Role of endogenous retroviruses in murine SLE
Open accessAbstract
Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by B cell hyperactivity leading to the production of various autoantibodies and subsequent development of glomerulonephritis, i.e. lupus nephritis. Among the principal targets of the autoantibodies produced in murine SLE are nucleic acid-protein complexes and the envelope glycoprotein gp70 of endogenous retroviruses. Recent studies have revealed that the innate receptor TLR7 plays a pivotal role in the development of a wide variety of autoimmune responses against DNA- and RNA-containing nuclear antigens, while TLR9 rather plays a protective role. In addition, the regulation of autoimmune responses against endogenous retroviral gp70 by TLR7 suggests the implication of endogenous retroviruses in this autoimmune response. Moreover, the demonstration that TLR7 is involved in the acute phase expression of serum gp70 uncovers an additional pathogenic role of TLR7 in murine lupus nephritis by promoting the expression of nephritogenic gp70 autoantigen. Clearly, the eventual identification of endogenous retroviruses implicated in murine SLE and of mouse genes regulating their production could provide a clue for the potential role of endogenous retroviruses in human SLE.
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A significant amount of work has incriminated the envelope glycoprotein of certain endogenous MLVs as an autoantigen in murine SLE.
“A significant amount of work has incriminated the envelope glycoprotein of certain endogenous MLVs as an autoantigen in murine SLE 42.”
From Are human endogenous retroviruses pathogenic? An approach to testing the hypothesis (2013) · cites this paper as [42]
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Heikenwalder, M., Polymenidou, M., Junt, T., Sigurdson, C., Wagner, H., Akira, S., Zinkernagel, R., & Aguzzi, A. (2004) · Nature Medicine · doi:10.1038/nm987 · Cited by 449 · see citing works
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Are human endogenous retroviruses pathogenic? An approach to testing the hypothesis
Young, G. R., Stoye, J. P., & Kassiotis, G. (2013) · BioEssays · doi:10.1002/bies.201300049 · Cited by 78 · see citing works
“Although the identity of human REs or HERVs whose replication intermediates might accumulate in cells deficient in TREX1, or indeed their potential to trigger pathogenic production of IFNs, has not been confirmed, it is speculated that similar accumulation of replication intermediates of endogenous REs in the absence…”
BackgroundInfluentialYoung, G. R., Ploquin, M. J.-Y., Eksmond, U., Wadwa, M., Stoye, J. P., & Kassiotis, G. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002709 · Cited by 56 · see citing works
- Authors
- Baudino, L., Yoshinobu, K., Morito, N., Santiago-Raber, M.-L., & Izui, S.
- Affiliations
- University of Geneva (CH)
- Corresponding author
- Izui, Shozo
- ORCID
- Morito, Naoki
- Venue
- Autoimmunity Reviews
- Publisher
- Elsevier BV
- Published
- 2010-11
- Volume
- 10
- Issue
- 1
- Pages
- 27-34
- ISSN
- 1568-9972 (ISSN-L)
- OpenAlex
- W2053754255
- Cited by
- 54
- References
- 1
- Citations by year
- 2025: 3 · 2024: 4 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 2 · 2016: 4 · 2015: 3 · 2014: 4 · 2013: 9 · 2012: 5
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Autoimmunity Reviews (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion)
- Funders
- Lupus Research Alliance
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- endogenous retroviruses, systemic lupus erythematosus, lupus nephritis, TLR7, TLR9, autoantibodies, protein-nucleic acid complexes, B cell hyperactivity, innate immunity, autoimmunity, mouse model
- MeSH terms
- Animals, Humans, Lupus Erythematosus, Systemic, Viral Envelope Proteins, Endogenous Retroviruses, Toll-Like Receptor 7, Mice
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