The DOI matches its Crossref record; 125 of the 125 references it cites were found in a registry or an index.
Mammalian Carotenoid-oxygenases: Key players for carotenoid function and homeostasis
Open accessAbstract
Humans depend on a dietary intake of lipids to maintain optimal health. Among various classes of dietary lipids, the physiological importance of carotenoids is still controversially discussed. On one hand, it is well established that carotenoids, such as β,β-carotene, are a major source for vitamin A that plays critical roles for vision and many aspects of cell physiology. On the other hand, large clinical trials have failed to show clear health benefits of carotenoids supplementation and even suggest adverse health effects in individuals at risk of disease. In recent years, key molecular players for carotenoid metabolism have been identified, including an evolutionarily well conserved family of carotenoid-oxygenases. Studies in knockout mouse models for these enzymes revealed that carotenoid metabolism is a highly regulated process and that this regulation already takes place at the level of intestinal absorption. These studies also provided evidence that β,β-carotene conversion can influence retinoid-dependent processes in the mouse embryo and in adult tissues. Moreover, these analyses provide an explanation for adverse health effects of carotenoids by showing that a pathological accumulation of these compounds can induce oxidative stress in mitochondria and cell signaling pathways related to disease. Advancing knowledge about carotenoid metabolism will contribute to a better understanding of the biochemical and physiological roles of these important micronutrients in health and disease. This article is part of a Special Issue entitled Retinoid and Lipid Metabolism.
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“CCOs are characterized by their ability to cleave the carotenoid polyene backbone with high stereoselectivity and regioselectivity, thus cleaving only selected polyenes at specific sites leaving specific products with very high fidelity [13,14,15].”
From Vitamin A Transporters in Visual Function: A Mini Review on Membrane Receptors for Dietary Vitamin A Uptake, Storage, and Transport to the Eye (2021) · cites this paper as [13]
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“In the β-carotene metabolic pathway, BCO1 catalyzes the cleavage of β-carotene taken in through SCARB1 into two molecules of retinal through symmetrical cleavage of β-carotene.”
From Vitamin A Transporters in Visual Function: A Mini Review on Membrane Receptors for Dietary Vitamin A Uptake, Storage, and Transport to the Eye (2021) · cites this paper as [13]
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Metadata
- Authors
- Lobo, G. P., Amengual, J., Palczewski, G., Babino, D., & von Lintig, J.
- Affiliations
- Case Western Reserve University (US)
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 1821
- Issue
- 1
- Pages
- 78-87
- ISSN
- 1388-1981 (ISSN-L)
- PMC
- PMC3162997
- OpenAlex
- W2046674715
- Cited by
- 125
- References
- 125
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 6 · 2023: 8 · 2022: 6 · 2021: 7 · 2020: 6 · 2019: 5 · 2018: 12 · 2017: 8 · 2016: 10 · 2015: 13 · 2014: 6 · 2013: 14 · 2012: 13
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Health (EY019641)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
- Keywords
- carotenoid metabolism, vitamin A, retinoids, intestinal absorption, knockout mouse models, oxidative stress, mitochondrial stress, carotenoid accumulation, dietary carotenoids, carotenoid supplementation
- MeSH terms
- Animals, Carotenoids, Homeostasis, Humans, Intestinal Absorption, Liver, Mitochondria, Liver, Oxygenases, Vitamin A, Signal Transduction, Mice, Knockout, Oxidative Stress, beta-Carotene 15,15'-Monooxygenase, Mice
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