The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Formation and functions of the corneocyte lipid envelope (CLE)
Open accessAbstract
Corneocytes in mammalian stratum corneum are surrounded by a monolayer of covalently bound ω-OH-ceramides that form the corneocyte (-bound) lipid envelope (CLE). We review here the structure, composition, and possible functions of this structure, with insights provided by inherited and acquired disorders of lipid metabolism. This article is part of a Special Issue entitled The Important Role of Lipids in the Epidermis and their Role in the Formation and Maintenance of the Cutaneous Barrier. Guest Editors: Kenneth R. Feingold and Peter Elias.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“A portion of EO ceramides are converted into protein-bound hydroxy (P-O) ceramides (Fig. 1B), which are connected to cross-linked proteins constituting the cornified envelope, a structure located beneath the surface of corneocytes (20)(21)(22).”
From Comparative profiling and comprehensive quantification of stratum corneum ceramides in humans and mice by LC/MS/MS (2020) · cites this paper as [21]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Lipoxygenases: Occurrence, Functions, Catalysis, and Acquisition of Substrate
Brash, A. R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.34.23679 · Cited by 1,335
Oji, V., Tadini, G., Akiyama, M., Blanchet‐Bardon, C., Bodemer, C., Bourrat, E., Coudiere, P., DiGiovanna, J. J., Elias, P. M., Fischer, J., et al. (2010) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2009.11.020 · Cited by 781
Self-citationAkiyama, M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24834 · Cited by 392
Mutations in ABCA12 Underlie the Severe Congenital Skin Disease Harlequin Ichthyosis
Kelsell, D. P., Norgett, E. E., Unsworth, H., Teh, M., Cullup, T., Mein, C. A., Dopping-Hepenstal, J. P., Dale, A. B., Tadini, G., Fleckman, P. H., et al. (2005) · The American Journal of Human Genetics · doi:10.1086/429844 · Cited by 351
Lipid and protein structures in the permeability barrier of mammalian epidermis.
Downing, D. T. (1992) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41520-2 · Cited by 316
Jobard, F. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.1.107 · Cited by 278
Schweiger, M., Lass, A., Zimmermann, R., Eichmann, T. O., & Zechner, R. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00099.2009 · Cited by 272
CGI-58 Interacts with Perilipin and Is Localized to Lipid Droplets
Yamaguchi, T., Omatsu, N., Matsushita, S., & Osumi, T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403920200 · Cited by 258
Vasireddy, V., Uchida, Y., Salem, N., Kim, S. Y., Mandal, M. N. A., Reddy, G. B., Bodepudi, R., Alderson, N. L., Brown, J. C., Hama, H., et al. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddl480 · Cited by 247
Self-citationDeficiency of Epidermal Protein-Bound ω-Hydroxyceramides in Atopic Dermatitis
Macheleidt, O., Sandhoff, K., & Kaiser, H. W. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2002.01833.x · Cited by 236
Research works printed but not linked: 1
- Menon, 2011, Abnormalities in ultrastructure of epidermal lamellar bodies and corneocyte lipid envelope in Refsum disease, vol. 131, S52
Cited by
Sorted by citations
Lukić, M. Ž., Pantelić, I., & Savic, S. D. (2021) · Cosmetics · doi:10.3390/cosmetics8030069 · Cited by 474
Role of lipids in the formation and maintenance of the cutaneous permeability barrier
Feingold, K. R., & Elias, P. M. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.11.007 · Cited by 383
Self-citationPermeation enhancers in transdermal drug delivery: benefits and limitations
Kováčik, A., Kopečná, M., & Vávrová, K. (2020) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2020.1713087 · Cited by 372
Multifaceted pathways protect human skin from UV radiation
Natarajan, V. T., Ganju, P., Ramkumar, A., Grover, R., & Gokhale, R. S. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1548 · Cited by 244
Kihara, A. (2016) · Progress in Lipid Research · doi:10.1016/j.plipres.2016.04.001 · Cited by 244
Metadata
- Authors
- Elias, P. M., Gruber, R., Crumrine, D., Menon, G., Williams, M. L., Wakefield, J. S., Holleran, W. M., & Uchida, Y.
- Affiliations
- San Francisco VA Medical Center (US)
- California Academy of Sciences (US)
- University of California, San Francisco (US)
- Corresponding author
- Elias, Peter M.
- ORCID
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
- Publisher
- Elsevier BV
- Published
- 2014-03
- Volume
- 1841
- Issue
- 3
- Pages
- 314-318
- ISSN
- 1388-1981 (ISSN-L)
- PMC
- PMC3943821
- OpenAlex
- W2060531073
- Cited by
- 169
- References
- 32
- Citations by year
- 2026: 7 · 2025: 15 · 2024: 23 · 2023: 17 · 2022: 6 · 2021: 16 · 2020: 16 · 2019: 12 · 2018: 14 · 2017: 13 · 2016: 10 · 2015: 10 · 2014: 9
- FWCI
- 1.21
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR019098, R01AR019098, R01AR061106)
- Topics
- Health Sciences › Medicine › Dermatology › Genetic and rare skin diseases.
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Surface Properties and Treatments
- Keywords
- stratum corneum, ceramide, corneocytes, skin barrier, lipid metabolism disorders, skin barrier function, epidermal lipids
- MeSH terms
- Epidermal Cells, Animals, Epidermis, Humans, Lipids, Lipid Metabolism
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
