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Cited by 102Alzheimer's disease research and treatmentsCholesterol and Lipid MetabolismDrug Transport and Resistance Mechanisms

The role of ATP-binding cassette transporter A1 in Alzheimer's disease and neurodegeneration

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Koldamova, Radosveta, Fitz, Nicholas F., Lefterov, Iliya·2010·Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
DOI 10.1016/j.bbalip.2010.02.010PMC PMC3712769
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Abstract

ATP-binding cassette transporter A1 - ABCA1, is the most extensively studied transporter in human pathology. ABCA1 became a primary subject of research in many academic and pharmaceutical laboratories immediately after the discovery that mutations at the gene locus cause severe familial High Density Lipoprotein (HDL) deficiency and, in the homozygous form - Tangier disease. The protein is the major regulator of intracellular cholesterol efflux which is the initial and essential step in the biogenesis and formation of nascent HDL particles. The transcriptional regulation of ABCA1 by nuclear Liver X Receptors (LXR) provided a starting point for drug discovery and development of synthetic LXR ligands/ABCA1 activators for treatment of arteriosclerosis. A series of reports that revealed the role of ABCA1 in Abeta deposition and clearance, as well as the possibility for association of some ABCA1 genetic variants with risk for Alzheimer's disease (AD) brought a new dimension to ABCA1 research. The LXR-ABCA1-APOE regulatory axis is now considered a promising therapeutic target in AD, which includes the only proven risk factor for AD - APOE, at two distinct levels - transcriptional regulation by LXR, and ABCA1 controlled lipidation which can influence Abeta aggregation and amyloid clearance. This review will summarize the results of research on ABCA1, particularly related to AD and neurodegeneration.

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  1. [1]Dean M Hamon Y Chimini G The human ATP-binding cassette (ABC) transporter superfamily J Lipid Res 42 7 2001 1007 1017 11441126
  2. [2]Luciani MF Denizot F Savary S Mattei MG Chimini G Cloning of two novel ABC transporters mapping on human chromosome 9 Genomics 21 1 1994 150 159 10.1006/geno.1994.1237 8088782 · DOI
  3. [3]Luciani MF Chimini G The ATP binding cassette transporter ABC1, is required for the engulfment of corpses generated by apoptotic cell death EMBO J 15 2 1996 226 235 8617198 PMC449937
  4. [4]Hamon Y Broccardo C Chambenoit O Luciani MF Toti F Chaslin S Freyssinet JM Devaux PF McNeish J Marguet D Chimini G ABC1 promotes engulfment of apoptotic cells and transbilayer redistribution of phosphatidylserine Nat Cell Biol 2 7 2000 399 406 10.1038/35017029 10878804 · DOI
  5. [5]Santamarina-Fojo S Peterson K Knapper C Qiu Y Freeman L Cheng JF Osorio J Remaley A Yang XP Haudenschild C Prades C Chimini G Blackmon E Francois T Duverger N Rubin EM Rosier M Denèfle P Fredrickson DS Brewer HB Jr Complete genomic sequence of the human ABCA1 gene: analysis of the human and mouse ATP-binding cassette A promoter Proc Natl Acad Sci U S A 97 14 2000 7987 7992 10884428 PMC16657
  6. [6]Oram JF Lawn RM ABCA1: the gatekeeper for eliminating excess tissue cholesterol J Lipid Res 42 8 2001 1173 1179 11483617
  7. [7]Bodzioch M Orsó E Klucken J Langmann T Böttcher A Diederich W Drobnik W Barlage S Büchler C Porsch-Ozcürümez M Kaminski WE Hahmann HW Oette K Rothe G Aslanidis C Lackner KJ Schmitz G The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease Nat Genet 22 4 1999 347 351 10.1038/11914 10431237 · DOI · Paper page
  8. [8]Brooks-Wilson A Marcil M Clee SM Zhang LH Roomp K van Dam M Yu L Brewer C Collins JA Molhuizen HO Loubser O Ouelette BF Fichter K Ashbourne-Excoffon KJ Sensen CW Scherer S Mott S Denis M Martindale D Frohlich J Morgan K Koop B Pimstone S Kastelein JJ Genest J Jr Hayden MR Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency Nat Genet 22 4 1999 336 345 10.1038/11905 10431236 · DOI · Paper page
  9. [9]Rust S Rosier M Funke H Real J Amoura Z Piette JC Deleuze JF Brewer HB Duverger N Denèfle P Assmann G Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1 Nat Genet 22 4 1999 352 355 10.1038/11921 10431238 · DOI · Paper page
  10. [10]Repa JJ Turley SD Lobaccaro JA Medina J Li L Lustig K Shan B Heyman RA Dietschy JM Mangelsdorf DJ Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers Science 289 5484 2000 1524 1529 10968783
  11. [11]Denis M Haidar B Marcil M Bouvier M Krimbou L Genest J Characterization of oligomeric human atp binding cassette transporter a1. Potential implications for determining the structure of nascent high density lipoprotein particles J Biol Chem 279 40 2004 41529 41536 10.1074/jbc.M406881200 15280376 · DOI
  12. [12]Trompier D Alibert M Davanture S Hamon Y Pierres M Chimini G Transition from dimers to higher oligomeric forms occurs during the atpase cycle of the ABCA1 transporter J Biol Chem 281 29 2006 20283 20290 10.1074/jbc. M601072200 16709568 · DOI
  13. [13]Vedhachalam C Ghering AB Davidson WS Lund-Katz S Rothblat GH Phillips MC ABCA1-induced cell surface binding sites for ApoA-I Arterioscler Thromb Vasc Biol 27 7 2007 1603 1609 10.1161/ATVBAHA.107.145789 17478755 · DOI
  14. [14]Vedhachalam C Duong PT Nickel M Nguyen D Dhanasekaran P Saito H Rothblat GH Lund-Katz S Phillips MC Mechanism of ATP-binding cassette transporter A1-mediated cellular lipid efflux to apolipoprotein A-I and formation of high density lipoprotein particles J Biol Chem 282 34 2007 25123 25130 10.1074/jbc.M704590200 17604270 · DOI
  15. [15]Yvan-Charvet L Wang N Tall AR Role of HDL, ABCA1, and ABCG1 transporters in cholesterol efflux and immune responses Arterioscler Thromb Vasc Biol 30 2 2010 139 143 10.1161/ATVBAHA.108.179283 19797709 PMC2812788 · DOI
  16. [16]Ho Hong S Rhyne J Zeller K Miller M Novel ABCA1 compound variant associated with HDL cholesterol deficiency cholesterol deficiency Biochim Biophys Acta 1587 1 2002 60 64 12009425
  17. [18]Saunders AM Strittmatter WJ Schmechel D George-Hyslop PH Pericak-Vance MA Joo SH Rosi BL Gusella JF Crapper-MacLachlan DR Alberts MJ Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer’s disease Neurology 43 8 1993 1467 1472 8350998
  18. [19]Corder EH Saunders AM Strittmatter WJ Schmechel DE Gaskell PC Small GW Roses AD Haines JL Pericak-Vance MA Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late onset families Science 261 5123 1993 921 923 8346443
  19. [20]Poirier J Davignon J Bouthillier D Kogan S Bertrand P Gauthier S Apolipoprotein E polymorphism and Alzheimer’s disease Lancet 342 8873 1993 697 699 8103819
  20. [21]Clee SM Zwinderman AH Engert JC Zwarts KY Molhuizen HO Roomp K Jukema JW van Wijland M van Dam M Hudson TJ Brooks-Wilson A Genest J Jr Kastelein JJ Hayden MR Common genetic variation in ABCA1 is associated with altered lipoprotein levels and a modified risk for coronary artery disease Circulation 103 9 2001 1198 1205 11238261
  21. [22]Li Y Tacey K Doil L van Luchene R Garcia V Rowland C Schrodi S Leong D Lau K Catanese J Sninsky J Nowotny P Holmans P Hardy J Powell J Lovestone S Thal L Owen M Williams J Goate A Grupe A Association of ABCA1 with late-onset Alzheimer’s disease is not observed in a case–control study Neurosci Lett 366 3 2004 268 271 10.1016/j.neulet.2004.05.047 15288432 · DOI
  22. [23]Wollmer MA Streffer JR Lütjohann D Tsolaki M Iakovidou V Hegi T Pasch T Jung HH Bergmann Kv Nitsch RM Hock C Papassotiropoulos A ABCA1 modulates CSF cholesterol levels and influences the age at onset of Alzheimer’s disease Neurobiol Aging 24 3 2003 421 426 12600718
  23. [24]Shibata N Kawarai T Lee JH Lee HS Shibata E Sato C Liang Y Duara R Mayeux RP St George-Hyslop PH Rogaeva E Association studies of cholesterol metabolism genes (CH25H, ABCA1 and CH24H) in Alzheimer’s disease Neurosci Lett 391 3 2006 142 146 10.1016/j.neulet.2005.08.048 16157450 · DOI
  24. [25]Wahrle SE Shah AR Fagan AM Smemo S Kauwe JSK Grupe A Hinrichs A Mayo K Jiang H Thal LJ Goate AM Holtzman DM Apolipoprotein E levels in cerebrospinal fluid and the effects of ABCA1 polymorphisms Mol Neurodegener 2 2007 7 10.1186/1750-1326-2-7 17430597 PMC1857699 · DOI · Paper page
  25. [26]Chu LW Li Y Li Z Tang AYB Cheung BMY Leung RYH Yik PY Jin DY Song YQ A novel intronic polymorphism of ABCA1 gene reveals risk for sporadic Alzheimer’s disease in Chinese Am J Med Genet B Neuropsychiatr Genet 144B 8 2007 1007 1013 10.1002/ajmg.b.30525 17510949 · DOI
  26. [27]Bertram L Hiltunen M Parkinson M Ingelsson M Lange C Ramasamy K Mullin K Menon R Sampson AJ Hsiao MY Elliott KJ Velicelebi G Moscarillo T Hyman BT Wagner SL Becker KD Blacker D Tanzi RE Family-based association between Alzheimer’s disease and variants in UBQLN1 N Engl J Med 352 9 2005 884 894 10.1056/NEJMoa042765 15745979 · DOI
  27. [28]Katzov H Chalmers K Palmgren J Andreasen N Johansson B Cairns NJ Gatz M Wilcock GK Love S Pedersen NL Brookes AJ Blennow K Kehoe PG Prince JA Genetic variants of ABCA1 modify Alzheimer disease risk and quantitative traits related to beta-amyloid metabolism Hum Mutat 23 4 2004 358 367 10.1002/humu.20012 15024730 · DOI
  28. [29]Reynolds CA Hong MG Eriksson UK Blennow K Bennet AM Johansson B Malmberg B Berg S Wiklund F Gatz M Pedersen NL Prince JA A survey of ABCA1 sequence variation confirms association with dementia Hum Mutat 30 9 2009 1348 1354 10.1002/humu.21076 19606474 PMC2758418 · DOI
  29. [30]Wang F Jia J Polymorphisms of cholesterol metabolism genes CYP46 and ABCA1 and the risk of sporadic Alzheimer’s disease in Chinese Brain Res 1147 1 2007 34 38 cited by (since 1996) 9. (URL http://www.scopus.com/inward/record.url?eid=2-s2.0-34147158749&partnerID=40 17335784
  30. [31]Wavrant-De Vrièze F Compton D Womick M Arepalli S Adighibe O Li L Pérez-Tur J Hardy J ABCA1 polymorphisms and Alzheimer’s disease Neurosci Lett 416 2 2007 180 183 10.1016/j.neulet.2007.02.010 17324514 PMC1945126 · DOI
  31. [32]Rodríguez-Rodríguez E Mateo I Llorca J Sánchez-Quintana C Infante J García-Gorostiaga I Sánchez-Juan P Berciano J Combarros O Association of genetic variants of ABCA1 with Alzheimer’s disease risk Am J Med Genet B Neuropsychiatr Genet 144B 7 2007 964 968 10.1002/ajmg.b.30552 17510946 · DOI
  32. [34]Lambert J-C Heath S Even G Campion D Sleegers K Hiltunen M Combarros O Zelenika D Bullido MJ Tavernier B Letenneur L Bettens K Berr C Pasquier F Fiévet N Barberger-Gateau P Engelborghs S De Deyn P Mateo I Franck A Helisalmi S Porcellini E Hanon O de Pancorbo MM Lendon C Dufouil C Jaillard C Leveillard T Alvarez V Bosco P Mancuso M Panza F Nacmias B Bossù P Piccardi P Annoni G Seripa D Galimberti D Hannequin D Licastro F Soininen H Ritchie K Blanché H Dartigues J-F Tzourio C Gut I Van Broeckhoven C Alpérovitch A Lathrop M Amouyel P European Alzheimer’s Disease Initiative Investigators Genome-wide association study identifies variants at clu and cr1 associated with Alzheimer’s disease Nat Genet 41 10 2009 1094 1099 10.1038/ng.439 19734903 · DOI · Paper page
  33. [35]Walter M Kerber S Fechtrup C Seedorf U Breithardt G Assmann G Characterization of atherosclerosis in a patient with familial high-density lipoprotein deficiency Atherosclerosis 110 2 1994 203 208 7848370
  34. [36]Cohen JC Kiss RS Pertsemlidis A Marcel YL McPherson R Hobbs HH Multiple rare alleles contribute to low plasma levels of HDL cholesterol Science 305 5685 2004 869 872 10.1126/science.1099870 15297675 · DOI · Paper page
  35. [37]Iatan I Alrasadi K Ruel I Alwaili K Genest J Effect of ABCA1 mutations on risk for myocardial infarction Curr Atheroscler Rep 10 5 2008 413 426 18706283
  36. [38]Langmann T Klucken J Reil M Liebisch G Luciani MF Chimini G Kaminski WE Schmitz G Molecular cloning of the human ATP-binding cassette transporter 1 (hABC1): evidence for sterol-dependent regulation in macrophages Biochem Biophys Res Commun 257 1 1999 29 33 10.1006/bbrc.1999.0406 10092505 · DOI
  37. [39]Lawn RM Wade DP Couse TL Wilcox JN Localization of human ATP-binding cassette transporter 1 (ABC1) in normal and atherosclerotic tissues Arterioscler Thromb Vasc Biol 21 3 2001 378 385 11231917
  38. [40]Whitney KD Watson MA Collins JL Benson WG Stone TM Numerick MJ Tippin TK Wilson JG Winegar DA Kliewer SA Regulation of cholesterol homeostasis by the liver X receptors in the central nervous system Mol Endocrinol 16 6 2002 1378 1385 12040022
  39. [41]Fukumoto H Deng A Irizarry MC Fitzgerald ML Rebeck GW Induction of the cholesterol transporter ABCA1 in central nervous system cells by liver X receptor agonists increases secreted Aβ levels J Biol Chem 277 50 2002 48508 48513 10.1074/jbc.M209085200 12384498 · DOI
  40. [42]Koldamova RP Lefterov IM Ikonomovic MD Skoko J Lefterov PI Isanski BA DeKosky ST Lazo JS 22r-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion J Biol Chem 278 15 2003 13244 13256 10.1074/jbc.M300044200 12547833 · DOI · Paper page
  41. [43]Wahrle SE Jiang H Parsadanian M Legleiter J Han X Fryer JD Kowalewski T Holtzman DM ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE J Biol Chem 279 39 2004 40987 40993 10.1074/jbc.M407963200 15269217 · DOI · Paper page
  42. [44]Hirsch-Reinshagen V Zhou S Burgess BL Bernier L McIsaac SA Chan JY Tansley GH Cohn JS Hayden MR Wellington CL Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain J Biol Chem 279 39 2004 41197 41207 10.1074/jbc.M407962200 15269218 · DOI · Paper page
  43. [45]Kim WS Rahmanto AS Kamili A Rye KA Guillemin GJ Gelissen IC Jessup W Hill AF Garner B Role of ABCG1 and ABCA1 in regulation of neuronal cholesterol efflux to apolipoprotein E discs and suppression of amyloid-beta peptide generation J Biol Chem 282 5 2007 2851 2861 10.1074/jbc.M607831200 17121837 · DOI · Paper page
  44. [47]Brown J III Theisler C Silberman S Magnuson D Gottardi-Littell N Lee JM Yager D Crowley J Sambamurti K Rahman MM Reiss AB Eckman CB Wolozin B Differential expression of cholesterol hydroxylases in Alzheimer’s disease J Biol Chem 279 33 2004 34674 34681 10.1074/jbc.M402324200 15148325 · DOI
  45. [48]Sun Y Yao J Kim TW Tall AR Expression of liver X receptor target genes decreases cellular amyloid beta peptide secretion J Biol Chem 278 30 2003 27688 27694 10.1074/jbc.M300760200 12754201 · DOI · Paper page
  46. [49]Burns MP Vardanian L Pajoohesh-Ganji A Wang L Cooper M Harris DC Duff K Rebeck GW The effects of ABCA1 on cholesterol efflux and Aβ levels in vitro and in vivo J Neurochem 98 3 2006 792 800 10.1111/j.1471-4159.2006.03925.x 16771834 · DOI · Paper page
  47. [51]Riddell DR Zhou H Comery TA Kouranova E Lo CF Warwick HK Ring RH Kirksey Y Aschmies S Xu J Kubek K Hirst WD Gonzales C Chen Y Murphy E Leonard S Vasylyev D Oganesian A Martone RL Pangalos MN Reinhart PH Jacobsen JS The LXR agonist TO901317 selectively lowers hippocampal Aβ42 and improves memory in the Tg2576 mouse model of Alzheimer’s disease Mol Cell Neurosci 34 4 2007 621 628 10.1016/j.mcn.2007.01.011 17336088 · DOI · Paper page
  48. [53]Karasinska JM Rinninger F Lütjohann D Ruddle P Franciosi S Kruit JK Singaraja RR Hirsch-Reinshagen V Fan J Brunham LR Bissada N Ramakrishnan R Wellington CL Parks JS Hayden MR Specific loss of brain ABCA1 increases brain cholesterol uptake and influences neuronal structure and function J Neurosci 29 11 2009 3579 3589 10.1523/JNEUROSCI.4741-08.2009 19295162 PMC2678874 · DOI
  49. [54]Koldamova RP Lefterov IM Lefterova MI Lazo JS Apolipoprotein A-I directly interacts with amyloid precursor protein and inhibits A-beta aggregation and toxicity Biochemistry 40 12 2001 3553 3560 11297421
  50. [55]Balazs Z Panzenboeck U Hammer A Sovic A Quehenberger O Malle E Sattler W Uptake and transport of high-density lipoprotein (HDL) and HDL-associated alpha-tocopherol by an in vitro blood–brain barrier model J Neurochem 89 4 2004 939 950 10.1111/j.1471-4159.2004.02373.x 15140193 · DOI
  51. [56]Panzenboeck U Balazs Z Sovic A Hrzenjak A Levak-Frank S Wintersperger A Malle E Sattler W ABCA1 and scavenger receptor class B, type I, are modulators of reverse sterol transport at an in vitro blood–brain barrier constituted of porcine brain capillary endothelial cells J Biol Chem 277 45 2002 42781 42789 10.1074/jbc.M207601200 12202492 · DOI
  52. [57]Hong SH Riley W Rhyne J Friel G Miller M Lack of association between increased carotid intima-media thickening and decreased HDL-cholesterol in a family with a novel ABCA1 variant, g2265t Clin Chem 48 11 2002 2066 2070 12407001
  53. [59]Lefterov I Fitz NF Cronican A Lefterov P Staufenbiel M Koldamova R Memory deficits in APP23/Abca1+/− mice correlate with the level of Aβ oligomers ASN Neuro 1 2 10.1042/AN20090015 PMC2695585 19570031 · DOI
  54. [60]Miao J Vitek MP Xu F Previti ML Davis J Van Nostrand WE Reducing cerebral microvascular amyloid-beta protein deposition diminishes regional neuroinflam-mation in vasculotropic mutant amyloid precursor protein transgenic mice J Neurosci 25 27 2005 6271 6277 10.1523/JNEUROSCI.1306-05.2005 16000616 PMC6725284 · DOI
  55. [61]Pfrieger FW Barres BA Synaptic efficacy enhanced by glial cells in vitro Science 277 5332 1997 1684 1687 9287225
  56. [62]Mauch DH Nägler K Schumacher S Göritz C Müller EC Otto A Pfrieger FW CNS synaptogenesis promoted by glia-derived cholesterol Science 294 5545 2001 1354 1357 10.1126/science.294.5545.1354 11701931 · DOI · Paper page
  57. [63]Zelcer N Khanlou N Clare R Jiang Q Reed-Geaghan EG Landreth GE Vinters HV Tontonoz P Attenuation of neuroinflammation and Alzheimer’s disease pathology by liver x receptors Proc Natl Acad Sci U S A 104 25 2007 10601 10606 10.1073/pnas.0701096104 17563384 PMC1890560 · DOI · Paper page
  58. [64]Cronican AA Fitz NF Pham T Fogg A Kifer B Koldamova R Lefterov I Proton pump inhibitor Lansoprazole is a nuclear liver X receptor agonist Biochem Pharmacol 79 9 2010 1310 1316 10.1016/j.bcp.2009.12.018 20060385 PMC2834822 · DOI
  59. [65]Suzuki S Nishimaki-Mogami T Tamehiro N Inoue K Arakawa R Abe-Dohmae S Tanaka AR Ueda K Yokoyama S Verapamil increases the apolipo-protein-mediated release of cellular cholesterol by induction of ABCA1 expression via Liver X receptor-independent mechanism Arterioscler Thromb Vasc Biol 24 3 2004 519 525 10.1161/01.ATV.0000117178.94087.ba 14726413 · DOI
  60. [66]Wang N Tall AR Regulation and mechanisms of ATP-binding cassette transporter A1-mediated cellular cholesterol efflux Arterioscler Thromb Vasc Biol 23 7 2003 1178 1184 10.1161/01.ATV.0000075912.83860.26 12738681 · DOI
  61. [67]Wang N Chen W Linsel-Nitschke P Martinez LO Agerholm-Larsen B Silver DL Tall AR A PEST sequence in ABCA1 regulates degradation by calpain protease and stabilization of ABCA1 by apoA-I J Clin Invest 111 1 2003 99 107 10.1172/JCI16808 12511593 PMC151839 · DOI
  62. [68]Chen W Wang N Tall AR A PEST deletion mutant of ABCA1 shows impaired internalization and defective cholesterol efflux from late endosomes J Biol Chem 280 32 2005 29277 29281 10.1074/jbc.M505566200 15951431 · DOI
  63. [69]Martinez LO Agerholm-Larsen B Wang N Chen W Tall AR Phosphorylation of a pest sequence in ABCA1 promotes calpain degradation and is reversed by ApoA-I J Biol Chem 278 39 2003 37368 37374 10.1074/jbc.M307161200 12869555 · DOI
  64. [70]Feng B Tabas I ABCA1-mediated cholesterol efflux is defective in free cholesterol-loaded macrophages. Mechanism involves enhanced ABCA1 degradation in a process requiring full NPC1 activity J Biol Chem 277 45 2002 43271 43280 10.1074/jbc.M207532200 12215451 · DOI
  65. [72]Panzenboeck U Kratzer I Sovic A Wintersperger A Bernhart E Hammer A Malle E Sattler W Regulatory effects of synthetic liver X receptor- and peroxisome-proliferator activated receptor agonists on sterol transport pathways in polarized cerebrovascular endothelial cells Int J Biochem Cell Biol 38 8 2006 1314 1329 10.1016/j.biocel.2006.01.013 16530456 · DOI
  66. [73]Gosselet F Candela P Sevin E Berezowski V Cecchelli R Fenart L Transcriptional profiles of receptors and transporters involved in brain cholesterol homeostasis at the blood–brain barrier: use of an in vitro model Brain Res 1249 2009 34 42 10.1016/j.brainres.2008.10.036 18996096 · DOI

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Authors
Koldamova, R., Fitz, N. F., & Lefterov, I.
Affiliations
University of Pittsburgh (US)
Corresponding author
  • Koldamova, Radosveta
  • Lefterov, Iliya
ORCID
Venue
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Publisher
Elsevier BV
Published
2010-08
Volume
1801
Issue
8
Pages
824-830
ISSN
1388-1981 (ISSN-L)
DOI
10.1016/j.bbalip.2010.02.010
PMC
PMC3712769
OpenAlex
W2048100774
Cited by
102
References
6
Citations by year
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FWCI
6.72
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute on Aging (AG027973, AG031956, R01AG027973, R21AG031956)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Keywords
ABCA1, Alzheimer's disease, neurodegeneration, amyloid-beta clearance, amyloid-beta deposition, apolipoprotein E, liver X receptor, cholesterol efflux, HDL biogenesis, Tangier disease, arteriosclerosis, lipid modification, therapeutic target
MeSH terms
Alzheimer Disease, Animals, Central Nervous System, Cholesterol, Humans, Nerve Degeneration, Genetic Variation, ATP-Binding Cassette Transporters, ATP Binding Cassette Transporter 1

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