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Cited by 46

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

The effect of dietary sphingolipids on plasma sphingomyelin metabolism and atherosclerosis

Li, Zhiqiang, Basterr, Maria J., Hailemariam, Tiruneh K., Hojjati, Mohammad Reza, Lu, Shendi, Liu, Jin, Liu, Ruijie, Zhou, Hongwen, Jiang, Xian-Cheng·2005·Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
DOI 10.1016/j.bbalip.2005.05.004
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Abstract

Sphingomyelin (SM) plays a very important role in cell membrane formation and plasma lipoprotein metabolism. All these functions may have an impact on atherosclerotic development. To investigate the relationship between SM metabolism and atherosclerosis, we utilized a sphingolipid-rich diet to feed LDL receptor gene knockout (LDLr KO) mice and studied lipid metabolism and atherosclerosis in the mice. After 3 months of a sphingolipid-rich diet, we found a significant increase in SM, cholesterol, and SM/phosphatidylcholine (PC) ratio (50%, P<0.001; 62%, P<0.01; and 45%, P<0.01, respectively), compared to chow fed diet. HDL-lipids were not significantly altered. Non-HDL-SM, non-HDL-C, and non-HDL-SM/non-HDL-PC ratio were significantly increased (115%, P<0.001; 106%, P<0.001; and 106%, P<0.01, respectively). FPLC confirmed the results. SDS-PAGE showed an increase of apoB48 and apoB100, but no changes of apoAI. Moreover, we found that an SM-rich diet significantly increased atherosclerotic lesion area in both root assay and en face assay, compared to chow diet (58,210+/-15,300 microm(2) vs. 9670+/-2370 microm(2), P<0.001; 5.9+/-3.1% vs. 1.1+/-0.9%, P<0.001). These results indicate that the enrichment of sphingolipids in diet has proatherogenic properties.

Overview

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Crossref · 10.1016/j.bbalip.2005.05.004

Cites

33 of 33 references verified0 citation errors · 0 not checkable

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Metadata

Authors
Li, Z., Basterr, M. J., Hailemariam, T. K., Hojjati, M. R., Lu, S., Liu, J., Liu, R., Zhou, H., & Jiang, X.-C.
Venue
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Publisher
Elsevier BV
Published
2005-07
Volume
1735
Issue
2
Pages
130-134
ISSN
1388-1981
DOI
10.1016/j.bbalip.2005.05.004
Cited by
46
References
33
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.