Towards a better understanding of carotenoid metabolism in animals
Open accessAbstract
Vitamin A derivatives (retinoids) are essential components in vision; they contribute to pattern formation during development and exert multiple effects on cell differentiation with important clinical implications. All naturally occurring vitamin A derives by enzymatic oxidative cleavage from carotenoids with pro-vitamin A activity. To become biologically active, these plant-derived compounds must first be absorbed, then delivered to the site of action in the body, and metabolically converted to the real vitamin. Recently, molecular players of this pathway were identified by the analysis of blind Drosophila mutants. Similar genome sequences were found in vertebrates. Subsequently, these homologous genes were cloned and their gene products were functionally characterized. This review will summarize the advanced state of knowledge about the vitamin A biosynthetic pathway and will discuss biochemical, physiological, developmental and medical aspects of carotenoids and their numerous derivatives.
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CCOs cleave the carotenoid polyene backbone with high stereoselectivity and regioselectivity.
“CCOs are characterized by their ability to cleave the carotenoid polyene backbone with high stereoselectivity and regioselectivity, thus cleaving only selected polyenes at specific sites leaving specific products with very high fidelity [13,14,15].”
From Vitamin A Transporters in Visual Function: A Mini Review on Membrane Receptors for Dietary Vitamin A Uptake, Storage, and Transport to the Eye (2021) · cites this paper as [15]
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- Authors
- von Lintig, J., Hessel, S., Isken, A., Kiefer, C., Lampert, J. M., Voolstra, O., & Vogt, K.
- Affiliations
- University of Freiburg (DE)
- ORCID
- Voolstra, Olaf
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Publisher
- Elsevier BV
- Published
- 2005-05
- Volume
- 1740
- Issue
- 2
- Pages
- 122-131
- ISSN
- 0925-4439 (ISSN-L)
- OpenAlex
- W2030342811
- Cited by
- 116
- References
- 8
- Citations by year
- 2026: 4 · 2024: 2 · 2023: 6 · 2021: 10 · 2020: 6 · 2019: 5 · 2018: 4 · 2017: 5 · 2016: 4 · 2015: 3 · 2014: 4 · 2013: 8 · 2012: 8
- FWCI
- 0.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Eye Institute (R01EY020551)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- carotenoid metabolism, vitamin A biosynthesis, retinoids, provitamin A, beta-carotene cleavage, Drosophila mutants, gene cloning, vision, pattern formation, cell differentiation, vitamin A deficiency
- MeSH terms
- Retinoid Isomerohydrolase, Animals, Carotenoids, Carrier Proteins, Eye Proteins, Humans, Intestinal Mucosa, Oxygenases, Receptors, Immunologic, Tretinoin, Vitamin A, cis-trans-Isomerases, Dioxygenases, beta-Carotene 15,15'-Monooxygenase, Receptors, Scavenger
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