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Pharmacological antioxidant strategies as therapeutic interventions for COPD
Open accessAbstract
Cigarette/tobacco smoke/biomass fuel-induced oxidative and aldehyde/carbonyl stress are intimately associated with the progression and exacerbation of chronic obstructive pulmonary disease (COPD). Therefore, targeting systemic and local oxidative stress with antioxidants/redox modulating agents, or boosting the endogenous levels of antioxidants are likely to have beneficial effects in the treatment/management of COPD. Various antioxidant agents, such as thiol molecules (glutathione and mucolytic drugs, such as N-acetyl-L-cysteine and N-acystelyn, erdosteine, fudosteine, ergothioneine, and carbocysteine), have been reported to modulate various cellular and biochemical aspects of COPD. These antioxidants have been found to scavenge and detoxify free radicals and oxidants, regulate of glutathione biosynthesis, control nuclear factor-kappaB (NF-kappaB) activation, and hence inhibiting inflammatory gene expression. Synthetic molecules, such as specific spin traps like α-phenyl-N-tert-butyl nitrone, a catalytic antioxidant (ECSOD mimetic), porphyrins (AEOL 10150 and AEOL 10113), and a superoxide dismutase mimetic M40419, iNOS and myeloperoxidase inhibitors, lipid peroxidation inhibitors/blockers edaravone, and lazaroids/tirilazad have also been shown to have beneficial effects by inhibiting cigarette smoke-induced inflammatory responses and other carbonyl/oxidative stress-induced cellular alterations. A variety of oxidants, free radicals, and carbonyls/aldehydes are implicated in the pathogenesis of COPD, it is therefore, possible that therapeutic administration or supplementation of multiple antioxidants and/or boosting the endogenous levels of antioxidants will be beneficial in the treatment of COPD. This review discusses various novel pharmacological approaches adopted to enhance lung antioxidant levels, and various emerging beneficial and/or prophylactic effects of antioxidant therapeutics in halting or intervening the progression of COPD. This article is part of a Special Issue entitled: Antioxidants and Antioxidant Treatment in Disease.
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“ERG has been found to be an effective antioxidant in cardiovascular diseases (Servillo et al. 2017), chronic pulmonary diseases (Rahman 2012), lung inflammatory diseases (Repine and Elkins 2012), and other pathologies.”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Rahman 2012
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Metadata
- Authors
- Rahman, I.
- Affiliations
- University of Rochester Medicine (US)
- Corresponding author
- Rahman, Irfan
- ORCID
- Rahman, Irfan
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Publisher
- Elsevier BV
- Published
- 2012-05
- Volume
- 1822
- Issue
- 5
- Pages
- 714-728
- ISSN
- 0925-4439 (ISSN-L)
- PMC
- PMC3295924
- OpenAlex
- W2123397711
- Cited by
- 117
- References
- 192
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 7 · 2023: 10 · 2022: 8 · 2021: 10 · 2020: 3 · 2019: 6 · 2018: 9 · 2017: 10 · 2016: 8 · 2015: 8 · 2014: 16 · 2013: 10 · 2012: 7
- FWCI
- 1.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- Funders
- National Institutes of Health (5r01hl097751-04, ES01247, 1R01HL097751)
- National Heart, Lung, and Blood Institute (1R01HL097751, R01HL092842, R01-HL097751, R01HL085613)
- National Institute of Environmental Health Sciences (ES-01247, P30ES001247)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- chronic obstructive pulmonary disease, antioxidants, oxidative stress, carbonyl stress, thiols, glutathione, N-acetylcysteine, erdosteine, ergothioneine, carbocysteine, spin traps, superoxide dismutase mimetic, porphyrins, edaravone, lazaroids, tirilazad, NF-κB, inflammation, cigarette smoke, biomass fuel, lipid peroxidation, antioxidant therapeutics
- MeSH terms
- Antioxidants, Humans, Pulmonary Disease, Chronic Obstructive
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