Endothelial Dysfunction, Oxidative Stress, and Risk of Cardiovascular Events in Patients With Coronary Artery Disease
Abstract
Background Endothelial function is impaired in coronary artery disease and may contribute to its clinical manifestations. Increased oxidative stress has been linked to impaired endothelial function in atherosclerosis and may play a role in the pathogenesis of cardiovascular events. This study was designed to determine whether endothelial dysfunction and vascular oxidative stress have prognostic impact on cardiovascular event rates in patients with coronary artery disease. Methods and Results Endothelium-dependent and -independent vasodilation was determined in 281 patients with documented coronary artery disease by measuring forearm blood flow responses to acetylcholine and sodium nitroprusside using venous occlusion plethysmography. The effect of the coadministration of vitamin C (24 mg/min) was assessed in a subgroup of 179 patients. Cardiovascular events, including death from cardiovascular causes, myocardial infarction, ischemic stroke, coronary angioplasty, and coronary or peripheral bypass operation, were studied during a mean follow-up period of 4.5 years. Patients experiencing cardiovascular events (n=91) had lower vasodilator responses to acetylcholine ( P <0.001) and sodium nitroprusside ( P <0.05), but greater benefit from vitamin C ( P <0.01). The Cox proportional regression analysis for conventional risk factors demonstrated that blunted acetylcholine-induced vasodilation ( P =0.001), the effect of vitamin C ( P =0.001), and age ( P =0.016) remained independent predictors of cardiovascular events. Conclusions Endothelial dysfunction and increased vascular oxidative stress predict the risk of cardiovascular events in patients with coronary artery disease. These data support the concept that oxidative stress may contribute not only to endothelial dysfunction but also to coronary artery disease activity.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Endothelial dysfunction occurs early in the pathogenesis of atherosclerosis, and predicts future cardiovascular events.
“Endothelial dysfunction occurs early in the pathogenesis of atherosclerosis, and predicts future cardiovascular events.”
From The Vasculature in Prediabetes (2018) · cites this paper as [31]
Cites
(2000) · New England Journal of Medicine · doi:10.1056/nejm200001203420301 · Cited by 8,663 · see citing works
Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress
Cai, H., & Harrison, D. G. (2000) · Circulation Research · doi:10.1161/01.res.87.10.840 · Cited by 3,839 · see citing works
Schächinger, V., Britten, M. B., & Zeiher, A. M. (2000) · Circulation · doi:10.1161/01.cir.101.16.1899 · Cited by 2,584 · see citing works
Vitamin E Consumption and the Risk of Coronary Heart Disease in Men
Rimm, E. B., Stampfer, M. J., Ascherio, A., Giovannucci, E. L., Colditz, G. A., & Willett, W. C. (1993) · New England Journal of Medicine · doi:10.1056/nejm199305203282004 · Cited by 2,335 · see citing works
Long-Term Follow-Up of Patients With Mild Coronary Artery Disease and Endothelial Dysfunction
Suwaidi, J. M. S. A., Hamasaki, S., Higano, S. T., Nishimura, R. A., Holmes, D. R., & Lerman, A. (2000) · Circulation · doi:10.1161/01.cir.101.9.948 · Cited by 2,044 · see citing works
Close Relation of Endothelial Function in the Human Coronary and Peripheral Circulations
Anderson, T. J., Uehata, A., Gerhard, M. D., Meredith, I. T., Knab, S., Delagrange, D., Lieberman, E. H., Ganz, P., Creager, M. A., Yeung, A. C., et al. (1995) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(95)00327-4 · Cited by 2,033 · cited 1× · see citing works
“Diabetes mellitus, n (%) 57 (21) 20 (22) 37 (20)”
Ascorbate is an outstanding antioxidant in human blood plasma
Frei, B., England, L., & Ames, B. N. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.16.6377 · Cited by 1,870 · see citing works
Hypercholesterolemia increases endothelial superoxide anion production.
Ohara, Y., Peterson, T. E., & Harrison, D. G. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116491 · Cited by 1,765 · see citing works
Effect of Exercise on Coronary Endothelial Function in Patients with Coronary Artery Disease
Hambrecht, R., Wolf, A., Gielen, S., Linke, A., Hofer, J., Erbs, S., Schoene, N., & Schuler, G. (2000) · New England Journal of Medicine · doi:10.1056/nejm200002173420702 · Cited by 1,340 · see citing works
Treasure, C. B., Klein, J., Weintraub, W. S., Talley, J., Stillabower, M., Kosinski, A. S., Zhang, J., Boccuzzi, S., Cedarholm, J. C., & Alexander, R. (1995) · New England Journal of Medicine · doi:10.1056/nejm199502233320801 · Cited by 1,335 · see citing works
Anderson, T. J., Meredith, I. T., Yeung, A. C., Frei, B. B., Selwyn, A. P., & Ganz, P. (1995) · New England Journal of Medicine · doi:10.1056/nejm199502233320802 · Cited by 1,108 · see citing works
&NA; (1996) · Journal of Occupational and Environmental Medicine · doi:10.1097/00043764-199605000-00005 · Cited by 1,070 · see citing works
Mancini, G. B. J., Henry, G. C., Macaya, C., O’Neill, B. J., Pucillo, A. L., Carere, R. G., Wargovich, T. J., Mudra, H. G., Lüscher, T. F., Klibaner, M. I., et al. (1996) · Circulation · doi:10.1161/01.cir.94.3.258 · Cited by 1,056 · see citing works
Dietary Antioxidant Vitamins and Death from Coronary Heart Disease in Postmenopausal Women
Kushi, L. H., Folsom, A. R., Prineas, R. J., Mink, P. J., Wu, Y. G., & Bostick, R. M. (1996) · New England Journal of Medicine · doi:10.1056/nejm199605023341803 · Cited by 959 · see citing works
Fichtlscherer, S., Rosenberger, G., Walter, D. H., Breuer, S., Dimmeler, S., & Zeiher, A. M. (2000) · Circulation · doi:10.1161/01.cir.102.9.1000 · Cited by 665 · see citing works
Physical Training Improves Endothelial Function in Patients With Chronic Heart Failure
Hornig, B., Maier, V., & Drexler, H. (1996) · Circulation · doi:10.1161/01.cir.93.2.210 · Cited by 628 · see citing works
Miller, F. J., Gutterman, D. D., Rios, C., Heistad, D. D., & Davidson, B. L. (1998) · Circulation Research · doi:10.1161/01.res.82.12.1298 · Cited by 623 · see citing works
Acute Systemic Inflammation Impairs Endothelium-Dependent Dilatation in Humans
Hingorani, A. D., Cross, J. M., Kharbanda, R. K., Mullen, M. J., Bhagat, K., Taylor, M., Donald, A. E., Palacios‐Callender, M., Griffin, G. E., Deanfield, J. E., et al. (2000) · Circulation · doi:10.1161/01.cir.102.9.994 · Cited by 605 · see citing works
Vascular Superoxide Production by NAD(P)H Oxidase
Guzik, T. J., West, N. E. J., Black, E., McDonald, D., Ratnatunga, C., Pillai, R. G., & Channon, K. M. (2000) · Circulation Research · doi:10.1161/01.res.86.9.e85 · Cited by 584 · see citing works
Ascorbic Acid Reverses Endothelial Vasomotor Dysfunction in Patients With Coronary Artery Disease
Levine, G. N., Frei, B., Koulouris, S. N., Gerhard, M. D., Keaney, J. F., & Vita, J. A. (1996) · Circulation · doi:10.1161/01.cir.93.6.1107 · Cited by 582 · see citing works
Vitamin C Intake and Mortality among a Sample of the United States Population
Enstrom, J., Kanim, L., & Klein, M. A. (1992) · Epidemiology · doi:10.1097/00001648-199205000-00003 · Cited by 580 · see citing works
Antioxidant Vitamin C Improves Endothelial Dysfunction in Chronic Smokers
Heitzer, T., Just, H., & Mu¨nzel, T. (1996) · Circulation · doi:10.1161/01.cir.94.1.6 · Cited by 554 · see citing works
Self-citationLate prognostic value of flow-mediated dilation in the brachial artery of patients with chest pain
Neunteufl, T., Heher, S., Katzenschlager, R., Wölfl, G., Kostner, K., Maurer, G., & Weidinger, F. (2000) · The American Journal of Cardiology · doi:10.1016/s0002-9149(00)00857-2 · Cited by 553 · see citing works
Systemic endothelial dysfunction is related to the extent and severity of coronary artery disease
Neunteufl, T., Katzenschlager, R., Hassan, A. H. M., Klaar, U., Schwarzacher, S. P., Glogar, D., Bauer, P., & Weidinger, F. F. (1997) · Atherosclerosis · doi:10.1016/s0021-9150(96)06018-2 · Cited by 510 · see citing works
Jackson, T. S., Xu, A., Vita, J. A., & Keaney, J. F. (1998) · Circulation Research · doi:10.1161/01.res.83.9.916 · Cited by 400 · cited 1× · see citing works
“Diabetes mellitus, n (%) 57 (21) 20 (22) 37 (20)”
Stroes, E. S. G., Koomans, H. A., Rabelink, T. J., & de Bruin, T. W. (1995) · The Lancet · doi:10.1016/s0140-6736(95)91322-x · Cited by 390 · see citing works
Gokce, N., Keaney, J. F., Frei, B., Holbrook, M., Olesiak, M., Zachariah, B. J., Leeuwenburgh, C., Heinecke, J. W., & Vita, J. A. (1999) · Circulation · doi:10.1161/01.cir.99.25.3234 · Cited by 387 · see citing works
Ting, H. H., Timimi, F. K., Haley, E. A., Roddy, M.-A., Ganz, P., & Creager, M. A. (1997) · Circulation · doi:10.1161/01.cir.95.12.2617 · Cited by 355 · see citing works
Endothelial dysfunction: Clinical implications
Drexler, H. (1997) · Progress in Cardiovascular Diseases · doi:10.1016/s0033-0620(97)80030-8 · Cited by 291 · see citing works
Oelze, M. W., Mollnau, H., Hoffmann, N., Warnholtz, A., Bodenschatz, M., Smolenski, A., Walter, U., Skatchkov, M. P., Meinertz, T., & Münzel, T. F. (2000) · Circulation Research · doi:10.1161/01.res.87.11.999 · Cited by 253 · see citing works
Self-citationLiao, F., Andalibi, A., Qiao, J. H., et al. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117409 · Cited by 231 · see citing works
Mülsch, A., Bauersachs, J. K., Schäfer, A., Stasch, J., Kast, R., & Busse, R. (1997) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0700982 · Cited by 222 · see citing works
Keaney, J. F., & Vita, J. A. (1995) · Progress in Cardiovascular Diseases · doi:10.1016/s0033-0620(05)80003-9 · Cited by 195 · see citing works
Heitzer, T. A., Ylä‐Herttuala, S., Wild, E., Luoma, J., & Drexler, H. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)00584-1 · Cited by 126 · see citing works
Self-citationHuraux, C., Makita, T., Kurz, S. K., Yamaguchi, K., Szlam, F., Tarpey, M. M., Wilcox, J. N., Harrison, D. G., & Levy, J. H. (1999) · Circulation · doi:10.1161/01.cir.99.1.53 · Cited by 95 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Role of Endothelial Dysfunction in Atherosclerosis
Davignon, J., & Ganz, P. (2004) · Circulation · doi:10.1161/01.cir.0000131515.03336.f8 · Cited by 2,513 · see citing works
Endothelial Nitric Oxide Synthase in Vascular Disease: From Marvel to Menace
Förstermann, U., & Münzel, T. (2006) · Circulation · doi:10.1161/circulationaha.105.602532 · Cited by 1,957 · see citing works
The clinical implications of endothelial dysfunction
Widlansky, M. E., Gokce, N., Keaney, J. F., & Vita, J. A. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00994-x · Cited by 1,749 · see citing works
Chiasson, J.-L., Josse, R. G., Gomis, R., Hanefeld, M., Karasik, A., Laakso, M., & for The STOP-NIDDM Trial Research Group (2003) · JAMA · doi:10.1001/jama.290.4.486 · Cited by 1,624 · see citing works
Ceriello, A., & Motz, E. (2004) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000122852.22604.78 · Cited by 1,378 · see citing works
Effect of exercise training on endothelium‐derived nitric oxide function in humans
Green, D. J., Maiorana, A., O'Driscoll, G., & Taylor, R. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.068197 · Cited by 1,040 · see citing works
Superoxide Production and Expression of Nox Family Proteins in Human Atherosclerosis
Sorescu, D., Weiss, D., Lassègue, B., Clempus, R. E., Szöcs, K., Sorescu, G. P., Valppu, L., Quinn, M. T., Lambeth, J. D., Vega, J. D., et al. (2002) · Circulation · doi:10.1161/01.cir.0000012917.74432.66 · Cited by 847 · see citing works
Endothelial Function: A Critical Determinant in Atherosclerosis?
Landmesser, U., Hornig, B., & Drexler, H. (2004) · Circulation · doi:10.1161/01.cir.0000129501.88485.1f · Cited by 851 · see citing works
Joyner, M. J., & Casey, D. P. (2015) · Physiological Reviews · doi:10.1152/physrev.00035.2013 · Cited by 833 · see citing works
Aging and vascular endothelial function in humans
Seals, D. R., Jablonski, K. L., & Donato, A. J. (2011) · Clinical Science · doi:10.1042/cs20100476 · Cited by 725 · see citing works
Oxidative stress in vascular disease: causes, defense mechanisms and potential therapies
Förstermann, U. (2008) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio1211 · Cited by 576 · see citing works
Targeting vascular (endothelial) dysfunction
Daiber, A., Steven, S., Weber, A., Shuvaev, V. V., Muzykantov, V. R., Laher, I., Li, H., Lamas, S., & Münzel, T. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13517 · Cited by 501 · see citing works
Allopurinol Improves Endothelial Dysfunction in Chronic Heart Failure
Farquharson, C. A. J., Butler, R., Hill, A., Belch, J. J. F., & Struthers, A. D. (2002) · Circulation · doi:10.1161/01.cir.0000022140.61460.1d · Cited by 504 · see citing works
Is oxidative stress a therapeutic target in cardiovascular disease?
Münzel, T., Gori, T., Bruno, R. M., & Taddei, S. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq396 · Cited by 470 · see citing works
Self-citationVitamin C: Update on physiology and pharmacology
Mandl, J., Szarka, A., & Bánhegyi, G. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00282.x · Cited by 451 · see citing works
Taddei, S., Caraccio, N., Virdis, A., Dardano, A., Versari, D., Ghiadoni, L., Salvetti, A., Ferrannini, E., & Monzani, F. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030039 · Cited by 431 · see citing works
Nitric oxide, tetrahydrobiopterin, oxidative stress, and endothelial dysfunction in hypertension
Schulz, E., Jansen, T., Wenzel, P., Daiber, A., & Münzel, T. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1989 · Cited by 430 · see citing works
Explaining the Phenomenon of Nitrate Tolerance
Münzel, T., Daiber, A., & Mülsch, A. (2005) · Circulation Research · doi:10.1161/01.res.0000184694.03262.6d · Cited by 424 · see citing works
Self-citationPicciotto, N. E., Gano, L. B., Johnson, L. C., Martens, C. R., Sindler, A. L., Mills, K. F., Imai, S., & Seals, D. R. (2016) · Aging Cell · doi:10.1111/acel.12461 · Cited by 396 · see citing works
Plasma nitrite concentrations reflect the degree of endothelial dysfunction in humans
Kleinbongard, P., Dejam, A., Lauer, T., Jax, T., Kerber, S., Gharini, P., Balzer, J., Zotz, R. B., Scharf, R. E., Willers, R., et al. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.08.025 · Cited by 388 · see citing works
Thomas, S. R., Witting, P. K., & Drummond, G. R. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2008.2027 · Cited by 383 · see citing works
Amar, S., Gokce, N., Morgan, S., Loukideli, M., Van Dyke, T. E., & Vita, J. A. (2003) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000078603.90302.4a · Cited by 361 · see citing works
Role of Vitamin C in the Function of the Vascular Endothelium
May, J. M., & Harrison, F. E. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5205 · Cited by 358 · see citing works
Münzel, T., Feil, R., Mülsch, A., Lohmann, S. M., Hofmann, F., & Walter, U. (2003) · Circulation · doi:10.1161/01.cir.0000094403.78467.c3 · Cited by 316 · see citing works
eNOS Uncoupling in Cardiovascular Diseases - the Role of Oxidative Stress and Inflammation
Karbach, S., Wenzel, P., Waisman, A., Munzel, T., & Daiber, A. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113196660748 · Cited by 307 · see citing works
Public health and components of particulate matter: The changing assessment of black carbon
Grahame, T. J., Klemm, R., & Schlesinger, R. B. (2014) · Journal of the Air & Waste Management Association · doi:10.1080/10962247.2014.912692 · Cited by 294 · see citing works
Sydow, K., Daiber, A., Oelze, M., Chen, Z., August, M., Wendt, M., Ullrich, V., Mülsch, A., Schulz, E., Keaney, J. F., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200419267 · Cited by 300 · see citing works
Self-citationScioli, M. G., Storti, G., D’Amico, F., Rodríguez Guzmán, R., Centofanti, F., Doldo, E., Céspedes Miranda, E. M., & Orlandi, A. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9061995 · Cited by 281 · see citing works
Coronary Artery Superoxide Production and Nox Isoform Expression in Human Coronary Artery Disease
Guzik, T. J., Sadowski, J., Guzik, B., Jopek, A., Kapelak, B., Przybyłowski, P., Wierzbicki, K., Korbut, R., Harrison, D. G., & Channon, K. M. (2006) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000196651.64776.51 · Cited by 278 · see citing works
Engler, M. M., Engler, M. B., Malloy, M. J., Chiu, E. Y., Schloetter, M. C., Paul, S. M., Stuehlinger, M., Lin, K. Y., Cooke, J. P., Morrow, J. D., et al. (2003) · Circulation · doi:10.1161/01.cir.0000086345.09861.a0 · Cited by 253 · see citing works
Lee, D. M., Battson, M. L., Jarrell, D. K., Hou, S., Ecton, K. E., Weir, T. L., & Gentile, C. L. (2018) · Cardiovascular Diabetology · doi:10.1186/s12933-018-0708-x · Cited by 246 · see citing works
“Similar to aPWV and EDD, vascular smooth muscle dysfunction, as determined by reductions in EID, is common in T2D and predicts cardiovascular complications and mortality [16, 17].”
BackgroundEndothelial dysfunction and coronary artery disease: assessment, prognosis, and treatment
Matsuzawa, Y., & Lerman, A. (2014) · Coronary Artery Disease · doi:10.1097/mca.0000000000000178 · Cited by 249 · see citing works
Kowluru, R. A., & Odenbach, S. (2004) · Diabetes · doi:10.2337/diabetes.53.12.3233 · Cited by 227 · see citing works
Shimbo, D., Grahame-Clarke, C., Miyake, Y., Rodriguez, C., Sciacca, R., Di Tullio, M., Boden-Albala, B., Sacco, R., & Homma, S. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.05.005 · Cited by 219 · see citing works
New insights into the role of adipose tissue in thrombosis
Vilahur, G., Ben-Aicha, S., & Badimon, L. (2017) · Cardiovascular Research · doi:10.1093/cvr/cvx086 · Cited by 216 · see citing works
Crabtree, M. J., Smith, C. L., Lam, G., Goligorsky, M. S., & Gross, S. S. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00823.2007 · Cited by 213 · see citing works
Landmesser, U., Spiekermann, S., Preuss, C., Sorrentino, S., Fischer, D., Manes, C., Mueller, M., & Drexler, H. (2007) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000258415.32883.bf · Cited by 210 · see citing works
Arterial stiffness or endothelial dysfunction as a surrogate marker of vascular risk
Anderson, T. J. (2006) · Canadian Journal of Cardiology · doi:10.1016/s0828-282x(06)70990-4 · Cited by 178 · see citing works
Wassmann, S., Faul, A., Hennen, B., Scheller, B., Böhm, M., & Nickenig, G. (2003) · Circulation Research · doi:10.1161/01.res.0000099503.13312.7b · Cited by 177 · see citing works
Acute adenosinergic cardioprotection in ischemic-reperfused hearts.
Headrick, J. P., Hack, B., & Ashton, K. J. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00407.2003 · Cited by 171 · see citing works
A Review of Dietary Phytochemicals and Their Relation to Oxidative Stress and Human Diseases
Guan, R., Van Le, Q., Yang, H., Zhang, D., Gu, H., Yang, Y., Sonne, C., Lam, S. S., Zhong, J., Jianguang, Z., et al. (2021) · Chemosphere · doi:10.1016/j.chemosphere.2020.129499 · Cited by 169 · see citing works
Higgins, P., Dawson, J., Lees, K. R., McArthur, K., Quinn, T. J., & Walters, M. R. (2012) · Cardiovascular Therapeutics · doi:10.1111/j.1755-5922.2011.00277.x · Cited by 164 · see citing works
The Vasculature in Prediabetes
Wasserman, D. H., Wang, T. J., & Brown, N. J. (2018) · Circulation Research · doi:10.1161/circresaha.118.311912 · Cited by 137 · see citing works
Senger, D. R., Li, D., Jaminet, S.-C., & Cao, S. (2016) · PLOS ONE · doi:10.1371/journal.pone.0148042 · Cited by 124 · see citing works
Relatively high mortality risk in elderly Swedish subjects with low selenium status
Alehagen, U., Johansson, P., Björnstedt, M., Rosén, A., Post, C., & Aaseth, J. (2016) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2015.92 · Cited by 95 · see citing works
Sawada, T., Tsubata, H., Hashimoto, N., Takabe, M., Miyata, T., Aoki, K., Yamashita, S., Oishi, S., Osue, T., Yokoi, K., et al. (2016) · Cardiovascular Diabetology · doi:10.1186/s12933-016-0437-y · Cited by 97 · see citing works
Stenvinkel, P. (2002) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/17.suppl_5.32 · Cited by 97 · see citing works
Can Metformin Exert as an Active Drug on Endothelial Dysfunction in Diabetic Subjects
Salvatore, T., Pafundi, P. C., Galiero, R., Rinaldi, L., Caturano, A., Vetrano, E., Aprea, C., Albanese, G., Di Martino, A., Ricozzi, C., et al. (2020) · Biomedicines · doi:10.3390/biomedicines9010003 · Cited by 97 · see citing works
Pannirselvam, M., Simon, V., Verma, S., Anderson, T., & Triggle, C. R. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705476 · Cited by 91 · see citing works
Myocardial protection by nitrite
Calvert, J. W., & Lefer, D. J. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp079 · Cited by 82 · see citing works
Relevance of Oxidative Pathways in the Pathophysiology of Chronic Kidney Disease
Himmelfarb, J. (2005) · Cardiology Clinics · doi:10.1016/j.ccl.2005.03.005 · Cited by 81 · see citing works
Oyama, J.-I., Maeda, T., Kouzuma, K., Ochiai, R., Tokimitsu, I., Higuchi, Y., Sugano, M., & Makino, N. (2010) · Circulation Journal · doi:10.1253/circj.cj-09-0692 · Cited by 73 · see citing works
Karnewar, S., Vasamsetti, S. B., Gopoju, R., Kanugula, A. K., Ganji, S. K., Prabhakar, S., Rangaraj, N., Tupperwar, N., Kumar, J. M., & Kotamraju, S. (2016) · Scientific Reports · doi:10.1038/srep24108 · Cited by 62 · see citing works
Robinson, S. D., Ludlam, C. A., Boon, N. A., & Newby, D. E. (2007) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.107.143248 · Cited by 62 · see citing works
Why the endothelium? The endothelium as a target to reduce diabetes-associated vascular disease
Triggle, C. R., Ding, H., Marei, I., Anderson, T. J., & Hollenberg, M. D. (2020) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2019-0677 · Cited by 49 · see citing works
Simvastatin Combined With Ramipril Treatment in Hypercholesterolemic Patients
Koh, K. K., Son, J. W., Ahn, J. Y., Kim, D. S., Jin, D. K., Kim, H. S., Han, S. H., Seo, Y.-H., Chung, W.-J., Kang, W. C., et al. (2004) · Hypertension · doi:10.1161/01.hyp.0000133310.42762.25 · Cited by 45 · see citing works
Sherwood, A., Blumenthal, J. A., Smith, P. J., Watkins, L. L., Hoffman, B. M., & Hinderliter, A. L. (2016) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000301 · Cited by 44 · see citing works
The relationship between plasma and salivary NOx
Clodfelter, W. H., Basu, S., Bolden, C., Dos Santos, P. C., King, S. B., & Kim-Shapiro, D. B. (2015) · Nitric Oxide · doi:10.1016/j.niox.2015.04.003 · Cited by 39 · see citing works
The assessment of vascular function during dietary intervention trials in human subjects
McCall, D. O., McKinley, M. C., Noad, R., McKeown, P. P., McCance, D. R., Young, I. S., & Woodside, J. V. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511002996 · Cited by 14 · see citing works
Sugur, K., Kempegowda, S. N., Shambu, S. K., Mahadevappa, M., Kengegowda, V. K., Gowda, J., & Thimmulappa, R. K. (2024) · Diabetes & Metabolic Syndrome: Clinical Research & Reviews · doi:10.1016/j.dsx.2024.103143 · Cited by 4 · see citing works
- Authors
- Heitzer, T., Schlinzig, T., Krohn, K., Meinertz, T., & Münzel, T.
- Affiliations
- University Medical Center Hamburg-Eppendorf (DE)
- From the Universitätsklinikum Hamburg-Eppendorf, Klinik und Poliklinik für Innere Medizin, Abteilung Kardiologie, Hamburg, Germany.
- ORCID
- Schlinzig, Titus
- Venue
- Circulation
- Published
- 2001-11-27
- Volume
- 104
- Issue
- 22
- Pages
- 2673-2678
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2083481797
- Cited by
- 1,961
- References
- 35
- Citations by year
- 2026: 24 · 2025: 35 · 2024: 53 · 2023: 41 · 2022: 42 · 2021: 77 · 2020: 83 · 2019: 82 · 2018: 83 · 2017: 71 · 2016: 83 · 2015: 104 · 2014: 95 · 2013: 77 · 2012: 102
- FWCI
- 46.23
- Type
- journal article
- Language
- en
- Update notices
- correction (2003-07-29)
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- endothelial dysfunction, oxidative stress, coronary artery disease, cardiovascular events, acetylcholine-induced vasodilation, sodium nitroprusside, vitamin C, forearm blood flow, venous occlusion plethysmography, cardiovascular risk prediction, myocardial infarction, ischemic stroke, atherosclerosis
- MeSH terms
- Antioxidants, Ascorbic Acid, Cardiovascular Diseases, Coronary Artery Disease, Dose-Response Relationship, Drug, Endothelium, Vascular, Female, Follow-Up Studies, Forearm, Humans, Male, Middle Aged, Plethysmography, Predictive Value of Tests, Prognosis, Prospective Studies, Regional Blood Flow, Vasodilation, Vasodilator Agents, Survival Rate, Proportional Hazards Models, Oxidative Stress, Disease Progression, Risk Assessment
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review