Cited by 125Antioxidant Activity and Oxidative StressRetinoids in leukemia and cellular processesPlant biochemistry and biosynthesis

The DOI matches its Crossref record; 125 of the 125 references it cites were found in a registry or an index.

Mammalian Carotenoid-oxygenases: Key players for carotenoid function and homeostasis

Open access

Lobo, Glenn P., Amengual, Jaume, Palczewski, Grzegorz, Babino, Darwin, von Lintig, Johannes·2012·Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

DOI 10.1016/j.bbalip.2011.04.010PMC PMC3162997

Open this paper in CoChat — free account

Abstract

Humans depend on a dietary intake of lipids to maintain optimal health. Among various classes of dietary lipids, the physiological importance of carotenoids is still controversially discussed. On one hand, it is well established that carotenoids, such as β,β-carotene, are a major source for vitamin A that plays critical roles for vision and many aspects of cell physiology. On the other hand, large clinical trials have failed to show clear health benefits of carotenoids supplementation and even suggest adverse health effects in individuals at risk of disease. In recent years, key molecular players for carotenoid metabolism have been identified, including an evolutionarily well conserved family of carotenoid-oxygenases. Studies in knockout mouse models for these enzymes revealed that carotenoid metabolism is a highly regulated process and that this regulation already takes place at the level of intestinal absorption. These studies also provided evidence that β,β-carotene conversion can influence retinoid-dependent processes in the mouse embryo and in adult tissues. Moreover, these analyses provide an explanation for adverse health effects of carotenoids by showing that a pathological accumulation of these compounds can induce oxidative stress in mitochondria and cell signaling pathways related to disease. Advancing knowledge about carotenoid metabolism will contribute to a better understanding of the biochemical and physiological roles of these important micronutrients in health and disease. This article is part of a Special Issue entitled Retinoid and Lipid Metabolism.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.bbalip.2011.04.010

Cites

125 of 125 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Induction of the Vitamin D Receptor Attenuates Autophagy Dysfunction-Mediated Cell Death Following Traumatic Brain Injury
Cui, C., Cui, J., Jin, F., Cui, Y., Li, R., Jiang, X., Tian, Y., Wang, R. C., Jiang, P., & Gao, J. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479571 · Cited by 5,214
A decade of molecular biology of retinoic acid receptors
Chambon, P. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.9.8801176 · Cited by 2,889 · cited 1×
“This hormone-like compound is the ligand of retinoic acid receptors (RARs) that require retinoid X receptors (RXRs) as partners [41].”
Background
Mortality in Randomized Trials of Antioxidant Supplements for Primary and Secondary Prevention: Systematic Review and Meta-analysis
Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. (2007) · JAMA · doi:10.1001/jama.297.8.842 · Cited by 2,275
A human retinoic acid receptor which belongs to the family of nuclear receptors
Petkovich, M., Brand, N. J., Krust, A., & Chambon, P. (1987) · Nature · doi:10.1038/330444a0 · Cited by 2,214
Nuclear Hormone Receptors and Gene Expression
Aranda, A., & Pascual, A. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1269 · Cited by 1,608
International Union of Pharmacology. LXI. Peroxisome Proliferator-Activated Receptors
Michalik, L., Auwerx, J. H., Berger, J. P., Chatterjee, K., Glass, C. K., Gonzalez, F. J., Grimaldi, P. A., Kadowaki, T., Lazar, M. A., O’Rahilly, S., et al. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.4.5 · Cited by 1,022
Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle
Redmond., T. M., Yu, S., Lee, E., Bok, D., Hamasaki, D., Chen, N., Goletz, P., Ma, J.-X., Crouch, R. K., & Pfeifer, K. (1998) · Nature Genetics · doi:10.1038/3813 · Cited by 929
Specific Oxidative Cleavage of Carotenoids by VP14 of Maize
Schwartz, S. H., Tan, B. C., Gage, D. A., Zeevaart, J. A. D., & McCarty, D. R. (1997) · Science · doi:10.1126/science.276.5320.1872 · Cited by 909
Evidence for protection against age-related macular degeneration by carotenoids and antioxidant vitamins
Snodderly, D. M. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/62.6.1448s · Cited by 799
G Protein–Coupled Receptor Rhodopsin
Palczewski, K. (2006) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.75.103004.142743 · Cited by 764
Antioxidants in Photosynthesis and Human Nutrition
Demmig‐Adams, B., & Adams, W. W. (2002) · Science · doi:10.1126/science.1078002 · Cited by 685
Carotenoid Modulation of Immune Function and Sexual Attractiveness in Zebra Finches
Blount, J. D., Metcalfe, N. B., Birkhead, T. R., & Surai, P. F. (2003) · Science · doi:10.1126/science.1082142 · Cited by 642
BIOAVAILABILITY AND BIOCONVERSION OF CAROTENOIDS
Castenmiller, J. J. M., & West, C. E. (1998) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.18.1.19 · Cited by 608
Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists
Mukherjee, R., Davies, P. J., Crombie, D. L., Bischoff, E. D., Cesario, R. M., Jow, L., Hamann, L. G., Boehm, M. F., Mondon, C. E., Nadzan, A. M., et al. (1997) · Nature · doi:10.1038/386407a0 · Cited by 601
RPE65 is the isomerohydrolase in the retinoid visual cycle
Moiseyev, G., Chen, Y., Takahashi, Y., Wu, B. X., & Ma, J.-X. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503460102 · Cited by 536
Impaired retinal function and vitamin A availability in mice lacking retinol‐binding protein
Quadro, L., Blaner, W. S., Salchow, D. J., Vogel, S., Piantedosi, R., Gouras, P., Freeman, S., Cosma, M. P., Colantuoni, V., & Gottesman, M. E. (1999) · The EMBO Journal · doi:10.1093/emboj/18.17.4633 · Cited by 506
Identification and Characterization of a Mammalian Enzyme Catalyzing the Asymmetric Oxidative Cleavage of Provitamin A
Kiefer, C., Hessel, S., Lampert, J. M., Vogt, K., Lederer, M. O., Breithaupt, D. E., & Lintig, J. V. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011510200 · Cited by 453
Filling the Gap in Vitamin A Research
von Lintig, J., & Vogt, K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.16.11915 · Cited by 449
Identification of the Yellow Skin Gene Reveals a Hybrid Origin of the Domestic Chicken
Eriksson, J., Larson, G., Gunnarsson, U., Bed'hom, B., Tixier-Boichard, M., Strömstedt, L., Wright, D., Jungerius, A., Vereijken, A., Randi, E., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000010 · Cited by 426
Rpe65 is the retinoid isomerase in bovine retinal pigment epithelium
Jin, M., Li, S., Moghrabi, W. N., Sun, H., & Travis, G. H. (2005) · Cell · doi:10.1016/j.cell.2005.06.042 · Cited by 424
Mutation of key residues of RPE65 abolishes its enzymatic role as isomerohydrolase in the visual cycle
Redmond, T. M., Poliakov, E., Yu, S., Tsai, J.-Y., Lu, Z., & Gentleman, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504167102 · Cited by 409
Macular pigment and risk for age-related macular degeneration in subjects from a Northern European population.
Beatty, S., Murray, I. J., Henson, D. B., Carden, D. E., Koh, H.-H., & Boulton, M. (2001) · PubMed · Cited by 408
Immune Activation Rapidly Mirrored in a Secondary Sexual Trait
Faivre, B., Grégoire, A., Préault, M., Cézilly, F., & Sorci, G. (2003) · Science · doi:10.1126/science.1081802 · Cited by 396
Retinaldehyde represses adipogenesis and diet-induced obesity
Ziouzenkova, O., Orasanu, G., Sharlach, M., Akiyama, T. E., Berger, J. P., Viereck, J. C., Hamilton, J. A., Tang, G., Dolnikowski, G. G., Vogel, S., et al. (2007) · Nature Medicine · doi:10.1038/nm1587 · Cited by 380
All- trans -Retinoic Acid Represses Obesity and Insulin Resistance by Activating both Peroxisome Proliferation-Activated Receptor β/δ and Retinoic Acid Receptor
Berry, D. C., & Noy, N. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01742-08 · Cited by 345
The enzymatic cleavage of beta-carotene into vitamin A by soluble enzymes of rat liver and intestine.
Olson, J. A., & Hayaishi, O. (1965) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.54.5.1364 · Cited by 342
The transcriptional basis of adipocyte development.
Rosen, E. (2005) · Prostaglandins, Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2005.04.004 · Cited by 320
Regulation of Intestinal Cholesterol Absorption
Wang, D. Q. ‐. (2006) · Annual Review of Physiology · doi:10.1146/annurev.physiol.69.031905.160725 · Cited by 311
A mitochondrial enzyme degrades carotenoids and protects against oxidative stress
Amengual, J., Lobo, G. P., Golczak, M., Li, H. N. M., Klimova, T. A., Hoppel, C. L., Wyss, A., Palczewski, K., & Lintig, J. V. (2010) · The FASEB Journal · doi:10.1096/fj.10-173906 · Cited by 304
Self-citation
Retinoic Acid Blocks Adipogenesis by Inhibiting C/EBPβ-Mediated Transcription
Schwarz, E. J., Reginato, M. J., Shao, D., Krakow, S. L., & Lazar, M. A. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.3.1552 · Cited by 302
Retinoid absorption and storage is impaired in mice lacking lecithin:retinol acyltransferase (LRAT)
O'Byrne, S. M., Wongsiriroj, N., Libien, J., Vogel, S., Goldberg, I. J., Baehr, W., Palczewski, K., & Blaner, W. S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507924200 · Cited by 296
Class B Scavenger Receptor-Mediated Intestinal Absorption of Dietary β-Carotene and Cholesterol
van Bennekum, A., Werder, M., Thuahnai, S. T., Han, C.-H., Duong, P., Williams, D. L., Wettstein, P., Schulthess, G., Phillips, M. C., & Hauser, H. (2005) · Biochemistry · doi:10.1021/bi0484320 · Cited by 290
Identification, Expression, and Substrate Specificity of a Mammalian β-Carotene 15,15′-Dioxygenase
Redmond, T. M., Gentleman, S., Duncan, T. E., Yu, S., Wiggert, B. O., Gantt, E., & Cunningham, F. X. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009030200 · Cited by 279
Biosynthesis of Vitamin A with Rat Intestinal Enzymes
Goodman, D. S., & Huang, H. S. (1965) · Science · doi:10.1126/science.149.3686.879 · Cited by 263
The Structure of a Retinal-Forming Carotenoid Oxygenase
Kloer, D. P., Ruch, S., Al‐Babili, S., Beyer, P., & Schulz, G. E. (2005) · Science · doi:10.1126/science.1108965 · Cited by 261
CMO1 Deficiency Abolishes Vitamin A Production from β-Carotene and Alters Lipid Metabolism in Mice
Hessel, S., Eichinger, A., Isken, A., Amengual, J., Hunzelmann, S., Hoeller, U., Elste, V., Hunziker, W., Goralczyk, R., Oberhauser, V., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706763200 · Cited by 259
Self-citation
A class B scavenger receptor mediates the cellular uptake of carotenoids in Drosophila
Kiefer, C., Sumser, E., Wernet, M. F., & von Lintig, J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162182899 · Cited by 255
Carotenoid uptake and secretion by CaCo-2 cells: β-carotene isomer selectivity and carotenoid interactions
During, A., Hussain, M. M., Morel, D. W., & Harrison, E. H. (2002) · Journal of Lipid Research · doi:10.1194/jlr.m200068-jlr200 · Cited by 255
Scavenger Receptor Class B Type I (SR-BI) Is Involved in Vitamin E Transport across the Enterocyte
Reboul, E., Klein, A., Biétrix, F., Gleize, B., Malezet‐Desmoulins, C., Schneider, M., Margotat, A., Lagrost, L., Collet, X., & Borel, P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509042200 · Cited by 252
Common Variation in the β-Carotene 15,15′-Monooxygenase 1 Gene Affects Circulating Levels of Carotenoids: A Genome-wide Association Study
Ferrucci, L., Perry, J. R. B., Matteini, A. M., Perola, M., Tanaka, T., Silander, K., Rice, N. E., Melzer, D. R., Murray, A., Cluett, C., et al. (2009) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.12.019 · Cited by 251
Identification of a Receptor Mediating Absorption of Dietary Cholesterol in the Intestine
Hauser, H., Dyer, J. H., Nandy, A., Vega, M. A., Werder, M., Bieliauskaite, E., Weber, F. E., Compassi, S., Gemperli, A. C., Boffelli, D., et al. (1998) · Biochemistry · doi:10.1021/bi982404y · Cited by 249
ISX is a retinoic acid-sensitive gatekeeper that controls intestinal β,β-carotene absorption and vitamin A production
Lobo, G. P., Hessel, S., Eichinger, A., Noy, N., Moise, A. R., Wyss, A., Palczewski, K., & Von Lintig, J. (2010) · The FASEB Journal · doi:10.1096/fj.09-150995 · Cited by 248
Self-citation
Remodeling of White Adipose Tissue after Retinoic Acid Administration in Mice
Mercader, J., Ribot, J., Murano, I., Felipe, F., Cinti, S., Bonet, M. L., & Palou, A. (2006) · Endocrinology · doi:10.1210/en.2006-0760 · Cited by 244
Retinoic Acid Is a High Affinity Selective Ligand for the Peroxisome Proliferator-activated Receptor β/δ
Shaw, N., Elholm, M., & Noy, N. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c300368200 · Cited by 243
Biochemical Properties of Purified Recombinant Human β-Carotene 15,15′-Monooxygenase
Lindqvist, A., & Andersson, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202756200 · Cited by 239
Vitamin A and carotene
Moore, T. S., II (1930) · Biochemical Journal · doi:10.1042/bj0240692 · Cited by 233
Carotenoids and the risk of developing lung cancer: a systematic review
Gallicchio, L. M., Lindsley, K. B., Matanoski, G., Tao, X. G., Chen, L., Lam, T. K., Shiels, M. S., Hammond, E. R., Robinson, K. A., Caulfield, L. E., et al. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.2.372 · Cited by 220
Cloning and Expression of β,β-Carotene 15,15′-Dioxygenase
Wyss, A., Wirtz, G., Woggon, W. ‐., Brugger, R., Wyss, M., Friedlein, A., Bachmann, H., & Hunziker, W. H. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2619 · Cited by 217
Two common single nucleotide polymorphisms in the gene encoding β‐carotene 15,15′‐monoxygenase alter β‐carotene metabolism in female volunteers
Leung, W. C., Hessel, S., Méplan, C., Flint, J. E., Oberhauser, V., Tourniaire, F., Hesketh, J. E., Lintig, J. V., & Lietz, G. (2008) · The FASEB Journal · doi:10.1096/fj.08-121962 · Cited by 213
The Biochemical Characterization of Ferret Carotene-9′, 10′-Monooxygenase Catalyzing Cleavage of Carotenoids in Vitro and in Vivo
Hu, K., Liu, C., Ernst, H., Krinsky, N. I., Russell, R. M., & Wang, X.-D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512095200 · Cited by 212
A Novel Regulatory Pathway of Brown Fat Thermogenesis
Alvarez, R., de Andrés, J., Yubero, P., Viñas, O., Mampel, T., Iglesias, R., Giralt, M., & Villarroya, F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.10.5666 · Cited by 194
Structural Insights into Maize Viviparous14, a Key Enzyme in the Biosynthesis of the Phytohormone Abscisic Acid
Messing, S. A. J., Gabelli, S. B., Echeverria, I., Vogel, J. T., Guan, J., Tan, B. C., Klee, H. J., McCarty, D. R., & Amzel, L. M. (2010) · The Plant Cell · doi:10.1105/tpc.110.074815 · Cited by 180
Crystal structure of native RPE65, the retinoid isomerase of the visual cycle
Kiser, P. D., Golczak, M., Lodowski, D. T., Chance, M. R., & Palczewski, K. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906600106 · Cited by 158
Dietary lycopene and tomato extract supplementations inhibit nonalcoholic steatohepatitis‐promoted hepatocarcinogenesis in rats
Wang, Y., Ausman, L. M., Greenberg, A. S., Russell, R. M., & Wang, X. (2009) · International Journal of Cancer · doi:10.1002/ijc.24689 · Cited by 155
Cloning and Characterization of a Human β,β-Carotene-15, 15′-Dioxygenase That Is Highly Expressed in the Retinal Pigment Epithelium
Yan, W., Jang, G.-F., Haeseleer, F., Esumi, N., Chang, J. T., Kerrigan, M., Campochiaro, M., Campochiaro, P. A., Palczewski, K., & Zack, D. J. (2001) · Genomics · doi:10.1006/geno.2000.6476 · Cited by 154
Changes of Adiposity in Response to Vitamin A Status Correlate with Changes of PPARγ2 Expression
Ribot, J., Felipe, F., Bonet, M. L., & Palou, A. (2001) · Obesity Research · doi:10.1038/oby.2001.65 · Cited by 153
Related enzymes solve evolutionarily recurrent problems in the metabolism of carotenoids
MOISE, A., VONLINTIG, J., & PALCZEWSKI, K. (2005) · Trends in Plant Science · doi:10.1016/j.tplants.2005.02.006 · Cited by 153
Pflanzenfarbstoffe XXV. Über die Konstitution des Lycopins und Carotins
Karrer, P., Helfenstein, A., Wehrli, H., & Wettstein, A. (1930) · Helvetica Chimica Acta · doi:10.1002/hlca.19300130532 · Cited by 150
Expression and Characterization of a Murine Enzyme Able to Cleave β-Carotene
Paik, J., During, A., Harrison, E. H., Mendelsohn, C. L., Lai, K., & Blaner, W. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010086200 · Cited by 150
A nonsense mutation in the beta-carotene oxygenase 2 (BCO2) gene is tightly associated with accumulation of carotenoids in adipose tissue in sheep (Ovis aries)
Våge, D. I., & Boman, I. A. (2010) · BMC Genetics · doi:10.1186/1471-2156-11-10 · Cited by 150
Effects of physiological versus pharmacological beta-carotene supplementation on cell proliferation and histopathological changes in the lungs of cigarette smoke-exposed ferrets
Liu, C. (2000) · Carcinogenesis · doi:10.1093/carcin/21.12.2245 · Cited by 150
β,β-Carotene Decreases Peroxisome Proliferator Receptor γ Activity and Reduces Lipid Storage Capacity of Adipocytes in a β,β-Carotene Oxygenase 1-dependent Manner
Lobo, G. P., Amengual, J., Li, H. N. M., Golczak, M., Bonet, M. L., Palczewski, K., & Lintig, J. V. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.132571 · Cited by 149
Self-citation
Distribution of orally administered β-carotene among lipoproteins in healthy men
Johnson, E., & Russell, R. (1992) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/56.1.128 · Cited by 138
The Carotenase AtCCD1 from Arabidopsis thaliana Is a Dioxygenase
Schmidt, H., Kurtzer, R., Eisenreich, W., & Schwab, W. G. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511668200 · Cited by 138
Provitamin A conversion to retinal via theβ,β-carotene-15,15′-oxygenase (bcox) is essential for pattern formation and differentiation during zebrafish embryogenesis
Lampert, J. M., Holzschuh, J., Hessel, S., Driever, W., Vogt, K., & Lintig, J. V. (2003) · Development · doi:10.1242/dev.00437 · Cited by 137
Enzymatic formation of apo-carotenoids from the xanthophyll carotenoids lutein, zeaxanthin and β-cryptoxanthin by ferret carotene-9′,10′-monooxygenase
Mein, J. R., Dolnikowski, G. G., Ernst, H., Russell, R. M., & Wang, X. (2010) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2010.11.005 · Cited by 135
Low and high responders to pharmacological doses of β-carotene: proportion in the population, mechanisms involved and consequences on β-carotene metabolism
Borel, P., Grolier, P., Mekki, N., Boirie‌, Y., Rochette, Y., Roy, B. L., Alexandre-Gouabau, M. C., Lairon, D., & Azaı̈s-Braesco, V. (1998) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32480-9 · Cited by 135
Asymmetric Cleavage of β-Carotene Yields a Transcriptional Repressor of Retinoid X Receptor and Peroxisome Proliferator-Activated Receptor Responses
Ziouzenkova, O., Orasanu, G., Sukhova, G. K., Lau, E., Berger, J. P., Tang, G., Krinsky, N. I., Dolnikowski, G. G., & Plutzky, J. (2006) · Molecular Endocrinology · doi:10.1210/me.2006-0225 · Cited by 132
In vitro and in vivo induction of brown adipocyte uncoupling protein (thermogenin) by retinoic acid
Puigserver, P., Vázquez, F., Bonet, M. L., Picó, C., & Palou, A. (1996) · Biochemical Journal · doi:10.1042/bj3170827 · Cited by 125
Cell Type-specific Expression of β-Carotene 9', 10'-Monooxygenase in Human Tissues
Lindqvist, A., He, Y.-G., & Andersson, S. (2005) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.5a6705.2005 · Cited by 124
Differentiation of 3T3-F442A Cells into Adipocytes is Inhibited by Retinoic Acid
Kuri‐Harcuch, W. (1982) · Differentiation · doi:10.1111/j.1432-0436.1982.tb01279.x · Cited by 123
Modulation of Resistin Expression by Retinoic Acid and Vitamin A Status
Felipe, F., Bonet, M. L., Ribot, J., & Palou, A. (2004) · Diabetes · doi:10.2337/diabetes.53.4.882 · Cited by 123
Retinal biosynthesis in Eubacteria: in vitro characterization of a novel carotenoid oxygenase from Synechocystis sp. PCC 6803
Ruch, S., Beyer, P., Ernst, H., & Al‐Babili, S. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04460.x · Cited by 120
Apo-10′-lycopenoic acid inhibits lung cancer cell growth in vitro, and suppresses lung tumorigenesis in the A/J mouse model in vivo
Lian, F., Smith, D. E., Ernst, H., Russell, R. M., & Wang, X. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm076 · Cited by 119
RPE65 Is an Iron(II)-dependent Isomerohydrolase in the Retinoid Visual Cycle
Moiseyev, G., Takahashi, Y., Chen, Y., Gentleman, S., Redmond, T. M., Crouch, R. K., & Ma, J.-X. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m508903200 · Cited by 119
The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision
von Lintig, J., Kiser, P. D., Golczak, M., & Palczewski, K. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.01.005 · Cited by 119
Differentiation-dependent expression and localization of the class B type I scavenger receptor in intestine
Cai, S. F., Kirby, R. J., Howles, P. N., & Hui, D. Y. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31613-8 · Cited by 116
Towards a better understanding of carotenoid metabolism in animals
von Lintig, J., Hessel, S., Isken, A., Kiefer, C., Lampert, J. M., Voolstra, O., & Vogt, K. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.11.010 · Cited by 116
Analysis of the blind Drosophila mutant ninaB identifies the gene encoding the key enzyme for vitamin A formation in vivo
Lintig, J. V., Dreher, A., Kiefer, C., Wernet, M. F., & Vogt, K. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.031576398 · Cited by 112
Variability of the conversion of β-carotene to vitamin A in women measured by using a double-tracer study design
Lin, Y., Dueker, S. R., Burri, B. J., Neidlinger, T. R., & Clifford, A. J. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.6.1545 · Cited by 111
Identification of Pathways for Atherosclerosis in Mice
Wang, S. S., Schadt, E. E., Wang, H., Wang, X., Ingram-Drake, L. A., Shi, W., Drake, T. A., & Lusis, A. J. (2007) · Circulation Research · doi:10.1161/circresaha.107.152975 · Cited by 107
Loss-of-Function Mutation in Carotenoid 15,15´-Monooxygenase Identified in a Patient with Hypercarotenemia and Hypovitaminosis A
Lindqvist, A., Sharvill, J., Sharvill, D., & Andersson, S. (2007) · Journal of Nutrition · doi:10.1093/jn/137.11.2346 · Cited by 103
Mutation in Bovine β-Carotene Oxygenase 2 Affects Milk Color
Berry, S., Davis, S. R., Beattie, E. M., Thomas, N., Burrett, A., Ward, H. E., Stanfield, A. M., Biswas, M. G., Ankersmit-Udy, A. E., Oxley, P. E., et al. (2009) · Genetics · doi:10.1534/genetics.109.101741 · Cited by 103
Identification of beta‐carotene 15,15′‐monooxygenase as a peroxisome proliferator‐activated receptor target gene
Boulanger, A., McLemore, P., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Yu, S., Gentleman, S., & Redmond, T. M. (2003) · The FASEB Journal · doi:10.1096/fj.02-0690fje · Cited by 101
Isx Participates in the Maintenance of Vitamin A Metabolism by Regulation of β-Carotene 15,15′-Monooxygenase (Bcmo1) Expression
Seino, Y., Miki, T., Kiyonari, H., Abe, T., Fujimoto, W., Kimura, K., Takeuchi, A., Takahashi, Y., Oiso, Y., Iwanaga, T., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m707928200 · Cited by 100
Induction of cytochrome P450 enzymes and over-generation of oxygen radicals in beta-carotene supplemented rats
Paolini, M. (2001) · Carcinogenesis · doi:10.1093/carcin/22.9.1483 · Cited by 99
R91W mutation in Rpe65 leads to milder early-onset retinal dystrophy due to the generation of low levels of 11-cis-retinal
Samardzija, M., Lintig, J. V., Tanimoto, N., Oberhauser, V., Thiersch, M., Remé, C. E., Seeliger, M. W., Grimm, C., & Wenzel, A. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm304 · Cited by 97
A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development
Choi, M. Y., Romer, A. I., Hu, M. H., Lepourcelet, M., Mechoor, A., Yesilaltay, A., Krieger, M., Gray, P. A., & Shivdasani, R. A. (2006) · Development · doi:10.1242/dev.02537 · Cited by 97
Retinal Biosynthesis in Fungi: Characterization of the Carotenoid Oxygenase CarX fromFusarium fujikuroi
Prado‐Cabrero, A., Scherzinger, D., Ávalos, J., & Al‐Babili, S. (2007) · Eukaryotic Cell · doi:10.1128/ec.00392-06 · Cited by 93
The Drosophila Class B Scavenger Receptor NinaD-I Is a Cell Surface Receptor Mediating Carotenoid Transport for Visual Chromophore Synthesis
Voolstra, O., Kiefer, C., Hoehne, M., Welsch, R., Vogt, K., & von Lintig, J. (2006) · Biochemistry · doi:10.1021/bi060701u · Cited by 91
Keto-Carotenoids Are the Major Metabolites of Dietary Lutein and Fucoxanthin in Mouse Tissues1–3
Yonekura, L., Kobayashi, M., Terasaki, M., & Nagao, A. (2010) · Journal of Nutrition · doi:10.3945/jn.110.126466 · Cited by 90
Lipid sensing and lipid sensors
Grimaldi, P. A. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7278-5 · Cited by 89
NinaB combines carotenoid oxygenase and retinoid isomerase activity in a single polypeptide
Oberhauser, V., Voolstra, O., Bangert, A., Lintig, J. V., & Vogt, K. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807805105 · Cited by 89
Feedback Regulation of β,β-Carotene 15,15′-Monooxygenase by Retinoic Acid in Rats and Chickens
Bachmann, H., Desbarats, A., Pattison, P., Sedgewick, M., Riss, G., Wyss, A., Góralczyk, R., Cardinault, N., Duszka, C., & Grolier, P. (2002) · Journal of Nutrition · doi:10.1093/jn/132.12.3616 · Cited by 85
All-Trans Retinoic Acid Increases Oxidative Metabolism in Mature Adipocytes
Mercader, J., Madsen, L., Felipe, F., Palou, A., Kristiansen, K., & Bonet, M. L. (2007) · Cellular Physiology and Biochemistry · doi:10.1159/000110717 · Cited by 84
Up-regulation of muscle uncoupling protein 3 gene expression in mice following high fat diet, dietary vitamin A supplementation and acute retinoic acid-treatment
Felipe, F., Bonet, M. L., Ribot, J., & Palou, A. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802188 · Cited by 80
Effects of retinoic acid administration and dietary vitamin A supplementation on leptin expression in mice: lack of correlation with changes of adipose tissue mass and food intake
Felipe, F., Mercader, J., Ribot, J., Palou, A., & Bonet, M. L. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.11.014 · Cited by 80
Genome-Wide Association Study Identifies Variants at the IL18 -BCO2 Locus Associated With Interleukin-18 Levels
He, M., Cornelis, M. C., Kraft, P. L., van Dam, R. M., Sun, Q., Laurie, C. C., Mirel, D. B., Chasman, D. I., Ridker, P. M., Hunter, D. J., et al. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.199422 · Cited by 79
Differentiation-dependent expression of retinoid-binding proteins in BFC-1 beta adipocytes.
Zovich, D., Orologa, A., Okuno, M., Kong, L. W., Talmage, D. A., Piantedosi, R., Goodman, D. S., & Blaner, W. S. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49651-8 · Cited by 76
β-Carotene Conversion into Vitamin A in Human Retinal Pigment Epithelial Cells
Chichili, G. R., Nöhr, D., ̈ffer, M. S., Lintig, J. V., & Biesalski, H. K. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-0089 · Cited by 75
Cell Type-specific Expression of β-Carotene 15,15′-Mono-oxygenase in Human Tissues
Lindqvist, A., & Andersson, S. (2004) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215540405200407 · Cited by 75
β-Carotene–vitamin A equivalence in Chinese adults assessed by an isotope dilution technique
Wang, Z., Yin, S., Zhao, X., Russell, R. M., & Tang, G. (2004) · British Journal Of Nutrition · doi:10.1079/bjn20031030 · Cited by 71
Rhodopsin-mediated photosensing in green flagellated algae
Sineshchekov, O. A., & Govorunova, E. G. (1999) · Trends in Plant Science · doi:10.1016/s1360-1385(98)01370-3 · Cited by 71
Down-regulation of intestinal scavenger receptor class B, type I (SR-BI) expression in rodents under conditions of deficient bile delivery to the intestine
Voshol, P. J., Schwarz, M., Rigotti, A., Krieger, M., Groen, A. K., & Kuipers, F. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3560317 · Cited by 66
The eccentric cleavage product of β-carotene, β-apo-13-carotenone, functions as an antagonist of RXRα
Eroglu, A., Hruszkewycz, D. P., Curley, R. W., & Harrison, E. H. (2010) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2010.07.025 · Cited by 66
Hepatic stellate cells are an important cellular site for β-carotene conversion to retinoid
Shmarakov, I. O., Fleshman, M. K., D’Ambrosio, D. N., Piantedosi, R., Riedl, K. M., Schwartz, S. J., Curley, R. W., Lintig, J. V., Rubin, L. P., Harrison, E. H., et al. (2010) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2010.05.010 · Cited by 64
Dietary Lycopene Downregulates Carotenoid 15,15′-Monooxygenase and PPAR-γ in Selected Rat Tissues
Zaripheh, S., Nara, T., Nakamura, M., & Erdman, J. W. (2006) · Journal of Nutrition · doi:10.1093/jn/136.4.932 · Cited by 62
The Distinct Signaling Mechanisms of Microbial Sensory Rhodopsins in Archaea, Eubacteria and Eukarya†
Jung, K. (2007) · Photochemistry and Photobiology · doi:10.1562/2006-03-20-ir-853 · Cited by 60
β‐Carotene and its cleavage enzyme β‐carotene‐15,15′‐oxygenase (CMOI) affect retinoid metabolism in developing tissues
Kim, Y., Wassef, L., Chung, S., Jiang, H., Wyss, A., Blaner, W. S., & Quadro, L. (2011) · The FASEB Journal · doi:10.1096/fj.10-175448 · Cited by 60
A novel extrinsic reference method for assessing the vitamin A value of plant foods
Edwards, A. J., You, C., Swanson, J. E., & Parker, R. S. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/74.3.348 · Cited by 55
All-Trans Retinoic Acid Decreases Murine Adipose Retinol Binding Protein 4 Production
Mercader, J., Granados, N., Bonet, M. L., & Palou, A. (2008) · Cellular Physiology and Biochemistry · doi:10.1159/000149815 · Cited by 52
Loss of Carotene-9′,10'-Monooxygenase Expression Increases Serum and Tissue Lycopene Concentrations in Lycopene-Fed Mice
Ford, N. A., Clinton, S. K., Lintig, J. V., Wyss, A., & Erdman, J. W. (2010) · Journal of Nutrition · doi:10.3945/jn.110.128033 · Cited by 52
In vitro and in vivo characterization of retinoid synthesis from β-carotene
Fierce, Y., Vieira, M. D. M., Piantedosi, R., Wyss, A., Blaner, W. S., & Paik, J. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.02.010 · Cited by 51
Opposing actions of cellular retinol-binding protein and alcohol dehydrogenase control the balance between retinol storage and degradation
Molotkov, A., Ghyselinck, N. B., Chambon, P., & Duester, G. (2004) · Biochemical Journal · doi:10.1042/bj20040621 · Cited by 44
Analysis of the blind Drosophila mutant ninaB identifies the gene encoding the key enzyme for vitamin A formation in vivo
Lintig, J. V., Dreher, A., Kiefer, C., Wernet, M. F., & Vogt, K. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.3.1130 · Cited by 42
Dual isotope test for assessing β-carotene cleavage to vitamin A in humans
Hickenbottom, S. J., Lemke, S. L., Dueker, S. R., Lin, Y., Follett, J. R., Carkeet, C., Buchholz, B. A., Vogel, J. S., & Clifford, A. J. (2002) · European Journal of Nutrition · doi:10.1007/s00394-002-0368-0 · Cited by 42
Lycopene Biodistribution Is Altered in 15,15´-Carotenoid Monooxygenase Knockout Mice3
Lindshield, B., King, J. L., Wyss, A., Góralczyk, R., Lu, C., Ford, N. A., & Erdman, J. W. (2008) · Journal of Nutrition · doi:10.3945/jn.108.099663 · Cited by 41
Tissue‐specific regulation of leptin expression and secretion by all‐trans retinoic acid
Hollung, K., Rise, C. P., Drevon, C. A., & Reseland, J. E. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20047 · Cited by 37
Knockout of the Bcmo1 gene results in an inflammatory response in female lung, which is suppressed by dietary beta-carotene
van Helden, Y. G. J., Heil, S. G., van Schooten, F., Kramer, E., Hessel, S., Amengual, J., Ribot, J., Teerds, K. J., Wyss, A., Lietz, G., et al. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0341-7 · Cited by 32
Self-citation
Biochemical evidence for the tyrosine involvement in cationic intermediate stabilization in mouse β-carotene 15, 15'-monooxygenase
Poliakov, E., Gentleman, S., Chander, P., Cunningham, F. X., Grigorenko, B. L., Nemuhin, A. V., & Redmond, T. M. (2009) · BMC Biochemistry · doi:10.1186/1471-2091-10-31 · Cited by 22
Hepatic stellate cells are an important cellular site for beta -carotene conversion to retinoid
Shmarakov, I. O., Fleshman, M. K., D’Ambrosio, D. N., Piantedosi, R., Riedl, K. M., Schwartz, S., Curley, J. R. W., Lintig, J. V., Rubin, L. P., Harrison, E. H., et al. (2011) · Acta Biologica Cracoviensia. Series Zoologia · Cited by 17
Lipidology
Nishida, I. (1999) · Trends in Plant Science · doi:10.1016/s1360-1385(99)01403-x · Cited by 16
Rhodopsin-mediated photosensing in green flagellated algae
Sineshchekov, O. A., & Govorunova, E. G. (1999) · Trends in Plant Science · doi:10.1016/s1360-1385(99)01409-0 · Cited by 6
The biological activity of carotenoid metabolites
Krinsky, N. I. (2005) · doi:10.52439/ybgs2548 · Cited by 1
New Paradigms for Organic Catalysts: The First Organocatalytic Living Polymerization
Nederberg, F., Connor, E. F., Möller, M., Glauser, T., & Hedrick, J. L. (2001) · Angewandte Chemie International Edition · doi:10.1002/1521-3773(20010716)40:14

Flagged first, then by citations

Research works printed but not linked: 1

Leung, 2008, Two common single nucleotide polymorphisms in the gene encoding {beta}-carotene 15,15′-monoxygenase alter {beta}-carotene metabolism in female volunteers, FASEB J., 23, 1041, 10.1096/fj.08-121962 · DOI

Sorted by citations

Mechanistic Aspects of Carotenoid Biosynthesis
Moise, A. R., Al‐Babili, S., & Wurtzel, E. T. (2013) · Chemical Reviews · doi:10.1021/cr400106y · Cited by 334
Absorption of Vitamin A and Carotenoids by the Enterocyte: Focus on Transport Proteins
Reboul, E. (2013) · Nutrients · doi:10.3390/nu5093563 · Cited by 310
Functions, Therapeutic Applications, and Synthesis of Retinoids and Carotenoids
Álvarez, R., Vaz, B., Gronemeyer, H., & de Lera, Á. R. (2014) · Chemical Reviews · doi:10.1021/cr400126u · Cited by 260
An Overview of Carotenoids, Apocarotenoids, and Vitamin A in Agro‐Food, Nutrition, Health, and Disease
Meléndez‐Martínez, A. J. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201801045 · Cited by 272
Host‐related factors explaining interindividual variability of carotenoid bioavailability and tissue concentrations in humans
Bohn, T., Desmarchelier, C., Dragsted, L. O., Nielsen, C. S., Stahl, W., Rühl, R., Keijer, J., & Borel, P. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600685 · Cited by 259

See all 125

Authors: Lobo, G. P., Amengual, J., Palczewski, G., Babino, D., & von Lintig, J.
Affiliations: Case Western Reserve University (US)
ORCID: Lobo, Glenn P.
Amengual, Jaume
Babino, Darwin
Venue: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Publisher: Elsevier BV
Published: 2012-01
Volume: 1821
Issue: 1
Pages: 78-87
ISSN: 1388-1981 (ISSN-L)
DOI: 10.1016/j.bbalip.2011.04.010
PMC: PMC3162997
OpenAlex: W2046674715
Cited by: 125
References: 125
Citations by year: 2026: 4 · 2025: 6 · 2024: 6 · 2023: 8 · 2022: 6 · 2021: 7 · 2020: 6 · 2019: 5 · 2018: 12 · 2017: 8 · 2016: 10 · 2015: 13 · 2014: 6 · 2013: 14 · 2012: 13
FWCI: 1.01
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Health (EY019641)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
Keywords: carotenoid metabolism, vitamin A, retinoids, intestinal absorption, knockout mouse models, oxidative stress, mitochondrial stress, carotenoid accumulation, dietary carotenoids, carotenoid supplementation
MeSH terms: Animals, Carotenoids, Homeostasis, Humans, Intestinal Absorption, Liver, Mitochondria, Liver, Oxygenases, Vitamin A, Signal Transduction, Mice, Knockout, Oxidative Stress, beta-Carotene 15,15'-Monooxygenase, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Mammalian Carotenoid-oxygenases: Key players for carotenoid function and homeostasis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks