Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients
Open accessAbstract
OBJECTIVE: To analyze the clinical and immunologic manifestations of antiphospholipid syndrome (APS) in a large cohort of patients and to define patterns of disease expression. METHODS: The clinical and serologic features of APS (Sapporo preliminary criteria) in 1,000 patients from 13 European countries were analyzed using a computerized database. RESULTS: The cohort consisted of 820 female patients (82.0%) and 180 male patients (18.0%) with a mean +/- SD age of 42 +/- 14 years at study entry. "Primary" APS was present in 53.1% of the patients; APS was associated with systemic lupus erythematosus (SLE) in 36.2%, with lupus-like syndrome in 5.0%, and with other diseases in 5.9%. A variety of thrombotic manifestations affecting the majority of organs were recorded. A catastrophic APS occurred in 0.8% of the patients. Patients with APS associated with SLE had more episodes of arthritis and livedo reticularis, and more frequently exhibited thrombocytopenia and leukopenia. Female patients had a higher frequency of arthritis, livedo reticularis, and migraine. Male patients had a higher frequency of myocardial infarction, epilepsy, and arterial thrombosis in the lower legs and feet. In 28 patients (2.8%), disease onset occurred before age 15; these patients had more episodes of chorea and jugular vein thrombosis than the remaining patients. In 127 patients (12.7%), disease onset occurred after age 50; most of these patients were men. These patients had a higher frequency of stroke and angina pectoris, but a lower frequency of livedo reticularis, than the remaining patients. CONCLUSION: APS may affect any organ of the body and display a broad spectrum of manifestations. An association with SLE, the patient's sex, and the patient's age at disease onset can modify the disease expression and define specific subsets of APS.
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The present cohort had more men (29% vs 18%) and more primary APS cases (62% vs 53%) than Cervera et al.
“We had more male patients (29% vs. 18%) and primary APS cases (62% vs. 53%).”
From Clinical course of high‐risk patients diagnosed with antiphospholipid syndrome (2010) · cites this paper as [25]
Fewer than half of Cervera et al.'s patients were LA positive.
“Less than half of the patients reported by Cervera et al. were LA positive.”
From Clinical course of high‐risk patients diagnosed with antiphospholipid syndrome (2010) · cites this paper as [25]
The present cohort differed from the Cervera et al. cohort in several respects.
“This selected cohort of patients differed from the large cohort described by Cervera et al. [25,26] in several aspects.”
From Clinical course of high‐risk patients diagnosed with antiphospholipid syndrome (2010) · cites this paper as [25]
When only primary APS patients are considered, the present data resemble Cervera et al.'s (female/male ratio 3.5:1).
“Our data come close to the data from Cervera et al., if we only considered primary APS patients (female/male ratio drops to 3.5:1) [25].”
From Clinical course of high‐risk patients diagnosed with antiphospholipid syndrome (2010) · cites this paper as [25]
Recurrences are the most common cause of death in APS.
“These recurrences not only influence morbidity but are also the most common cause of death in APS [25].”
From Clinical course of high‐risk patients diagnosed with antiphospholipid syndrome (2010) · cites this paper as [25]
Cites
Arnett, F. C., Edworthy, S. M., Bloch, D. A., McShane, D. J., Fries, J. F., Cooper, N. S., Healey, L. A., Kaplan, S. R., Liang, M. H., Luthra, H. S., et al. (1988) · Arthritis & Rheumatism · doi:10.1002/art.1780310302 · Cited by 19,753 · see citing works
The 1982 revised criteria for the classification of systemic lupus erythematosus
Tan, E. M., Cohen, A. S., Fries, J. F., Masi, A. T., Mcshane, D. J., Rothfield, N. F., Schaller, J. G., Talal, N., & Winchester, R. J. (1982) · Arthritis & Rheumatism · doi:10.1002/art.1780251101 · Cited by 14,519 · see citing works
Revised Criteria for the Classification of Rheumatoid Arthritis
Arnett, F. C. (1990) · Orthopaedic Nursing · doi:10.1097/00006416-199003000-00011 · Cited by 7,736 · see citing works
Polymyositis and Dermatomyositis
Bohan, A., & Peter, J. B. (1975) · New England Journal of Medicine · doi:10.1056/nejm197502132920706 · Cited by 5,085 · see citing works
Preliminary criteria for the classification of systemic sclerosis (scleroderma)
Masi, A. T. (1980) · Arthritis & Rheumatism · doi:10.1002/art.1780230510 · Cited by 4,925 · see citing works
Sorge, F., Simone, R. D., Marano, E., Nolano, M., Orefice, G., & Carrieri, P. B. (1988) · Cephalalgia · doi:10.1046/j.1468-2982.1988.0801001.x · Cited by 3,464 · see citing works
The management of thrombosis in the antiphospholipid-antibody syndrome
Khamashta, M. A., Cuadrado, M. J., Mujic, F., Taub, N. A., Hunt, B. J., & Hughes, G. R. V. (1995) · New England Journal of Medicine · doi:10.1056/nejm199504133321504 · Cited by 1,450 · see citing works
Vitali, C., Bombardieri, S., Moutsopoulos, H. Μ., Balestrieri, G., Bencivelli, W., Bernstein, R. M., Bjerrum, K. B., Braga, S., Coll, J., Vita, S. D., et al. (1993) · Arthritis & Rheumatism · doi:10.1002/art.1780360309 · Cited by 1,430 · see citing works
Brandt, J. T., Triplett, D. A., Alving, B. M., & Scharrer, I. (1995) · PubMed · Cited by 1,164 · see citing works
Rai, R., Cohen, H., Dave, M., & Regan, L. (1997) · BMJ · doi:10.1136/bmj.314.7076.253 · Cited by 1,113 · see citing works
Brandt, J. T., Triplett, D. A., Alving, B., & Scharrer, I. (1995) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1649901 · Cited by 993 · see citing works
Cervera, R., Khamashta, M. A., Font, J., Sebastiani, G. D., GIL, A., Lavilla, P., Domenech, I., Aydintug, A., Jędryka-Góral, A., de Ramón, E., et al. (1993) · Medicine · doi:10.1097/00005792-199303000-00005 · Cited by 976 · see citing works
The “Primary” Antiphospholipid Syndrome
Asherson, R. A., Khamashta, M. A., Ordi, J., Derksen, R. H. W. M., Machin, S. J., Barquinero, J., OUTT, H. H., Harris, E. N., Vilardell, M., & Hughes, G. R. V. (1989) · Medicine · doi:10.1097/00005792-198911000-00004 · Cited by 963 · see citing works
The "primary" antiphospholipid syndrome: major clinical and serological features.
Asherson, R. A., Khamashta, M. A., Ordi‐Ros, J., Derksen, R. H. W. M., Machin, S. J., Barquinero, J., OUTT, H. H., Harris, E. N., Vilardell, M., & Hughes, G. R. V. (1989) · PubMed · Cited by 892 · see citing works
Harris, E. N., Gharavi, A. E., Patel, S., & Hughes, G. R. (1987) · PubMed Central · Cited by 724 · see citing works
Hunder, G. G., Arend, W. P., Bloch, D. A., Calabrese, L. H., Fauci, A. S., Fries, J. F., Leavitt, R. Y., Lie, J. T., Lightfoot, R. W., Masi, A. T., et al. (1990) · Arthritis & Rheumatism · doi:10.1002/art.1780330802 · Cited by 686 · see citing works
Alarcón-Segovia, D., Delezé, M., Oria, C. V., Sánchez‐Guerrero, J., Gómez-Pacheco, L., Cabiedes, J., Fernández, L. A. N., & de León, S. P. (1989) · Medicine · doi:10.1097/00005792-198911000-00003 · Cited by 635 · see citing works
The American College of Rheumatology 1990 criteria for the classification of vasculitis: Summary
Fries, J. F., Hunder, G. G., Bloch, D. A., Michel, B. A., Arend, W. P., Calabrese, L. H., Fauci, A. S., Leavitt, R. Y., Lie, J. T., Lightfoot, R. W., et al. (1990) · Arthritis & Rheumatism · doi:10.1002/art.1780330812 · Cited by 588 · see citing works
Thrombosis, Recurrent Fetal Loss, and Thrombocytopenia
Harris, E. N. (1986) · Archives of Internal Medicine · doi:10.1001/archinte.1986.00360230069012 · Cited by 546 · see citing works
Catastrophic Antiphospholipid Syndrome: Clinical and Laboratory Features of 50 Patients
Asherson, R. A., Cervera, R., Pietté, J. C., Font, J., Lie, J. T., Burcoglu-O'Ral, A., Lim, K., Muñoz, F. J., Levy, R. A., Boué, F., et al. (1998) · Medicine · doi:10.1097/00005792-199805000-00005 · Cited by 540 · see citing works
The Catastrophic Antiphospholipid Syndrome
Rodríguez‐Pintó, I., Espinosa, G., & Cervera, R. (2014) · Rare diseases of the immune system · doi:10.1007/978-3-319-11044-8_20 · Cited by 493 · see citing works
Vianna, J. L., Khamashta, M. A., Ordi, J., Font, J. A., Cervera, R., López‐Soto, A., Tolosa, C., Franz, J. K., Selva-O’Callaghan, A., Ingelmo, M., et al. (1994) · The American Journal of Medicine · doi:10.1016/0002-9343(94)90108-2 · Cited by 466 · see citing works
(1992) · PubMed · Cited by 434 · see citing works
Friedman, A. P., Finley, K. H., Graham, J. R., Kunkle, E. C., Ostfeld, A. M., & Wolff, H. G. (1962) · Neurology · doi:10.1212/wnl.12.5.378 · Cited by 358 · see citing works
Mackworth-Young, C. G., Loizou, S., & Walport, M. J. (1989) · Annals of the Rheumatic Diseases · doi:10.1136/ard.48.5.362 · Cited by 247 · see citing works
Cervera, R., Khamashta, M. A., Font, J., Reyes, P. A., Vianna, J. L., López‐Soto, A., Amigo, M., Asherson, R. A., Azqueta, M., Paré, C., et al. (1991) · Lupus · doi:10.1177/096120339100100108 · Cited by 125 · see citing works
Cervera, R., Font, J., López‐Soto, A., Casals, F. J., Pallarés, L., Bové, A., Ingelmo, M., & Urbano-Márquez, A. (1990) · Annals of the Rheumatic Diseases · doi:10.1136/ard.49.2.109 · Cited by 115 · see citing works
Clinical study and follow-up of 100 patients withthe antiphospholipid syndrome
Muñoz-Rodríguez, F. J., Font, J., Cervera, R., Reverter, J. C., Tàssies, D., Espinosa, G., López-Soto, A., Carmona, F., Balasch, J., Ordinas, A., et al. (1999) · Seminars in Arthritis and Rheumatism · doi:10.1016/s0049-0172(99)80029-8 · Cited by 114 · see citing works
Balasch, J., Carmona, F., López‐Soto, A., Font, J. A., Creus, M. T., Fábregues, F., Ingelmo, M., & Vanrell, J. A. (1993) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a138009 · Cited by 89 · see citing works
Font, J., Loapez-Soto, A., Cervera, R., Balasch, J., Pallarés, L., Navarro, M., Bosch, X., & Ingelmo, M. (1991) · Autoimmunity · doi:10.3109/08916939108997126 · Cited by 86 · see citing works
Catastrophic antiphospholipid syndrome
Asherson, R. A., & Cervera, R. (2003) · Current Rheumatology Reports · doi:10.1007/s11926-003-0031-7 · Cited by 60 · see citing works
Francès, C., Pietté, J. C., Saada, V., Papo, T., Wechsler, B., Chosidow, O., & Godeau, P. (1994) · Lupus · doi:10.1177/096120339400300212 · Cited by 52 · see citing works
Edelman, P. (1995) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/00001703-199512000-00004 · Cited by 36 · see citing works
‘Equivocal’ Antiphospholipid Syndrome
Harris, E. N., & Pierangeli, S. S. (2000) · Journal of Autoimmunity · doi:10.1006/jaut.2000.0419 · Cited by 35 · see citing works
(2011) · SpringerReference · doi:10.1007/springerreference_37528 · Cited by 32 · see citing works
How to treat women with antiphospholipid antibodies in pregnancy?
Derksen, R. H. W. M., de Groot, P. G., Nieuwenhuis, H. K., & Christiaens, G. C. M. L. (2001) · Annals of the Rheumatic Diseases · doi:10.1136/ard.60.1.1 · Cited by 31 · see citing works
Kidney Involvement in the Antiphospholipid Syndrome
Nochy, D., Daugas, É., Huong, D. U. L. T., Pietté, J. C., & Hill, G. S. (2000) · Journal of Autoimmunity · doi:10.1006/jaut.2000.0423 · Cited by 16 · see citing works
Pediatric and Familial Antiphospholipid Syndromes
Sammaritano, L. R., & Pietté, J. C. (2002) · Elsevier eBooks · doi:10.1016/b978-044450987-1/50030-9 · Cited by 6 · see citing works
Gravellese (2000) · Pure Amsterdam UMC · doi:10.1002/1529-0131(200002)43:2 · Cited by 2 · see citing works
Wilson (1999) · doi:10.1002/1529-0131(199907)42:7
Flagged first, then by citations
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MIYAKIS, S., LOCKSHIN, M. D., ATSUMI, T., BRANCH, D. W., BREY, R. L., CERVERA, R., DERKSEN, R. H. W. M., DE GROOT, P. G., KOIKE, T., MERONI, P. L., et al. (2006) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2006.01753.x · Cited by 7,203 · see citing works
Self-citationKleindorfer, D. O., Towfighi, A., Chaturvedi, S., Cockroft, K. M., Gutierrez, J., Lombardi-Hill, D., Kamel, H., Kernan, W. N., Kittner, S. J., Leira, E. C., et al. (2021) · Stroke · doi:10.1161/str.0000000000000375 · Cited by 3,237 · see citing works
D’Cruz, D. P., Khamashta, M. A., & Hughes, G. R. V. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60279-7 · Cited by 999 · see citing works
Cervera, R., Serrano, R., Pons-Estel, G. J., Ceberio-Hualde, L., Shoenfeld, Y., de Ramón, E., Buonaiuto, V, Jacobsen, S., Zeher, M. M., Tarr, T., et al. (2015) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2013-204838 · Cited by 974 · see citing works
“To describe the course of the disease in patients with APS, we started in 1999 a multicentre observational study of 1000 European patients with a mean age of 42 years. The clinical and immunological characteristics of these patients when entered in the study have been previously reported.”
BackgroundAndréoli, L., Bertsias, G. K., Agmon‐Levin, N., Brown, S., Cervera, R., Costedoat-Chalumeau, N., Doria, A., Fischer‐Betz, R., Förger, F., Moraes‐Fontes, M. F., et al. (2016) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2016-209770 · Cited by 946 · see citing works
Asherson, R. A., Cervera, R., de Groot, P. G., Erkan, D., Boffa, M., Pietté, J. C., Khamashta, M. A., Shoenfeld, Y., & Catastrophic Antiphospholipid Syndrome Registry Project Group (2003) · Lupus · doi:10.1191/0961203303lu394oa · Cited by 863 · see citing works
Ruiz‐Irastorza, G., Crowther, M. A., Branch, W. D., & Khamashta, M. A. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60709-x · Cited by 864 · see citing works
Guidelines on the investigation and management of antiphospholipid syndrome
Keeling, D., Mackie, I., Moore, G. W., Greer, I. A., Greaves, M., & British Committee for Standards in Haematology (2012) · British Journal of Haematology · doi:10.1111/j.1365-2141.2012.09037.x · Cited by 740 · see citing works
The Pathogenesis of the Antiphospholipid Syndrome
Giannakopoulos, B., & Krilis, S. A. (2013) · New England Journal of Medicine · doi:10.1056/nejmra1112830 · Cited by 682 · see citing works
Clinical course of high‐risk patients diagnosed with antiphospholipid syndrome
PENGO, V., RUFFATTI, A., LEGNANI, C., GRESELE, P., BARCELLONA, D., ERBA, N., TESTA, S., MARONGIU, F., BISON, E., DENAS, G., et al. (2010) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2009.03674.x · Cited by 633 · see citing works
Ruiz-Irastorza, G., Cuadrado, M., Ruiz-Arruza, I., Brey, R., Crowther, M., Derksen, R., Erkan, D., Krilis, S., Machin, S., Pengo, V, et al. (2011) · Lupus · doi:10.1177/0961203310395803 · Cited by 506 · see citing works
The Catastrophic Antiphospholipid Syndrome
Rodríguez‐Pintó, I., Espinosa, G., & Cervera, R. (2014) · Rare diseases of the immune system · doi:10.1007/978-3-319-11044-8_20 · Cited by 493 · see citing works
“The catastrophic APS (CAPS) is a rare disease that affects around 1 % (0.4-1.6 %) of patients with APS [ 2 ] but is associated with a high rate of mortality [ 3 ] .”
BackgroundInfluentialUpdated assessment of the prevalence, spectrum and case definition of autoimmune disease
Hayter, S. M., & Cook, M. (2012) · Autoimmunity Reviews · doi:10.1016/j.autrev.2012.02.001 · Cited by 464 · see citing works
Management of Antiphospholipid Antibody Syndrome
Lim, W., Crowther, M. A., & Eikelboom, J. W. (2006) · JAMA · doi:10.1001/jama.295.9.1050 · Cited by 440 · see citing works
“Estimates of bleeding risk are derived from studies evaluating anticoagulant therapy in patients with APS.”
BackgroundInfluentialUrbanus, R. T., Siegerink, B., Roest, M., Rosendaal, F. R., de Groot, P. G., & Algra, A. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70239-x · Cited by 429 · see citing works
Schreiber, K. I., Sciascia, S., de Groot, P. G., Devreese, K. M. J., Jacobsen, S., Ruiz‐Irastorza, G., Salmon, J. E., Shoenfeld, Y., Shovman, O., & Hunt, B. J. (2018) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.103 · Cited by 437 · see citing works
de Laat, B., Derksen, R. H. W. M., Urbanus, R. T., & de Groot, P. G. (2005) · Blood · doi:10.1182/blood-2004-09-3387 · Cited by 378 · see citing works
Cervera, R., Bucciarelli, S., Plasín, M. Á., Gómez-Puerta, J. A., Plaza, J., Pons‐Estel, G., Shoenfeld, Y., Ingelmo, M., & Espinos, G. (2009) · Journal of Autoimmunity · doi:10.1016/j.jaut.2009.02.008 · Cited by 357 · see citing works
Tektonidou, M. G., Laskari, K., Panagiotakos, D. B., & Moutsopoulos, H. M. (2009) · Arthritis Care & Research · doi:10.1002/art.24232 · Cited by 356 · see citing works
The clinical relevance of autoantibodies in scleroderma.
Ho, K. T., & Reveille, J. D. (2003) · Arthritis Research · doi:10.1186/ar628 · Cited by 337 · see citing works
Bucciarelli, S., Espinosa, G., Cervera, R., Erkan, D., Gómez-Puerta, J. A., Ramos‐Casals, M., Font, J., & Asherson, R. A. (2006) · Arthritis & Rheumatism · doi:10.1002/art.22018 · Cited by 333 · see citing works
A systematic review of secondary thromboprophylaxis in patients with antiphospholipid antibodies
Ruiz‐Irastorza, G., Hunt, B. J., & Khamashta, M. A. (2007) · Arthritis Care & Research · doi:10.1002/art.23109 · Cited by 324 · see citing works
Rodríguez‐Pintó, I., Moitinho, M., Santacreu, I., Shoenfeld, Y., Erkan, D., Espinosa, G., & Cervera, R. (2016) · Autoimmunity Reviews · doi:10.1016/j.autrev.2016.09.010 · Cited by 315 · see citing works
Raschi, E., Testoni, C., Bosisio, D., Borghi, M. O., Koike, T., Mantovani, A., & Meroni, P. L. (2003) · Blood · doi:10.1182/blood-2002-08-2349 · Cited by 304 · see citing works
Diagnosis and classification of the antiphospholipid syndrome
Gómez-Puerta, J. A., & Cervera, R. (2014) · Journal of Autoimmunity · doi:10.1016/j.jaut.2014.01.006 · Cited by 301 · see citing works
“The baseline characteristics of a cohort of 1000 patients with APS (“Euro-Phospholipid Project”) are collected in Table 3 [17].”
BackgroundCardoso, F., Seppi, K., Mair, K. J., Wenning, G. K., & Poewe, W. H. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70494-x · Cited by 297 · see citing works
DE LAAT, B., PENGO, V., PABINGER, I., MUSIAL, J., VOSKUYL, A. E., BULTINK, I. E. M., RUFFATTI, A., ROZMAN, B., KVEDER, T., DE MOERLOOSE, P., et al. (2009) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2009.03588.x · Cited by 291 · see citing works
Cervera, R., Khamashta, M. A., Shoenfeld, Y., Camps, M. T., Jacobsen, S., Kiss, E., Zeher, M. M., Tincani, A., Kontopoulou-Griva, I., Galeazzi, M., et al. (2009) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2008.093179 · Cited by 286 · see citing works
“these patients when entered in the study have been previously reported.(2) Since then, this cohort of patients has been followed up by the same doctors during the ensuing 5 years.”
BackgroundMethodResultInfluentialCardiovascular disease in autoimmune rheumatic diseases
Hollan, I., Meroni, P. L., Ahearn, J. M., Tervaert, J. W. C., Curran, S., Goodyear, C. S., Hestad, K. A., Kahaleh, B., Riggio, M. P., Shields, K. J., et al. (2013) · Autoimmunity Reviews · doi:10.1016/j.autrev.2013.03.013 · Cited by 273 · see citing works
“A significant morbidity andmortality related to central nervous system andmyocardial arterial vessel involvement has been reported both at the presentation and during the follow-up of the aPL syndrome in large epidemiological studies [16,17].”
BackgroundAntiphospholipid syndrome: advances in diagnosis, pathogenesis, and management
Knight, J. S., Branch, D. W., & Ortel, T. L. (2023) · BMJ · doi:10.1136/bmj-2021-069717 · Cited by 284 · see citing works
Vaccines, adjuvants and autoimmunity
Guimarães, L. E., Baker, B., Perricone, C., & Shoenfeld, Y. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.08.003 · Cited by 264 · see citing works
“Evidence suggests that the molecular mimicry mechanism between 2GPI and TT is one of the possible causes for APS.”
BackgroundInfluentialCervera, R. (2017) · Thrombosis Research · doi:10.1016/s0049-3848(17)30066-x · Cited by 261 · see citing works
Cervera, R., Font, J., Gómez-Puerta, J. A., Espinosa, G., Cucho, M., Bucciarelli, S., Ramos‐Casals, M., Ingelmo, M., Pietté, J. C., Shoenfeld, Y., et al. (2005) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2004.025759 · Cited by 252 · see citing works
“Fortunately, this is an unusual form of presentation that represents fewer than 1% of the APS cases.”
BackgroundBeh, S. C., Greenberg, B. M., Frohman, T. C., & Frohman, E. M. (2012) · Neurologic Clinics · doi:10.1016/j.ncl.2012.09.008 · Cited by 252 · see citing works
Epidemiology, Pathophysiology, and Natural History of Pulmonary Embolism
Turetz, M. L., Sideris, A., Friedman, O., Triphathi, N., & Horowitz, J. M. (2018) · Seminars in Interventional Radiology · doi:10.1055/s-0038-1642036 · Cited by 248 · see citing works
Avčin, T., Cimaz, R., Silverman, E. D., Cervera, R., Gattorno, M., Garay, S. M., Berkun, Y., Sztajnbok, F., Silva, C. A., Campos, L. M. A., et al. (2008) · PEDIATRICS · doi:10.1542/peds.2008-1209 · Cited by 244 · see citing works
“aCL 60 49 (82) 60 48 (80) 120 97 (81) IgG and IgM 54 15 (28) 52 22 (42) 106 37 (35) IgG alone 59 22 (37) 60 20 (33) 119 42 (35) IgM alone 55 12 (22) 52 6 (12) 107 18 (17) Anti- 2GPI 23 16 (70) 25 16 (64) 48 32 (67) IgG and IgM 23 4 (17) 23 5 (22) 46 9 (20) IgG alone 23 8 (35) 25 5 (20) 48 13 (27) IgM alone 23 4 (17) 2…”
Meng, H., Yalavarthi, S., Kanthi, Y. M., Mazza, L. F., Elfline, M. A., Luke, C. E., Pinsky, D. J., Henke, P. K., & Knight, J. S. (2016) · Arthritis & Rheumatology · doi:10.1002/art.39938 · Cited by 233 · see citing works
“events such as venous thrombosis (the most common manifestation of APS) (11).”
Dermatologic manifestations of the antiphospholipid syndrome: Two hundred consecutive cases
Francès, C., Niang, S. O., Laffitte, E., Pelletier, F. L., Costedoat-Chalumeau, N., & Piette, J. C. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21041 · Cited by 229 · see citing works
Population-Level Evidence for an Autoimmune Etiology of Epilepsy
Ong, M.-S., Kohane, I. S., Cai, T., Gorman, M., & Mandl, K. D. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2014.188 · Cited by 228 · see citing works
Relation between migraine and stroke
Bousser, M., & Welch, K. M. A. (2005) · The Lancet Neurology · doi:10.1016/s1474-4422(05)70164-2 · Cited by 228 · see citing works
de Abreu, M. M., Danowski, A., Wahl, D. G., Amigo, M., Tektonidou, M. G., Pacheco, M. D. S., Fleming, N. R. P., Domingues, V., Sciascia, S., Lyra, J. O., et al. (2015) · Autoimmunity Reviews · doi:10.1016/j.autrev.2015.01.002 · Cited by 227 · see citing works
“Ultrasound assessment and exclusion of DVT is essential [9].”
The Euro-Phospholipid project: epidemiology of the antiphospholipid syndrome in Europe
Cervera, R., Boffa, M., Khamashta, M. A., & Hughes, G. (2009) · Lupus · doi:10.1177/0961203309106832 · Cited by 228 · see citing works
Autoantibodies Involved in Neuropsychiatric SLE and Antiphospholipid Syndrome
Zandman‐Goddard, G., Chapman, J., & Shoenfeld, Y. (2007) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2006.11.003 · Cited by 218 · see citing works
Heart involvement in systemic lupus erythematosus, anti-phospholipid syndrome and neonatal lupus
Tincani, A., Rebaioli, C. B., Taglietti, M., & Shoenfeld, Y. (2006) · Lara D. Veeken · doi:10.1093/rheumatology/kel308 · Cited by 216 · see citing works
“Heart valve lesions (vegetation, valve thickening and dysfunction) are frequently reported in patients with APS with and without SLE [39] and in those with aPL alone [40].”
Cervera, R., Rodríguez‐Pintó, I., & Espinosa, G. (2018) · Journal of Autoimmunity · doi:10.1016/j.jaut.2018.05.007 · Cited by 219 · see citing works
Alijotas‐Reig, J., Esteve‐Valverde, E., Ferrer‐Oliveras, R., Comet, L. S., Lefkou, E. E., MEKINIAN, A., Belizna, C. C., Ruffatti, A., Tincani, A., Marozio, L., et al. (2019) · Autoimmunity Reviews · doi:10.1016/j.autrev.2018.12.006 · Cited by 215 · see citing works
Mulla, M. J., Brosens, J. J., Chamley, L., Giles, I., Pericleous, C., Rahman, A., Joyce, S. K., Panda, B., Paidas, M. J., & Abrahams, V. M. (2009) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2009.00717.x · Cited by 207 · see citing works
The clinical significance of antiphospholipid antibodies in systemic lupus erythematosus
Ünlü, O., Zuily, S., & Erkan, D. (2015) · European Journal of Rheumatology · doi:10.5152/eurjrheum.2015.0085 · Cited by 210 · see citing works
Infectious origin of the antiphospholipid syndrome
Shoenfeld, Y., Blank, M., Cervera, R., Font, J., Raschi, E., & Meroni, P. L. (2005) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2005.045443 · Cited by 206 · see citing works
Autoantibody profiles in systemic sclerosis: Predictive value for clinical evaluation and prognosis
Hamaguchi, Y. (2010) · The Journal of Dermatology · doi:10.1111/j.1346-8138.2009.00762.x · Cited by 201 · see citing works
The antiphospholipid syndrome in patients with systemic lupus erythematosus
Pons‐Estel, G., Andréoli, L., Scanzi, F., Cervera, R., & Tincani, A. (2016) · Journal of Autoimmunity · doi:10.1016/j.jaut.2016.10.004 · Cited by 203 · see citing works
“It started in 1999 as an attempt to describe the epidemiology and the course of APS in real life in European patients [3].”
BackgroundInfluentialAdenosine receptor agonism protects against NETosis and thrombosis in antiphospholipid syndrome
Ali, R. A., Gandhi, A. A., Meng, H., Yalavarthi, S., Vreede, A. P., Estes, S. K., Palmer, O. R., Bockenstedt, P. L., Pinsky, D. J., Greve, J. M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09801-x · Cited by 200 · see citing works
Shapira, I., ANDRADE, D. C. O. D., Allen, S. L., & Salmon, J. E. (2012) · Arthritis & Rheumatism · doi:10.1002/art.34440 · Cited by 198 · see citing works
DANOWSKI, A., de AZEVEDO, M. N. L., de SOUZA PAPI, J. A., & PETRI, M. (2009) · The Journal of Rheumatology · doi:10.3899/jrheum.081194 · Cited by 192 · see citing works
“56 Diabetes mellitus 1 (6) 4 (7) 1 (2) 0.”
Antiphospholipid antibodies, antiphospholipid syndrome and infections
Sène, D., Pietté, J. C., & Cacoub, P. (2007) · Autoimmunity Reviews · doi:10.1016/j.autrev.2007.10.001 · Cited by 190 · see citing works
Diagnosis and management of the antiphospholipid syndrome
Chaturvedi, S., & McCrae, K. R. (2017) · Blood Reviews · doi:10.1016/j.blre.2017.07.006 · Cited by 191 · see citing works
Oxidative modification of low-density lipoprotein and immune regulation of atherosclerosis
Matsuura, E., Kobayashi, K., TABUCHI, M., & LOPEZ, L. (2006) · Progress in Lipid Research · doi:10.1016/j.plipres.2006.05.001 · Cited by 183 · see citing works
The complement system and human autoimmune diseases
Coss, S. L., Zhou, D., Chua, G. T., Abdul‐Aziz, R., Hoffman, R. P., Wu, Y. L., Ardoin, S. P., Atkinson, J. P., & Yu, C. Y. (2022) · Journal of Autoimmunity · doi:10.1016/j.jaut.2022.102979 · Cited by 187 · see citing works
Lauretis, A. D., Veeraraghavan, S., & Renzoni, E. A. (2011) · Chronic Respiratory Disease · doi:10.1177/1479972310393758 · Cited by 180 · see citing works
The implications of autoimmunity and pregnancy
Borchers, A. T., Naguwa, S. M., Keen, C. L., & Gershwin, M. E. (2009) · Journal of Autoimmunity · doi:10.1016/j.jaut.2009.11.015 · Cited by 179 · see citing works
McClain, M. T., Arbuckle, M. R., Heinlen, L. D., Dennis, G. J., Roebuck, J., Rubertone, M. V., Harley, J. B., & James, J. A. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20120 · Cited by 177 · see citing works
Ramos‐Casals, M., Brito‐Zerón, P., Kostov, B., Sisó‐Almirall, A., Bosch, X., Buss, D., Trilla, A., Stone, J. H., Khamashta, M. A., & Shoenfeld, Y. (2015) · Autoimmunity Reviews · doi:10.1016/j.autrev.2015.03.008 · Cited by 176 · see citing works
Epidemiology and Etiology of Young Stroke
Griffiths, D., & Sturm, J. W. (2011) · Stroke Research and Treatment · doi:10.4061/2011/209370 · Cited by 179 · see citing works
“Ischaemic stroke was the most common presentation of arterial thrombosis in 1000 patients (mean age 42 ± 14 years) fulfilling the Sapporo criteria [80, 94] for antiphospholipid syndrome (stroke was the incident event in 13% of patients and TIA in 7%) in a large cohort study [95].”
MethodAutoantibodies against the fibrinolytic receptor, annexin 2, in antiphospholipid syndrome
Cesarman-Maus, G. N., Ríos-Luna, N. P., Deora, A. B., Huang, B., Villa, R., Cravioto, M. D. C., Alarcón-Segovia, D., Sánchez‐Guerrero, J., & Hajjar, K. A. (2006) · Blood · doi:10.1182/blood-2005-07-2636 · Cited by 174 · see citing works
McDonnell, T. C. R., Wincup, C., Buchholz, I., Pericleous, C., Giles, I., Ripoll, V. M., Cohen, H., Delcea, M., & Rahman, A. (2019) · Blood Reviews · doi:10.1016/j.blre.2019.100610 · Cited by 169 · see citing works
“leading cause of strokes in people under 50 years old [8].”
BackgroundDufrost, V., Risse, J., Reshetnyak, T. M., Satybaldyeva, M. A., Du, Y., Yan, X.-X., Salta, S., Gerotziafas, G., Jing, Z., Elalamy, I., et al. (2018) · Autoimmunity Reviews · doi:10.1016/j.autrev.2018.04.009 · Cited by 162 · see citing works
Childhood systemic lupus erythematosus in Latin America. The GLADEL experience in 230 children
Gómez, L. R., Uribe, Ó. U., Uribe, Ó. O., Romero, H. G., Cardiel, M. H., WOJDYLA, D. M., Pons‐Estel, B. A., & (GLADEL), O. B. O. T. G. L. D. E. D. L. E. (2008) · Lupus · doi:10.1177/0961203307088006 · Cited by 158 · see citing works
Coronary Heart Disease in Young Adults
Rubin, J. B., & Borden, W. B. (2012) · Current Atherosclerosis Reports · doi:10.1007/s11883-012-0226-3 · Cited by 157 · see citing works
“8% in a large study of APLS patients [57].”
BackgroundMoroni, G. L., Ventura, D., Riva, P., Panzeri, P., Quaglini, S., Banfi, G., Simonini, P., Bader, R., Meroni, P. L., & Ponticelli, C. E. (2004) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2003.09.011 · Cited by 153 · see citing works
Zuily, S., Cohen, H., Isenberg, D. A., Woller, S. C., Crowther, M. A., Dufrost, V., Wahl, D. G., Doré, C. J., Cuker, A. C., Carrier, M., et al. (2020) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.14935 · Cited by 156 · see citing works
Streiff, M. B., Holmstrom, B., Angelini, D. E., Ashrani, A. A., Elshoury, A., Fanikos, J. R., Fertrin, K. Y., Fogerty, A. E., Gao, S., Goldhaber, S. Z., et al. (2021) · PubMed · doi:10.6004/jnccn.2021.0047 · Cited by 149 · see citing works
Alijotas‐Reig, J., Ferrer‐Oliveras, R., Ruffatti, A., Tincani, A., Lefkou, E. E., Bertero, M. T., Coloma, E., Carolis, S. D., Espinosa, G., Rovere, P. Q., et al. (2014) · Autoimmunity Reviews · doi:10.1016/j.autrev.2014.12.010 · Cited by 152 · see citing works
Alén, J. C., Toloza, S., Fernández, M., Bastian, H. M., Fessler, B. J., Roseman, J. M., McGwin, G., Vilá, L. M., Reveille, J. D., Alarcón, G. S., et al. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21149 · Cited by 147 · see citing works
Antiphospholipid syndrome: an overview.
Hanly, J. G. (2003) · Europe PMC (PubMed Central) · Cited by 141 · see citing works
The significance of autoantibodies against β2-glycoprotein I
de Groot, P. G., & Urbanus, R. T. (2012) · Blood · doi:10.1182/blood-2012-03-378646 · Cited by 146 · see citing works
Abdel‐Wahab, N., Talathi, S., Lopez-Olivo, M. A., & Suarez-Almazor, M. E. (2017) · Lupus · doi:10.1177/0961203317731532 · Cited by 148 · see citing works
Demyelination in rheumatic diseases
Theodoridou, A., & Settas, L. (2006) · Postgraduate Medical Journal · doi:10.1136/jnnp.2005.075861 · Cited by 145 · see citing works
Cohen, H., Cuadrado, M. J., Erkan, D., Duarte‐García, A., Isenberg, D. A., Knight, J. S., Ortel, T. L., Rahman, A., Salmon, J. E., Tektonidou, M. G., et al. (2020) · Lupus · doi:10.1177/0961203320950461 · Cited by 165 · see citing works
“The overall prevalence of APS has been estimated at 50 per 100,000 people,(2) with a female-to-male ratio of approximately 5:1.(3) Thrombosis, a cardinal disease manifestation, may be venous, arterial, or microvascular.”
BackgroundAntiphospholipid Syndrome Infectious Origin
Blank, M., Asherson, R. A., Cervera, R., & Shoenfeld, Y. (2004) · Journal of Clinical Immunology · doi:10.1023/b:joci.0000018058.28764.ce · Cited by 141 · see citing works
Cognitive Deficits in Patients With Antiphospholipid Syndrome
Tektonidou, M. G. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.20.2278 · Cited by 139 · see citing works
Systematic review of case reports of antiphospholipid syndrome following infection
Abdel‐Wahab, N., Lopez-Olivo, M. A., Pinto-Patarroyo, G. P., & Suarez-Almazor, M. E. (2016) · Lupus · doi:10.1177/0961203316640912 · Cited by 137 · see citing works
Gómez-Puerta, J. A., Cervera, R., Espinosa, G., Aguiló, S., Bucciarelli, S., Ramos‐Casals, M., Ingelmo, M., Asherson, R. A., & Font, J. (2006) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2005.07.003 · Cited by 138 · see citing works
Gibbs, M., English, J. C., & Zirwas, M. (2005) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2004.11.051 · Cited by 138 · see citing works
Multiple sclerosis, neuropsychiatric lupus and antiphospholipid syndrome: where do we stand?
Ferreira, S. (2005) · British journal of rheumatology · doi:10.1093/rheumatology/keh532 · Cited by 137 · see citing works
“In the Euro-Phospholipid Project cohort of 1000 European APS patients (primary and secondary), myelopathy and optic neuropathy were rare manifestations (0.4 and 1%, respectively) [ 36 ].”
BackgroundInfluentialTreatment of catastrophic antiphospholipid syndrome
Kazzaz, N. M., McCune, W. J., & Knight, J. S. (2016) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000269 · Cited by 134 · see citing works
Ioannou, Y., Pericleous, C., Giles, I., Latchman, D. S., Isenberg, D. A., & Rahman, A. (2006) · Arthritis & Rheumatism · doi:10.1002/art.22306 · Cited by 131 · see citing works
“The clinical features of patients in the APS group were representative of the features of patients in larger epidemiologic studies of APS (35).”
ResultHo, K. T., Ahn, C. W., Alarcón, G. S., Baethge, B. A., Tan, F. K., Roseman, J., Bastian, H. M., Fessler, B. J., McGwin, G., Vilá, L. M., et al. (2005) · Rheumatology · doi:10.1093/rheumatology/kei014 · Cited by 128 · see citing works
“Contrary to what we had hypothesized based on the published literature [2, 9, 39–41], an association between aPL antibodies (each one individually or all taken together) was not found in either the univariable or the multivariable analyses even when a second assay was performed in a selected number of patient samples…”
ResultCardiac Manifestations of Antiphospholipid Syndrome With Focus on Its Primary Form
Kolitz, T., Shiber, S., Sharabi, I., Winder, A., & Zandman‐Goddard, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00941 · Cited by 134 · see citing works
Cardiac pathology of systemic lupus erythematosus
Jain, D., & Halushka, M. K. (2009) · Journal of Clinical Pathology · doi:10.1136/jcp.2009.064311 · Cited by 127 · see citing works
Diagnosis and management of the antiphospholipid syndrome
Cohen, D. B., Berger, S. P., Steup‐Beekman, G. M., Bloemenkamp, K. W. M., & Bajema, I. M. (2010) · BMJ · doi:10.1136/bmj.c2541 · Cited by 124 · see citing works
“Antiphospholipid syndrome is a systemic autoimmune disorder characterised by arterial and venous thrombosis, adverse outcomes in pregnancy (for mother and fetus), and raised titres of antiphospholipid antibodies. It occurs in isolation (primary antiphospholipid syndrome) in more than 50% of patients, but it can be ass…”
BackgroundAlijotas‐Reig, J., Esteve‐Valverde, E., Anunciación-Llunell, A., Marques-Soares, J. R., Pardos‐Gea, J., & Miró‐Mur, F. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11030675 · Cited by 127 · see citing works
Chronic Inflammatory Placental Disorders Associated With Recurrent Adverse Pregnancy Outcome
Cornish, E. F., McDonnell, T. C. R., & Williams, D. J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.825075 · Cited by 118 · see citing works
The Hematologic Manifestations of the Antiphospholipid Syndrome
Uthman, I. W., Godeau, B., Taher, A. T., & Khamashta, M. A. (2008) · Blood Reviews · doi:10.1016/j.blre.2008.03.005 · Cited by 118 · see citing works
Antiphospholipid syndrome and recurrent thrombosis in children
Berkun, Y., Padeh, S., Barash, J., Uziel, Y., Harel, L., Mukamel, M., Revel‐Vilk, S., & Kenet, G. (2006) · Arthritis Care & Research · doi:10.1002/art.22360 · Cited by 118 · see citing works
Neurological manifestations of antiphospholipid syndrome
Rodrigues, C. E. M., de Carvalho, J. F., & Shoenfeld, Y. (2010) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2010.02263.x · Cited by 116 · see citing works
The antiphospholipid syndrome: from pathophysiology to treatment
Negrini, S. M., Pappalardo, F., Murdaca, G., Indiveri, F., & Puppo, F. (2016) · Clinical and Experimental Medicine · doi:10.1007/s10238-016-0430-5 · Cited by 117 · see citing works
“Venous thromboembolism is the most frequent manifestation in APS patients, and differently from thrombosis in congenital thrombophilias, all segments of the vascular bed (both venous and arterial) can be involved in any combination of occlusive events [2].”
BackgroundInfluentialAntiphospholipid Syndrome during pregnancy: the state of the art.
Prima, F. A. F. D., Valenti, O., Hyseni, E., Giorgio, E., Faraci, M., Renda, E., Domenico, R. D., & Monte, S. (2011) · PubMed Central · Cited by 111 · see citing works
Management of antiphospholipid syndrome
Uthman, I. W., Noureldine, M. H. A., Ruiz‐Irastorza, G., & Khamashta, M. A. (2018) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2018-213846 · Cited by 112 · see citing works
“In an attempt to assess the risk of developing the clinical manifestations related to vascular thrombosis and pregnancy morbidity in patients with APS, the first Risk Scale for the diagnosis of APS was proposed in 2011.”
InfluentialGómez-Puerta, J. A., Cervera, R., Espinosa, G., Asherson, R. A., García‐Carrasco, M., da Costa, I. P., ANDRADE, D. C. O. D., Borba, E. F., Makatsaria, A. D., Bucciarelli, S., et al. (2007) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2006.061671 · Cited by 112 · see citing works
“The antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterised by a combination of arterial and/or venous thrombosis, pregnancy morbidity, usually accompanied by a mild-to-moderate thrombocytopenia, and raised titres of antiphospholipid antibodies (aPL)—namely, the lupus anticoagulant (LA) and/or…”
BackgroundEspinosa, G., Mendizábal, A., Mínguez, S., Ramo-Tello, C. M., Capellades, J., Olivé, A., & Cervera, R. (2008) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2008.09.002 · Cited by 112 · see citing works
- Authors
- Cervera, R., Piette, J., Font, J., Khamashta, M. A., Shoenfeld, Y., Camps, M. T., Jacobsen, S., Lakos, G., Tincani, A., Kontopoulou‐Griva, I., Galeazzi, M., Meroni, P. L., Derksen, R. H. W. M., de Groot, P. G., Gromnica‐Ihle, E., Baleva, M., Mosca, M., Bombardieri, S., Houssiau, F., Gris, J., Quéré, I., Hachulla, E., Vasconcelos, C., Roch, B., Fernández‐Nebro, A., Boffa, M., Hughes, G. R. V., & Ingelmo, M.
- Affiliations
- Hospital Clínic de Barcelona (ES)
- St Thomas' Hospital (GB)
- Sheba Medical Center (IL)
- Hospital Regional Universitario de Málaga (ES)
- University of Debrecen (HU)
- Hippocration General Hospital (GR)
- Ospedale Santa Maria alle Scotte (IT)
- University of Milan (IT)
- University Medical Center Utrecht (NL)
- Immanuel Krankenhaus (DE)
- Medical University of Sofia (BG)
- University of Pisa (IT)
- Cliniques Universitaires Saint-Luc (BE)
- Centre Hospitalier Universitaire de Nîmes (FR)
- Hôpital Claude Huriez (FR)
- Hospital de Santo António (PT)
- University Hospital Carl Gustav Carus (DE)
- Pitié-Salpêtrière Hospital (FR)
- Corresponding author
- Cervera, Ricard
- ORCID
- Venue
- Arthritis & Rheumatism
- Publisher
- Wiley
- Published
- 2002-04
- Volume
- 46
- Issue
- 4
- Pages
- 1019-1027
- ISSN
- 0004-3591 (ISSN-L)
- 1529-0131
- OpenAlex
- W2042958596
- Cited by
- 2,156
- References
- 42
- Citations by year
- 2026: 60 · 2025: 82 · 2024: 110 · 2023: 93 · 2022: 106 · 2021: 130 · 2020: 92 · 2019: 110 · 2018: 99 · 2017: 95 · 2016: 84 · 2015: 94 · 2014: 96 · 2013: 82 · 2012: 85
- FWCI
- 43.59
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Arthritis & Rheumatism (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
- University of Debrecen Electronic Archive (University of Debrecen) (submittedVersion, other-oa)
- Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion)
- Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Use Siena air (University of Siena) (submittedVersion)
- Funders
- Comissió Interdepartamental per a la Recerca i la Tecnologia of Catalonia, Spain ((FI/FIAP 1999/00684))
- Fondo de Investigaciones Sanitarias of Spain ((FIS 1999/280))
- IRCCS Istituto Auxologico Italiano of Italy (Ricerca Corrente 2000)
- Institut Electricité-Santé of France
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Vasculitis and related conditions
- Health Sciences › Medicine › Pathology and Forensic Medicine › Systemic Sclerosis and Related Diseases
- Keywords
- antiphospholipid syndrome, systemic lupus erythematosus, thrombosis, catastrophic antiphospholipid syndrome, sex differences, age of onset, livedo reticularis, thrombocytopenia, leukopenia, stroke, myocardial infarction, arterial thrombosis, lupus-like syndrome, chorea, migraine, epilepsy, angina pectoris
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Autoantibodies, Child, Child, Preschool, Diagnosis, Differential, Female, Humans, Infant, Infant, Newborn, Male, Middle Aged, Cohort Studies, Prevalence, Antiphospholipid Syndrome, Age Distribution, Sex Distribution, Lupus Vasculitis, Central Nervous System
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