2 · 2017: 4
- FWCI
- 0.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Autonomic Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- VEGA (2/0028/14, 1/0300/15)
- APVV (0007/10)
- Topics
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- subdiaphragmatic vagotomy, neuroendocrine stress response, restraint stress, norepinephrine, corticosterone, adrenal medulla, negative feedback regulation, beta2-adrenergic receptor, sensory nerve endings, plasma catecholamines
- MeSH terms
- Animals, Body Weight, Corticosterone, Epinephrine, Hypothalamo-Hypophyseal System, Male, Norepinephrine, Pituitary-Adrenal System, Random Allocation, Restraint, Physical, Stress, Psychological, Time Factors, Vagotomy, Vagus Nerve, Rats, Sprague-Dawley, Feedback, Physiological
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