The DOI matches its Crossref record; 192 of the 192 references it cites were found in a registry or an index.
Lysophospholipids and their receptors in the central nervous system
Open accessAbstract
Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), two of the best-studied lysophospholipids, are known to influence diverse biological events, including organismal development as well as function and pathogenesis within multiple organ systems. These functional roles are due to a family of at least 11 G protein-coupled receptors (GPCRs), named LPA1–6 and S1P1–5, which are widely distributed throughout the body and that activate multiple effector pathways initiated by a range of heterotrimeric G proteins including Gi/o, G12/13, Gq and Gs, with actual activation dependent on receptor subtypes. In the central nervous system (CNS), a major locus for these signaling pathways, LPA and S1P have been shown to influence myriad responses in neurons and glial cell types through their cognate receptors. These receptor-mediated activities can contribute to disease pathogenesis and have therapeutic relevance to human CNS disorders as demonstrated for multiple sclerosis (MS) and possibly others that include congenital hydrocephalus, ischemic stroke, neurotrauma, neuropsychiatric disorders, developmental disorders, seizures, hearing loss, and Sandhoff disease, based upon the experimental literature. In particular, FTY720 (fingolimod, Gilenya, Novartis Pharma, AG) that becomes an analog of S1P upon phosphorylation, was approved by the FDA in 2010 as a first oral treatment for MS, validating this class of receptors as medicinal targets. This review will provide an overview and update on the biological functions of LPA and S1P signaling in the CNS, with a focus on results from studies using genetic null mutants for LPA and S1P receptors. This article is part of a Special Issue entitled Advances in Lysophospholipid Research.
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1 retracted
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Self-citationRetractedA Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis
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Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
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Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists
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The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors
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Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis
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Lysophospholipid receptor nomenclature review: IUPHAR Review 8
Kihara, Y., Maceyka, M., Spiegel, S., & Chun, J. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12678 · Cited by 324
Self-citationPruritus in cholestasis: facts and fiction
Beuers, U., Kremer, A. E., Bolier, R., & Elferink, R. P. J. O. (2014) · Hepatology · doi:10.1002/hep.26909 · Cited by 225
Loss of the neuroprotective factor sphingosine 1-phosphate early in Alzheimer’s disease pathogenesis
Couttas, T. A., Kain, N., Daniels, B., Lim, X. Y., Shepherd, C., Kril, J., Pickford, R., Li, H., Garner, B., & Don, A. S. (2014) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-2-9 · Cited by 161
Chun, J., Kihara, Y., Jonnalagadda, D., & Blaho, V. A. (2019) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010818-021358 · Cited by 131
Self-citationPlastira, I., Bernhart, E., Goeritzer, M., Reicher, H., Kumble, V. B., Kogelnik, N., Wintersperger, A., Hammer, A., Schlager, S., Jandl, K., et al. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0701-9 · Cited by 112
Metadata
- Authors
- Choi, J. W., & Chun, J.
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
- Publisher
- Elsevier BV
- Published
- 2013-01
- Volume
- 1831
- Issue
- 1
- Pages
- 20-32
- ISSN
- 1388-1981 (ISSN-L)
- OpenAlex
- W2108906644
- Cited by
- 255
- References
- 192
- FWCI
- 7.09
- Type
- journal article
- Language
- en
- Open access
- green
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