Cited by 111Mitochondrial Function and PathologyMetabolism, Diabetes, and CancerAutophagy in Disease and Therapy

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Diabetes-induced up-regulation of uncoupling protein-2 results in increased mitochondrial uncoupling in kidney proximal tubular cells

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Friederich, Malou, Fasching, Angelica, Hansell, Peter, Nordquist, Lina, Palm, Fredrik·2008·Biochimica et Biophysica Acta (BBA) - Bioenergetics

DOI 10.1016/j.bbabio.2008.03.030

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Abstract

We have previously reported increased O(2) consumption unrelated to active transport by tubular cells and up-regulated mitochondrial uncoupling protein (UCP)-2 expressions in diabetic kidneys. It is presently unknown if the increased UCP-2 levels in the diabetic kidney results in mitochondrial uncoupling and increased O(2) consumption, which we therefore investigated in this study. The presence of UCP-2 in proximal tubular cells was confirmed by immunohistochemistry and found to be increased (western blot) in homogenized tissue and isolated mitochondria from kidney cortex of diabetic rats. Isolated proximal tubular cells had increased total and ouabain-insensitive O(2) consumption compared to controls. Isolated mitochondria from diabetic animals displayed increased glutamate-stimulated O(2) consumption (in the absence of ADP and during inhibition of the ATP-synthase by oligomycin) compared to controls. Guanosine diphosphate, an UCP inhibitor, and bovine serum albumin which removes fatty acids that are essential for UCP-2 uncoupling activity, independently prevented the increased glutamate-stimulated O(2) consumption in mitochondria from diabetic animals. In conclusion, diabetic rats have increased mitochondrial UCP-2 expression in renal proximal tubular cells, which results in mitochondrial uncoupling and increased O(2) consumption. This mechanism may be protective against diabetes-induced oxidative stress, but will increase O(2) usage. The subsequently reduced O(2) availability may contribute to diabetes-induced progressive kidney damage.

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Nishikawa, T., Edelstein, D., Du, X. L., Yamagishi, S.-I., Matsumura, T., Kaneda, Y., Yorek, M. A., Beebe, D., Oates, P. J., Hammes, H.-P., et al. (2000) · Nature · doi:10.1038/35008121 · Cited by 4,277
High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria
Korshunov, S. S., Skulachev, V. P., & Starkov, A. A. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01159-9 · Cited by 1,727
Topology of superoxide production from different sites in the mitochondrial electron transport chain
St-Pierre, J., Buckingham, J. A., Roebuck, S. J., & Brand, M. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207217200 · Cited by 1,545
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Rolo, A. P., & Palmeira, C. M. (2006) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2006.01.003 · Cited by 1,007
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Sweadner, K. J. (1989) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(89)90019-1 · Cited by 953
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Authors: Friederich, M., Fasching, A., Hansell, P., Nordquist, L., & Palm, F.
Affiliations: Uppsala University (SE)
Corresponding author: Palm, Fredrik
ORCID: Hansell, Peter
Nordquist, Lina
Palm, Fredrik
Venue: Biochimica et Biophysica Acta (BBA) - Bioenergetics
Publisher: Elsevier BV
Published: 2008-07
Volume: 1777
Issue: 7-8
Pages: 935-940
ISSN: 0005-2728 (ISSN-L)
DOI: 10.1016/j.bbabio.2008.03.030
OpenAlex: W2084502320
Cited by: 111
References: 29
Citations by year: 2026: 3 · 2025: 1 · 2024: 4 · 2023: 6 · 2022: 5 · 2021: 6 · 2020: 9 · 2019: 7 · 2018: 9 · 2017: 7 · 2016: 6 · 2015: 4 · 2014: 11 · 2013: 5 · 2012: 12
FWCI: 2.20
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1843 d)
Locations: Biochimica et Biophysica Acta (BBA) - Bioenergetics (publishedVersion)
PubMed (publishedVersion)
Funders: Fondation pour la Recherche Médicale
Svenska Sällskapet för Medicinsk Forskning
Stiftelsen Familjen Ernfors Fond
Marcus och Amalia Wallenbergs minnesfond
National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (K99DK077858)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Keywords: UCP2, mitochondrial uncoupling, diabetes mellitus, diabetic kidney, proximal tubular epithelial cells, oxygen consumption, oxidative stress, kidney injury, guanosine diphosphate, fatty acids
MeSH terms: Uncoupling Protein 2, Animals, Diabetes Mellitus, Experimental, Hyperglycemia, Insulin, Ion Channels, Kidney Tubules, Proximal, Male, Mitochondria, Oxygen Consumption, Rats, Inbred WF, Up-Regulation, Mitochondrial Proteins, Rats

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Diabetes-induced up-regulation of uncoupling protein-2 results in increased mitochondrial uncoupling in kidney proximal tubular cells

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