The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Circulating cell-free mitochondrial DNA levels correlate with body mass index and age
Open accessOverview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Assessing presence of extracellular mitochondria or their fragments by measuring ccf-mtDNA levels could allow on-flight direct estimation of cellular stress to take preventive measures of cumulative damage.
“Assessing the presence of extracellular mitochondria or their fragments by measuring ccf-mtDNA levels could allow on-flight direct estimation of cellular stress to take preventive measures of cumulative damage196,199–206.”
From Key points for the development of antioxidant cocktails to prevent cellular stress and damage caused by reactive oxygen species (ROS) during manned space missions (2021) · cites this paper as [199]
The Abstract says mitochondria or their fragments can be released during stress and that ccf-mtDNA can be measured in serum as a possible biomarker. It does not establish that measuring ccf-mtDNA permits direct, on-flight estimation of cellular stress or enables preventive measures against cumulative damage. (LLM, conf=0.86)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Activation of apoptosis signalling pathways by reactive oxygen species
Redza-Dutordoir, M., & Averill-Bates, D. A. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2016.09.012 · Cited by 3,731
Du, X. L., Edelstein, D., Dimmeler, S., Ju, Q., Sui, C., & Brownlee, M. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11235 · Cited by 907
Pinti, M., Cevenini, E., Nasi, M., De Biasi, S., Salvioli, S., Monti, D., Benatti, S., Gibellini, L., Cotichini, R., Stazi, M. A., et al. (2014) · European Journal of Immunology · doi:10.1002/eji.201343921 · Cited by 409
Forms of extracellular mitochondria and their impact in health
Miliotis, S., Nicolalde, B., Ortega, M., Yepez, J., & Caicedo, A. (2019) · Mitochondrion · doi:10.1016/j.mito.2019.02.002 · Cited by 138
Self-citation
Flagged first, then by citations
Research works printed but not linked: 12
- De Martinis, 2006, Inflammation markers predicting frailty and mortality in the elderly, Exp. Mol. Pathol., 80, 219, 10.1016/j.yexmp.2005.11.004 · DOI
- Franceschi, 2000, Inflamm-aging. An evolutionary perspective on immunosenescence, Ann. N. Y. Acad. Sci., 908, 244, 10.1111/j.1749-6632.2000.tb06651.x · DOI · Paper page
- Skuratovskaia, 2018, Additional evidence of the link between mtDNA copy number and the body mass index, Mitochondrial DNA A DNA Mapp. Seq. Anal., 29, 1240
- Mozhey, 2014, Evaluating the number of mitochondrial DNA copies in leukocytes and adipocytes from metabolic syndrome patients: pilot study, Mol. Biol., 48, 590, 10.1134/S0026893314040074 · DOI
- Padilla, 2017, Circulating mtDNA levels as an early marker for metabolic syndrome, Free Radic. Biol. Med., 108, S73, 10.1016/j.freeradbiomed.2017.04.249 · DOI
- Lee, 2014, Mitochondrial DNA copy number in peripheral blood is independently associated with visceral fat accumulation in healthy young adults, Int. J. Endocrinol., 2014, 1
- Cabrera, 2019, Primary allogeneic mitochondrial mix (PAMM) transfer/transplant by MitoCeption to address damage in PBMCs caused by ultraviolet radiation, BMC Biotechnol., 19, 42, 10.1186/s12896-019-0534-6 · DOI
- Srinivasan, 2003, Glucose regulates monocyte adhesion through endothelial production of interleukin-8, Circ. Res., 92, 371, 10.1161/01.RES.0000061714.74668.5C · DOI
- Simoes, 2018, Mitochondria innon-alcoholic fatty liver disease, Int. J. Biochem. Cell Biol., 95, 93, 10.1016/j.biocel.2017.12.019 · DOI · Paper page
- Heitzer, 2001, Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease, Circulation, 104, 2673, 10.1161/hc4601.099485 · DOI · Paper page
- Matsuda, 2013, Increased oxidative stress in obesity: implications for metabolic syndrome, diabetes, hypertension, dyslipidemia, atherosclerosis, and cancer, Obes. Res. Clin. Pract., 7, e330, 10.1016/j.orcp.2013.05.004 · DOI
- Song, 2020, High-altitude chronic hypoxia ameliorates obesity-induced non-alcoholic fatty liver disease in mice by regulating mitochondrial and AMPK signaling, Life Sci., 252, 117633, 10.1016/j.lfs.2020.117633 · DOI
Cited by
Sorted by citations
Gómez, X., Sanon, S., Zambrano, K., Asquel, S., Bassantes, M., Morales, J. E., Otáñez, G., Pomaquero, C., Villarroel, S., Zurita, A., et al. (2021) · npj Microgravity · doi:10.1038/s41526-021-00162-8 · Cited by 92
Self-citation
Metadata
- Authors
- Padilla-Sánchez, S. D., Navarrete, D., Caicedo, A., & Teran, E.
- Affiliations
- Universidad San Francisco de Quito (EC)
- Corresponding author
- Caicedo, Andrés
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Publisher
- Elsevier BV
- Published
- 2020-12
- Volume
- 1866
- Issue
- 12
- Pages
- 165963
- ISSN
- 0925-4439 (ISSN-L)
- OpenAlex
- W3084895298
- Cited by
- 36
- References
- 4
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 8 · 2023: 7 · 2022: 3 · 2021: 5
- FWCI
- 1.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Universidad San Francisco de Quito (HUBI 5637)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- circulating cell-free mitochondrial DNA, mtDNA release, body mass index, aging, age-related frailty, metabolic disorders, biomarkers, sex differences
- MeSH terms
- Adult, Age Factors, Aged, Blood Glucose, DNA, Mitochondrial, Fasting, Female, Humans, Male, Middle Aged, Body Mass Index, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
