The DOI matches its Crossref record; 212 of the 212 references it cites were found in a registry or an index.
Lysophospholipid receptor nomenclature review: IUPHAR Review 8
Open accessAbstract
Lysophospholipids encompass a diverse range of small, membrane‐derived phospholipids that act as extracellular signals. The signalling properties are mediated by 7‐transmembrane GPCRs, constituent members of which have continued to be identified after their initial discovery in the mid‐1990s. Here we briefly review this class of receptors, with a particular emphasis on their protein and gene nomenclatures that reflect their cognate ligands. There are six lysophospholipid receptors that interact with lysophosphatidic acid (LPA): protein names LPA 1 – LPA6 and italicized gene names LPAR1‐LPAR6 (human) and Lpar1‐Lpar6 (non‐human). There are five sphingosine 1‐phosphate (S1P) receptors: protein names S1P 1‐S1P 5 and italicized gene names S1PR1‐S1PR5 (human) and S1pr1‐S1pr5 (non‐human). Recent additions to the lysophospholipid receptor family have resulted in the proposed names for a lysophosphatidyl inositol (LPI) receptor – protein name LPI 1 and gene name LPIR1 (human) and Lpir1 (non‐human) – and three lysophosphatidyl serine receptors – protein names LyPS 1, LyPS 2, LyPS 3 and gene names LYPSR1‐LYPSR3 (human) and Lypsr1‐Lypsr3 (non‐human) along with a variant form that does not appear to exist in humans that is provisionally named LyPS 2L. This nomenclature incorporates previous recommendations from the International U nion of B asic and C linical P harmacology, the H uman G enome O rganization, the Gene Nomenclature Committee, and the M ouse G enome I nformatix.
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1 retracted
Lysophosphatidic Acid Stimulates the G-protein-coupled Receptor EDG-1 as a Low Affinity Agonist
Lee, M.-J., Thangada, S., Liu, C. H., Thompson, B. D., & Hla, T. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.34.22105 · Cited by 109
RetractedFast, scalable generation of high‐quality protein multiple sequence alignments using Clustal Omega
Sievers, F., Wilm, A., Dineen, D., Gibson, T. J., Karplus, K., Li, W., Lopez, R., McWilliam, H., Remmert, M., Söding, J., et al. (2011) · Molecular Systems Biology · doi:10.1038/msb.2011.75 · Cited by 15,355
G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS
Gilman, A. G. (1987) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.56.070187.003151 · Cited by 6,381
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
Matloubian, M., Lo, C. G., Cinamon, G., Lesneski, M. J., Xu, Y., Brinkmann, V., Allende, M. L., Proia, R. L., & Cyster, J. G. (2004) · Nature · doi:10.1038/nature02284 · Cited by 2,581
Activities at the Universal Protein Resource (UniProt)
(2014) · Nucleic Acids Research · doi:10.1093/nar/gkt1140 · Cited by 1,735
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Brinkmann, V., Davis, M. D., Heise, C. E., Albert, R., Cottens, S., Hof, R., Bruns, C., Prieschl, E., Baumruker, T., Hiestand, P., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200176200 · Cited by 1,504
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Brinkmann, V., Billich, A., Baumruker, T., Heining, P., Schmouder, R., Francis, G., Aradhye, S., & Burtin, P. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3248 · Cited by 1,273
Liu, Y., Wada, R., Yamashita, T., Mi, Y., Deng, C.-X., Hobson, J. P., Rosenfeldt, H. M., Nava, V. E., Chae, S.-S., Lee, M.-J., et al. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10905 · Cited by 1,149
Self-citationObstetric Complications and Schizophrenia: Historical and Meta-Analytic Review
Cannon, M., Jones, P. B., & Murray, R. M. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.7.1080 · Cited by 1,137
Sphingosine-1-phosphate signaling and its role in disease
Maceyka, M., Harikumar, K. B., Milstien, S., & Spiegel, S. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.09.003 · Cited by 1,039
Self-citation
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Salgado-Polo, F., Borza, R., Matsoukas, M.-T., Marsais, F., Jagerschmidt, C., Waeckel, L., Moolenaar, W. H., Ford, P., Heckmann, B., & Perrakis, A. (2023) · Cell Chemical Biology · doi:10.1016/j.chembiol.2022.12.006 · Cited by 45
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Metadata
- Authors
- Kihara, Y., Maceyka, M., Spiegel, S., & Chun, J.
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 2014-07-12
- Volume
- 171
- Issue
- 15
- Pages
- 3575-3594
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- OpenAlex
- W1549006420
- Cited by
- 324
- References
- 212
- FWCI
- 11.44
- Type
- journal article
- Language
- en
- Open access
- bronze
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