The DOI matches its Crossref record; 122 of the 122 references it cites were found in a registry or an index.
Hashimoto's thyroiditis: An update on pathogenic mechanisms, diagnostic protocols, therapeutic strategies, and potential malignant transformation
Abstract
Hashimoto's thyroiditis, characterized by thyroid-specific autoantibodies, is one of the commonest autoimmune disorders. Although the exact etiology has not been fully elucidated, Hashimoto's thyroiditis is related to an interaction among genetic elements, environmental factors and epigenetic influences. Cellular and humoral immunity play a key role in the development of the disease; thus, a T and B cells inflammatory infiltration is frequently found. Histopathologic feature of the disease includes lymphoplasmacytic infiltration, lymphoid follicle formation with germinal centers, and parenchymal atrophy. Moreover, the occurrence of large follicular cells and oxyphilic or Askanazy cells is frequently associated to Hashimoto's thyroiditis. Clinically, Hashimoto's thyroiditis is characterized mainly by systemic manifestations due to the damage of the thyroid gland, developing a primary hypothyroidism. Diagnosis of Hashimoto's thyroiditis is clinical and based on clinical characteristics, positivity to serum antibodies against thyroid antigens (thyroid peroxidase and thyroglobulin), and lymphocytic infiltration on cytological examination. The mainstream of treatment is based on the management of the hypothyroidism with a substitution therapy. A relationship between Hashimoto's thyroiditis and a possible malignant transformation has been proposed in several studies and involves immunological/hormonal pathogenic links although specific correlation is still debated and needs to be further investigated with prospective studies.
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Citations
Cites
High Serum IgG4 Concentrations in Patients with Sclerosing Pancreatitis
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Epigenetics and the environment: emerging patterns and implications
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Hashimoto thyroiditis: Clinical and diagnostic criteria
Caturegli, P., De Remigis, A., & Rose, N. R. (2014) · Autoimmunity Reviews · doi:10.1016/j.autrev.2014.01.007 · Cited by 1,057
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Hashimotos' thyroiditis: epidemiology, pathogenesis, clinic and therapy
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The incidence and prevalence of thyroid autoimmunity
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Cited by
NIBAN1, Exploring its Roles in Cell Survival Under Stress Context
Diana, P., & Carvalheira, G. M. G. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.867003 · Cited by 26
Gambineri, A., Scarano, E., Rucci, P., Perri, A., Tamburrino, F., Altieri, P., Corzani, F., Cecchetti, C., Dionese, P., Belardinelli, E., et al. (2022) · Journal of Endocrinological Investigation · doi:10.1007/s40618-022-01853-z · Cited by 18
“Diagnosis of Hashimoto’s thyroiditis (HT) was made if antibodies anti-thyroperoxidase (TPO) and/or anti-thyroglobulin were detected in serum [27], whereas a diagnosis of Graves' disease was made in the presence of hyperthyroidism with TSH-receptor antibodies (TRAb) in the circulation [28].”
Result
Metadata
- Authors
- Ralli, M., Angeletti, D., Fiore, M., D'Aguanno, V., Lambiase, A., Artico, M., de Vincentiis, M., & Greco, A.
- Venue
- Autoimmunity Reviews
- Publisher
- Elsevier BV
- Published
- 2020-10
- Volume
- 19
- Issue
- 10
- Pages
- 102649
- ISSN
- 1568-9972 (ISSN-L)
- OpenAlex
- W3049036765
- Cited by
- 600
- References
- 122
- FWCI
- 33.75
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Ralli, M., Angeletti, D., Fiore, M., D'Aguanno, V., Lambiase, A., Artico, M., de Vincentiis, M., & Greco, A. (2020). Hashimoto's thyroiditis: An update on pathogenic mechanisms, diagnostic protocols, therapeutic strategies, and potential malignant transformation. Autoimmunity Reviews. https://doi.org/10.1016/j.autrev.2020.102649
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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