Mammalian Carotenoid-oxygenases: Key players for carotenoid function and homeostasis

Lobo, Glenn P.; Amengual, Jaume; Palczewski, Grzegorz; Babino, Darwin; von Lintig, Johannes

doi:10.1016/j.bbalip.2011.04.010

Cited by 125Antioxidant Activity and Oxidative StressRetinoids in leukemia and cellular processesPlant biochemistry and biosynthesis

Mammalian Carotenoid-oxygenases: Key players for carotenoid function and homeostasis

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Lobo, Glenn P., Amengual, Jaume, Palczewski, Grzegorz, Babino, Darwin, von Lintig, Johannes·2012·Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

DOI 10.1016/j.bbalip.2011.04.010PMC PMC3162997

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Abstract

Humans depend on a dietary intake of lipids to maintain optimal health. Among various classes of dietary lipids, the physiological importance of carotenoids is still controversially discussed. On one hand, it is well established that carotenoids, such as β,β-carotene, are a major source for vitamin A that plays critical roles for vision and many aspects of cell physiology. On the other hand, large clinical trials have failed to show clear health benefits of carotenoids supplementation and even suggest adverse health effects in individuals at risk of disease. In recent years, key molecular players for carotenoid metabolism have been identified, including an evolutionarily well conserved family of carotenoid-oxygenases. Studies in knockout mouse models for these enzymes revealed that carotenoid metabolism is a highly regulated process and that this regulation already takes place at the level of intestinal absorption. These studies also provided evidence that β,β-carotene conversion can influence retinoid-dependent processes in the mouse embryo and in adult tissues. Moreover, these analyses provide an explanation for adverse health effects of carotenoids by showing that a pathological accumulation of these compounds can induce oxidative stress in mitochondria and cell signaling pathways related to disease. Advancing knowledge about carotenoid metabolism will contribute to a better understanding of the biochemical and physiological roles of these important micronutrients in health and disease. This article is part of a Special Issue entitled Retinoid and Lipid Metabolism.

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CCOs cleave the carotenoid polyene backbone with high stereoselectivity and regioselectivity.
“CCOs are characterized by their ability to cleave the carotenoid polyene backbone with high stereoselectivity and regioselectivity, thus cleaving only selected polyenes at specific sites leaving specific products with very high fidelity [13,14,15].”
From Vitamin A Transporters in Visual Function: A Mini Review on Membrane Receptors for Dietary Vitamin A Uptake, Storage, and Transport to the Eye (2021) · cites this paper as [13]
The section “Mammalian genomes encode three different CCE family members” says BCMO1 and BCDO2 cleave distinct bonds in the carotenoid polyene backbone and describes their substrate specificity, supporting regioselective cleavage. The section “Out of the green wild yonder” discusses cis–trans isomerization, but does not establish high stereoselectivity of the cleavage reaction; in mammals, it assigns cleavage and isomerization to different enzymes. No page numbers are available in our copy. (LLM, conf=0.85)
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BCO1 catalyzes the cleavage of β-carotene taken in through SCARB1 into two molecules of retinal through symmetrical cleavage.
“In the β-carotene metabolic pathway, BCO1 catalyzes the cleavage of β-carotene taken in through SCARB1 into two molecules of retinal through symmetrical cleavage of β-carotene.”
From Vitamin A Transporters in Visual Function: A Mini Review on Membrane Receptors for Dietary Vitamin A Uptake, Storage, and Transport to the Eye (2021) · cites this paper as [13]

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NinaB combines carotenoid oxygenase and retinoid isomerase activity in a single polypeptide
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Loss of Carotene-9′,10'-Monooxygenase Expression Increases Serum and Tissue Lycopene Concentrations in Lycopene-Fed Mice
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Lycopene Biodistribution Is Altered in 15,15´-Carotenoid Monooxygenase Knockout Mice3
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Biochemical evidence for the tyrosine involvement in cationic intermediate stabilization in mouse β-carotene 15, 15'-monooxygenase
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Lipidology
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Rhodopsin-mediated photosensing in green flagellated algae
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[59]Leung WC Hessel S Meplan C Flint J Oberhauser V Tourniaire F Hesketh JE von Lintig J Lietz G Two common single nucleotide polymorphisms in the gene encoding {beta}-carotene 15,15′-monoxygenase alter {beta}-carotene metabolism in female volunteers Faseb J 2008 19103647

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Authors: Lobo, G. P., Amengual, J., Palczewski, G., Babino, D., & von Lintig, J.
Affiliations: Case Western Reserve University (US)
ORCID: Lobo, Glenn P.
Amengual, Jaume
Babino, Darwin
Venue: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Publisher: Elsevier BV
Published: 2012-01
Volume: 1821
Issue: 1
Pages: 78-87
ISSN: 1388-1981 (ISSN-L)
DOI: 10.1016/j.bbalip.2011.04.010
PMC: PMC3162997
OpenAlex: W2046674715
Cited by: 125
References: 125
Citations by year: 2026: 4 · 2025: 6 · 2024: 6 · 2023: 8 · 2022: 6 · 2021: 7 · 2020: 6 · 2019: 5 · 2018: 12 · 2017: 8 · 2016: 10 · 2015: 13 · 2014: 6 · 2013: 14 · 2012: 13
FWCI: 1.01
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Health (EY019641)
Topics: Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
Keywords: carotenoid metabolism, vitamin A, retinoids, intestinal absorption, knockout mouse models, oxidative stress, mitochondrial stress, carotenoid accumulation, dietary carotenoids, carotenoid supplementation
MeSH terms: Animals, Carotenoids, Homeostasis, Humans, Intestinal Absorption, Liver, Mitochondria, Liver, Oxygenases, Vitamin A, Signal Transduction, Mice, Knockout, Oxidative Stress, beta-Carotene 15,15'-Monooxygenase, Mice

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Mammalian Carotenoid-oxygenases: Key players for carotenoid function and homeostasis

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