The DOI matches its Crossref record; 110 of the 110 references it cites were found in a registry or an index.
Vimentin as antigenic target in autoimmunity: A comprehensive review
Abstract
Vimentin is a protein of intermediate filament family, which is expressed in all mesenchymal cells. Vimentin plays a key role in the physiology of the cell, cellular interactions and the functioning of the immune system. Post-translationally modified and native forms of vimentin are involved in the pathogenesis of inflammation and many autoimmune diseases: rheumatoid arthritis, sarcoidosis, systemic lupus erythematosus, antiphospholipid syndrome, Crohn's disease, ankylosing spondyloarthritis and idiopathic pulmonary fibrosis. Modifications of the protein lead to the formation of antigenic epitopes and, as a result, to the synthesis of antibodies. Citrullinated, carbamylated and acetylated forms of vimentin participate in the pathogenesis of RA, and antibodies against them serve as diagnostic and prognostic markers of the disease. Epitopes of native vimentin are antigenic in the group of HLA-DRB1*0301 positive patients with sarcoidosis. In addition, vimentin takes part in pathogenesis of tubulointerstitial inflammation and glomerulonephritis in lupus. In antiphospholipid syndrome interactions of vimentin and cardiolipin on the surface of apoptotic cells lead to the formation of an immunogenic complex. Antibodies against vimentin/cardiolipin complex are involved in the mechanism of thrombogenesis and serve to identify patients seronegative for antibodies to cardiolipin and ß2glycoprotein-I with the clinical features. Post-translationally modified form of the protein is citrullinated and MMP-degraded vimentin, which was found in serum of patients with Crohn's disease and ankylosing spondyloarthritis.
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“Retention of some of these cellular proteins, such as vimentin, which has inherent antigenicity, may contribute to decellularized tissues’ immunogenicity [59].”
From Immunogenicity of decellularized extracellular matrix scaffolds: a bottleneck in tissue engineering and regenerative medicine (2023) · cites this paper as [59]
In the citing paper
“Additionally, ECM alterations may turn it into a source of immunogenicity in decellularized tissues [59].”
From Immunogenicity of decellularized extracellular matrix scaffolds: a bottleneck in tissue engineering and regenerative medicine (2023) · cites this paper as [59]
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Braun, A., Mobbs, J. I., Chung, S., Tuomisto, J. E. E., Li, C., Scull, K. E., Ayala, R., Anand, S., Ramarathinam, S. H., Kern, J. S., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.01.651638
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Machine learning–driven decoding of maternal immune signatures in repeated pregnancy loss
Ko, T. L., Park, J., Leem, D., Kim, J., Han, J. W., Park, J. S., Lee, S. K., & Paik, H. (2026) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1014806
Metadata
- Authors
- Musaelyan, A., Lapin, S., Nazarov, V., Tkachenko, O., Gilburd, B., Mazing, A., Mikhailova, L., & Shoenfeld, Y.
- Affiliations
- First Pavlov State Medical University of St. Petersburg (RU)
- Tel Aviv University (IL)
- St Petersburg University (RU)
- Corresponding author
- Lapin, Sergey
- Venue
- Autoimmunity Reviews
- Publisher
- Elsevier BV
- Published
- 2018-09
- Volume
- 17
- Issue
- 9
- Pages
- 926-934
- ISSN
- 1568-9972 (ISSN-L)
- OpenAlex
- W2883842005
- Cited by
- 111
- References
- 110
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 16 · 2023: 12 · 2022: 18 · 2021: 12 · 2020: 26 · 2019: 12 · 2018: 1
- FWCI
- 2.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Autoimmunity Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Government of the Russian Federation (14.W03.31.0009)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Health Sciences › Medicine › Rheumatology › Systemic Sclerosis and Related Diseases
- Keywords
- vimentin, autoimmunity, intermediate filaments, citrullinated vimentin, post-translational modification, rheumatoid arthritis, sarcoidosis, systemic lupus erythematosus, antiphospholipid syndrome, Crohn's disease, idiopathic pulmonary fibrosis, HLA-DRB1*0301, cardiolipin, thrombus formation, autoantibodies, antigenic determinants, tubulointerstitial inflammation, glomerulonephritis
- MeSH terms
- Arthritis, Rheumatoid, Humans, Lupus Erythematosus, Systemic, Protein Processing, Post-Translational, Vimentin, Autoimmunity
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