Myocarditis in systemic immune-mediated diseases: Prevalence, characteristics and prognosis. A systematic review
Abstract
Many systemic immune-mediated diseases (SIDs) may involve the heart and present as myocarditis with different histopathological pictures, i.e. lymphocytic, eosinophilic, granulomatous, and clinical features, ranging from a completely asymptomatic patient to life-threatening cardiogenic shock or arrhythmias. Myocarditis can be part of some SIDs, such as sarcoidosis, systemic lupus erythematosus, systemic sclerosis, antiphospholipid syndrome, dermato-polymyositis, eosinophilic granulomatosis with polyangiitis and other vasculitis syndromes, but also of some organ-based immune-mediated diseases with systemic expression, such as chronic inflammatory bowel diseases. The aim of this review is to describe the prevalence, main clinical characteristics and prognosis of myocarditis associated with SIDs.
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Sarcoidosis is a systemic autoimmune syndrome characterized by nonnecrotizing granulomas in various organs including the lung and heart.
“Sarcoidosis is a systemic autoimmune syndrome characterized by the formation of nonnecrotizing granulomas, a histological hallmark, found in various organs including the lung and heart.”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [210]
Cites
PRISMA-P Group, Moher, D., Shamseer, L., Clarke, M., Ghersi, D., Liberati, A., Petticrew, M., Shekelle, P., & Stewart, L. A. (2015) · Systematic Reviews · doi:10.1186/2046-4053-4-1 · Cited by 26,223 · see citing works
Cervera, R., Piette, J., Font, J., Khamashta, M. A., Shoenfeld, Y., Camps, M. T., Jacobsen, S., Lakos, G., Tincani, A., Kontopoulou‐Griva, I., et al. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10187 · Cited by 2,156 · see citing works
Cardiac Autoimmunity: Myocarditis
Bracamonte-Baran, W., & Čiháková, D. (2017) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-57613-8_10 · Cited by 228 · see citing works
Caforio, A. L. P., Baritussio, A., Marcolongo, R., Cheng, C.-Y., Pontara, E., Bison, E., Cattini, M. G., Gallo, N., Plebani, M., Iliceto, S., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10112476 · Cited by 22 · see citing works
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Autoimmune Myocarditis, Old Dogs and New Tricks.
Won, T., Song, E. J., Kalinoski, H. M., Moslehi, J. J., & Čiháková, D. (2024) · Circulation Research · doi:10.1161/circresaha.124.323816 · Cited by 51 · see citing works
- Authors
- Cheng, C.-Y., Baritussio, A., Giordani, A. S., Iliceto, S., Marcolongo, R., & Caforio, A. L. P.
- Affiliations
- University of Padua (IT)
- Corresponding author
- Caforio, Alida L.P.
- ORCID
- Venue
- Autoimmunity Reviews
- Publisher
- Elsevier BV
- Published
- 2022-04
- Volume
- 21
- Issue
- 4
- Pages
- 103037
- ISSN
- 1568-9972 (ISSN-L)
- OpenAlex
- W4205498244
- Cited by
- 56
- References
- 4
- Citations by year
- 2026: 12 · 2025: 14 · 2024: 14 · 2023: 12 · 2022: 4
- FWCI
- 2.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Autoimmunity Reviews (publishedVersion)
- PubMed (publishedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Funders
- Universita degli Studi di Padova
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Vasculitis and related conditions
- Health Sciences › Medicine › Epidemiology › Inflammatory Myopathies and Dermatomyositis
- Keywords
- myocarditis, sarcoidosis, systemic lupus erythematosus, systemic sclerosis, antiphospholipid syndrome, dermatomyositis, eosinophilic granulomatosis with polyangiitis, vasculitis, inflammatory bowel disease, cardiogenic shock, cardiac arrhythmias, prognosis, prevalence, histopathology
- MeSH terms
- Humans, Myocarditis, Prognosis, Granulomatosis with Polyangiitis, Churg-Strauss Syndrome, Prevalence
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