The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
ROCK1/p53/NOXA signaling mediates cardiomyocyte apoptosis in response to high glucose in vitro and vivo
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“ROCK1 increases p53 protein levels by phosphorylating p53 at Ser15.297”
From p53: from understanding its structure to advances in therapeutic targeting (2026) · cites this paper as [297]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
p53- and Drug-Induced Apoptotic Responses Mediated by BH3-Only Proteins Puma and Noxa
Villunger, A., Michalak, E. M., Coultas, L., Müllauer, F., Böck, G., Ausserlechner, M. J., Adams, J. M., & Strasser, A. (2003) · Science · doi:10.1126/science.1090072 · Cited by 1,327
Post-translational modification of p53 in tumorigenesis
Bode, A. M., & Dong, Z. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1455 · Cited by 1,270
N-Acetylcysteine prevents congenital heart defects induced by pregestational diabetes
Moazzen, H., Lu, X., Ma, N. L., Velenosi, T. J., Urquhart, B. L., Wisse, L. J., Gittenberger-de Groot, A. C., & Feng, Q. (2014) · Cardiovascular Diabetology · doi:10.1186/1475-2840-13-46 · Cited by 111
Hudson, C. D., Morris, P. J., Latchman, D. S., & Budhram-Mahadeo, V. S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m408679200 · Cited by 68
Programming of adult cardiovascular disease following exposure to late-gestation hyperglycemia
Agoudemos, M., Reinking, B. E., Koppenhafer, S. L., Segar, J. L., & Scholz, T. D. (2011) · Neonatology · doi:10.1159/000324863 · Cited by 27
Research works printed but not linked: 40
- Tang, 2015, Protective effect of sRAGE on fetal development in pregnant rats with gestational diabetes mellitus, Cell Biochem. Biophys., 71, 549, 10.1007/s12013-014-0233-9 · DOI
- Imam, 2012, Gestational diabetes mellitus, Adv. Exp. Med. Biol., 771, 24, 10.1007/978-1-4614-5441-0_4 · DOI
- Metzger, 2008, Hyperglycemia and adverse pregnancy outcomes, N. Engl. J. Med., 358, 1991, 10.1056/NEJMoa0707943 · DOI · Paper page
- Simeoni, 2009, Offspring of diabetic pregnancy: long-term outcomes, Semin. Fetal Neonatal Med., 14, 119, 10.1016/j.siny.2009.01.002 · DOI · Paper page
- Zhao, 2010, Cardiac malformations and alteration of TGFb signaling system in diabetic embryopathy, Birth Defects Res., 89, 97, 10.1002/bdrb.20225 · DOI
- Correa, 2008, Diabetes mellitus and birth defects, Am. J. Obstet. Gynecol., 199, 231
- Reece, 1996, The pathogenesis of diabetes-associated congenital malformations, Obstet. Gynecol. Clin. N. Am., 23, 29, 10.1016/S0889-8545(05)70243-6 · DOI
- Wren, 2003, Cardiovascular malformations in infants of diabetic mothers, Heart, 89, 1217, 10.1136/heart.89.10.1217 · DOI · Paper page
- Zhao, 2005, Experimental mechanisms of diabetic embryopathy and strategies for developing therapeutic interventions, J. Soc. Gynecol. Investig., 12, 549, 10.1016/j.jsgi.2005.07.005 · DOI
- Loeken, 2004, Free radicals and birth defects, J. Matern Fetal Neonatal Med., 15, 6, 10.1080/14767050310001650662 · DOI
- Bohuslavova, 2013, Increased susceptibility of HIF-1α heterozygous-null mice to cardiovascular malformations associated with maternal diabetes, J. Mol. Cell. Cardiol., 60, 129, 10.1016/j.yjmcc.2013.04.015 · DOI
- Gutierrez, 2009, Late-gestation ventricular myocardial reduction in fetuses of hyperglycemic CD1 mice is associated with increased apoptosis, Birth Defects Res. B Dev Reprod. Toxicol., 86, 409, 10.1002/bdrb.20212 · DOI
- Shi, 2010, ROCK1 plays an essential role in the transition from cardiac hypertrophy to failure in mice, J. Mol. Cell. Cardiol., 49, 819, 10.1016/j.yjmcc.2010.08.008 · DOI
- Majid, 2012, MicroRNA-1280 inhibits invasion and metastasis by targeting ROCK1 in bladder cancer, PLoS ONE, 7, 46743, 10.1371/journal.pone.0046743 · DOI
- Chang, 2006, Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis, Proc. Natl. Acad. Sci. U. S. A., 103, 14495, 10.1073/pnas.0601911103 · DOI · Paper page
- Zhang, 2006, Targeted deletion of ROCK1 protects the heart against pressure overload by inhibiting reactive fibrosis, FASEB J., 20, 916, 10.1096/fj.05-5129com · DOI · Paper page
- Shi, 2008, Disruption of ROCK1 gene attenuates cardiac dilation and improves contractile function in pathological cardiac hypertrophy, J. Mol. Cell. Cardiol., 44, 551, 10.1016/j.yjmcc.2007.11.018 · DOI
- Rikitake, 2005, Decreased perivascular fibrosis but not cardiac hypertrophy in ROCK1+/− haploinsufficient mice, Circulation, 112, 2959, 10.1161/CIRCULATIONAHA.105.584623 · DOI · Paper page
- Zheng, 2011, MicroRNA-148a suppresses tumor cell invasion and metastasis by downregulating ROCK1 in gastric cancer, Clin. Cancer Res., 17, 7574, 10.1158/1078-0432.CCR-11-1714 · DOI · Paper page
- Zhang, 2011, DNMT3a plays a role in switches between doxorubicin-induced senescence and apoptosis of colorectal cancer cells, Int. J. Cancer, 128, 551, 10.1002/ijc.25365 · DOI
- Michaelis, 2011, Identification of growth arrest and DNA-damage-inducible gene beta (GADD45beta) as a novel tumor suppressor in pituitary gonadotrope tumors, Endocrinology, 152, 3603, 10.1210/en.2011-0109 · DOI
- Su, 2013, Down-regulation of EBAF in the heart with ventricular septal defects and its regulation by histone acetyltransferase p300 and transcription factors smad2 and cited2, Biochim. Biophys. Acta, 1832, 2145, 10.1016/j.bbadis.2013.07.013 · doi:10.1016/j.bbadis.2013.07.013
- Liebig, 2009, RhoE Is required for keratinocyte differentiation and stratification, Mol. Biol. Cell, 20, 452, 10.1091/mbc.e07-11-1197 · DOI
- Su, 2009, BMP4-Smad signaling pathway mediates adriamycin-induced premature senescence in lung cancer cells, J. Biol. Chem., 284, 12153, 10.1074/jbc.M807930200 · DOI
- Nikiforov, 2007, Tumor cell-selective regulation of NOXA by c-MYC in response to proteasome inhibition, Proc. Natl. Acad. Sci. U. S. A., 104, 19488, 10.1073/pnas.0708380104 · DOI · Paper page
- Huskey, 2015, CDK1 inhibition targets the p53-NOXA-MCL1 axis, selectively kills embryonic stem cells, and prevents teratoma formation, Stem Cell Rep., 4, 374, 10.1016/j.stemcr.2015.01.019 · DOI
- Kim, 2004, BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1alpha, J. Exp. Med., 199, 113, 10.1084/jem.20030613 · DOI · Paper page
- Hershko, 2004, Up-regulation of Bcl-2 homology 3 (BH3)-only proteins by E2F1 mediates apoptosis, J. Biol. Chem., 279, 8627, 10.1074/jbc.M312866200 · DOI · Paper page
- Croft, 2011, p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival, Cell Res., 21, 666, 10.1038/cr.2010.154 · DOI
- Herraiz, 2015, Reactivation of p53 by a cytoskeletal sensor to control the balance between DNA damage and tumor dissemination, Nat. Cancer Inst., 108, djv289, 10.1093/jnci/djv289 · DOI · Paper page
- Oda, 2000, Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis, Science, 288, 1053, 10.1126/science.288.5468.1053 · DOI · Paper page
- Vijaya, 2013, Differential gene expression profiles during embryonic heart development in diabetic mice pregnancy, Gene, 516, 218, 10.1016/j.gene.2012.12.071 · DOI
- Kubbutat, 1997, Regulation of p53 stability by Mdm2, Nature, 387, 299, 10.1038/387299a0 · DOI · Paper page
- Xu, 2012, PDCD5 interacts with p53 and functions as a positive regulator in the p53 pathway, Apoptosis, 17, 1235, 10.1007/s10495-012-0754-x · DOI
- Seong, 2012, Murine protein serine-threonine kinase 38 activates p53 function through Ser15 phosphorylation, J. Biol. Chem., 287, 20797, 10.1074/jbc.M112.347757 · DOI
- Vemula, 2012, ROCK1 functions as a critical regulator of stress erythropoiesis and survival by regulating p53, Blood, 120, 2868, 10.1182/blood-2011-10-384172 · DOI
- Chouinard, 2002, UVB-mediated activation of p38 mitogen-activated protein kinase enhances resistance of normal human keratinocytes to apoptosis by stabilizing cytoplasmic p53, Biochem. J., 365, 133, 10.1042/bj20020072 · DOI
- Scolnick, 1997, CREB-binding protein and p300/CBP-associated factor are transcriptional coactivators of the p53 tumor suppressor protein, Cancer Res., 57, 3693
- Shi, 2016, Negative regulation of the p300-p53 interplay by DDX24, Oncogene, 35, 528, 10.1038/onc.2015.77 · DOI
- Kawasaki, 1998, Distinct roles of the co-activators p300 and CBP in retinoic-acid-induced F9-cell differentiation, Nature, 393, 284, 10.1038/30538 · DOI · Paper page
Cited by
p53: from understanding its structure to advances in therapeutic targeting
Wang, W., Liu, X., Liu, H., Abolhassani, H., Yan, H., Zhang, H., & Wang, X. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02549-5 · Cited by 30
Metadata
- Authors
- Su, D., Guan, L., Gao, Q., Li, Q., Shi, C., Liu, Y., Sun, L., Lu, C., Ma, X., & Zhao, J.
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Publisher
- Elsevier BV
- Published
- 2017-04
- Volume
- 1863
- Issue
- 4
- Pages
- 936-946
- ISSN
- 0925-4439
- Cited by
- 23
- References
- 5
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 365 d)
- Funders
- National Natural Science Foundation of China (31301145)
- Central Public-Interest Scientific Institution Basal Research Fund (2016GJSSJKA02)
- National Key Research and Development Program of China (2016 YFC1000300, YFC1000307)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: ROCK1/p53/NOXA signaling mediates cardiomyocyte apoptosis in response to high glucose in vitro and vivo. https://app.cochat.ai/papers/10.1016/j.bbadis.2017.01.021
- The paper
- Su, D., Guan, L., Gao, Q., Li, Q., Shi, C., Liu, Y., Sun, L., Lu, C., Ma, X., & Zhao, J. (2017). ROCK1/p53/NOXA signaling mediates cardiomyocyte apoptosis in response to high glucose in vitro and vivo. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. https://doi.org/10.1016/j.bbadis.2017.01.021
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.