The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Lipids in Alzheimer’s disease: A century-old story
Abstract
Three neuropathological features attracted the attention of Alzheimer in his examination of the brain of Auguste Deter: abnormal fibrillary structures, cortical depositions now termed "plaques," and glial proliferation, whereby he noted remarkable lipid granule accumulation in the glia. These features were also recorded by Perusini and Kraepelin, but by 1930 the lipoid deposits were no longer regarded by neuropathologists with great interest.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Since LD accumulation is a component of AD [67,68], and there are reduced levels of LPL in the dentate gyrus of patients with AD [27], it is plausible that reduced LPL in AD could contribute to LDAM physiology, increased CE load, microglial dysfunction, and disease progression.”
From Lipoprotein Lipase Regulates Microglial Lipid Droplet Accumulation (2021) · cites this paper as [68]
Citations
Cites
Uber eine eigenartige Erkrankung der Hirnrinde
Alzheimer, A. (1907) · Medical Entomology and Zoology · Cited by 1,503
über eigenartige Krankheitsfälle des späteren Alters
Alzheimer, A. (1911) · Zeitschrift für die gesamte Neurologie und Psychiatrie · doi:10.1007/bf02866241 · Cited by 712
Lewandowsky, M. (1912) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-191206000-00015 · Cited by 691
Handbuch der Geisteskrankheiten
Bumke, O., Ewald, G., Haug, K., Luxenburger, H., & Scheid, F. M. (1939) · Springer eBooks · doi:10.1007/978-3-642-47333-3 · Cited by 238
Fischer, P.-D. O. (2009) · Monatsschrift für Psychiatrie und Neurologie · doi:10.1159/000211873 · Cited by 186
Pigments in Aging: An Overview
Porta, E. A. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02083.x · Cited by 173
(1972) · Springer eBooks · doi:10.1007/978-3-642-65278-3 · Cited by 86
A STUDY OF THE MILIARY PLAQUES FOUND IN BRAINS OF THE AGED
Fuller, S. C. (1911) · American Journal of Psychiatry · doi:10.1176/ajp.68.2.147 · Cited by 32
The contribution of Gaetano Perusini to the definition of Alzheimer’s disease
Lucci, B. (1998) · The Italian Journal of Neurological Sciences · doi:10.1007/bf03028813 · Cited by 24
The Morbid Changes in the Cerebro-Spinal Nervous System of the Aged Insane
Campbell, A. W. (1894) · Journal of Mental Science · doi:10.1192/bjp.40.171.638 · Cited by 15
Cited by
Sorted by citations
Marschallinger, J., Iram, T., Zardeneta, M., Lee, S. E., Lehallier, B., Haney, M. S., Pluvinage, J. V., Mathur, V., Hahn, O., Morgens, D. W., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-019-0566-1 · Cited by 1,384
Linking lipids to Alzheimer's disease: cholesterol and beyond
Di Paolo, G., & Kim, T.-W. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3012 · Cited by 972
TREM2 regulates microglial cholesterol metabolism upon chronic phagocytic challenge
Nugent, A. A., Lin, K., van Lengerich, B., Lianoglou, S., Przybyla, L., Davis, S. S., Llapashtica, C., Wang, J., Kim, D. J., Xia, D., et al. (2020) · Neuron · doi:10.1016/j.neuron.2019.12.007 · Cited by 745
Comparative Lipidomic Analysis of Mouse and Human Brain with Alzheimer Disease
Chan, R. B., Oliveira, T. G., Cortes, E. P., Honig, L. S., Duff, K. E., Small, S. A., Wenk, M. R., Shui, G., & Di Paolo, G. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.274142 · Cited by 630
APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes
Blanchard, J. W., Akay, L. A., Davila-Velderrain, J., von Maydell, D., Mathys, H., Davidson, S. M., Effenberger, A., Chen, C.-Y., Maner-Smith, K., Hajjar, I., et al. (2022) · Nature · doi:10.1038/s41586-022-05439-w · Cited by 496
Metadata
- Authors
- Foley, P.
- Affiliations
- Neuroscience Research Australia (AU)
- Corresponding author
- Foley, Paul
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
- Publisher
- Elsevier BV
- Published
- 2010-08
- Volume
- 1801
- Issue
- 8
- Pages
- 750-753
- ISSN
- 1388-1981 (ISSN-L)
- OpenAlex
- W2040912634
- Cited by
- 186
- References
- 12
- Citations by year
- 2026: 8 · 2025: 24 · 2024: 20 · 2023: 10 · 2022: 15 · 2021: 12 · 2020: 28 · 2019: 9 · 2018: 10 · 2017: 6 · 2016: 10 · 2015: 9 · 2014: 10 · 2013: 8 · 2012: 3
- FWCI
- 3.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, lipids, lipid granules, glial cell proliferation, amyloid plaques, neurofibrillary tangles, history of Alzheimer's disease, neuropathology
- MeSH terms
- Alzheimer Disease, Brain, Humans, Lipids, History, 20th Century, History, 21st Century, Lipid Metabolism
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
