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Formation and functions of the corneocyte lipid envelope (CLE)
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Corneocytes in mammalian stratum corneum are surrounded by a monolayer of covalently bound ω-OH-ceramides that form the corneocyte (-bound) lipid envelope (CLE). We review here the structure, composition, and possible functions of this structure, with insights provided by inherited and acquired disorders of lipid metabolism. This article is part of a Special Issue entitled The Important Role of Lipids in the Epidermis and their Role in the Formation and Maintenance of the Cutaneous Barrier. Guest Editors: Kenneth R. Feingold and Peter Elias.
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“A portion of EO ceramides are converted into protein-bound hydroxy (P-O) ceramides (Fig. 1B), which are connected to cross-linked proteins constituting the cornified envelope, a structure located beneath the surface of corneocytes (20)(21)(22).”
From Comparative profiling and comprehensive quantification of stratum corneum ceramides in humans and mice by LC/MS/MS (2020) · cites this paper as [21]
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Cites
Lipoxygenases: Occurrence, Functions, Catalysis, and Acquisition of Substrate
Brash, A. R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.34.23679 · Cited by 1,335
Oji, V., Tadini, G., Akiyama, M., Blanchet‐Bardon, C., Bodemer, C., Bourrat, E., Coudiere, P., DiGiovanna, J. J., Elias, P. M., Fischer, J., et al. (2010) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2009.11.020 · Cited by 781
Self-citationAkiyama, M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24834 · Cited by 392
Mutations in ABCA12 Underlie the Severe Congenital Skin Disease Harlequin Ichthyosis
Kelsell, D. P., Norgett, E. E., Unsworth, H., Teh, M., Cullup, T., Mein, C. A., Dopping-Hepenstal, J. P., Dale, A. B., Tadini, G., Fleckman, P. H., et al. (2005) · The American Journal of Human Genetics · doi:10.1086/429844 · Cited by 351
Lipid and protein structures in the permeability barrier of mammalian epidermis.
Downing, D. T. (1992) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41520-2 · Cited by 316
Jobard, F. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.1.107 · Cited by 278
Schweiger, M., Lass, A., Zimmermann, R., Eichmann, T. O., & Zechner, R. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00099.2009 · Cited by 272
CGI-58 Interacts with Perilipin and Is Localized to Lipid Droplets
Yamaguchi, T., Omatsu, N., Matsushita, S., & Osumi, T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403920200 · Cited by 258
Vasireddy, V., Uchida, Y., Salem, N., Kim, S. Y., Mandal, M. N. A., Reddy, G. B., Bodepudi, R., Alderson, N. L., Brown, J. C., Hama, H., et al. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddl480 · Cited by 247
Self-citationDeficiency of Epidermal Protein-Bound ω-Hydroxyceramides in Atopic Dermatitis
Macheleidt, O., Sandhoff, K., & Kaiser, H. W. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2002.01833.x · Cited by 236
Research works printed but not linked: 1
- Menon, 2011, Abnormalities in ultrastructure of epidermal lamellar bodies and corneocyte lipid envelope in Refsum disease, vol. 131, S52
Cited by
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Lukić, M. Ž., Pantelić, I., & Savic, S. D. (2021) · Cosmetics · doi:10.3390/cosmetics8030069 · Cited by 474
Role of lipids in the formation and maintenance of the cutaneous permeability barrier
Feingold, K. R., & Elias, P. M. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.11.007 · Cited by 383
Self-citationPermeation enhancers in transdermal drug delivery: benefits and limitations
Kováčik, A., Kopečná, M., & Vávrová, K. (2020) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2020.1713087 · Cited by 372
Multifaceted pathways protect human skin from UV radiation
Natarajan, V. T., Ganju, P., Ramkumar, A., Grover, R., & Gokhale, R. S. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1548 · Cited by 244
Kihara, A. (2016) · Progress in Lipid Research · doi:10.1016/j.plipres.2016.04.001 · Cited by 244
Skin lipids in health and disease: A review
Knox, S. E., & O’Boyle, N. M. (2021) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2021.105055 · Cited by 214
Ohno, Y., Nakamichi, S., Ohkuni, A., Kamiyama, N., Naoe, A., Tsujimura, H., Yokose, U., Sugiura, K., Ishikawa, J., Akiyama, M., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1503491112 · Cited by 168
Fingerpad‐Inspired Multimodal Electronic Skin for Material Discrimination and Texture Recognition
Lee, G., Son, J. H., Lee, S., Kim, S. W., Kim, D., Nguyen, N. N., Lee, S. G., & Cho, K. (2021) · Advanced Science · doi:10.1002/advs.202002606 · Cited by 157
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Uchida, Y., & Park, K. (2021) · American Journal of Clinical Dermatology · doi:10.1007/s40257-021-00619-2 · Cited by 141
Self-citationStefanovic, N., & Irvine, A. D. (2023) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2023.09.009 · Cited by 150
PNPLA1 has a crucial role in skin barrier function by directing acylceramide biosynthesis
Hirabayashi, T., tatsuki, A., Kaneko, A., Senoo, Y., Shibata, A., Takama, H., Yokoyama, K., Nishito, Y., Ono, T., Taya, C., et al. (2017) · Nature Communications · doi:10.1038/ncomms14609 · Cited by 137
Kawana, M., Miyamoto, M., Ohno, Y., & Kihara, A. (2020) · Journal of Lipid Research · doi:10.1194/jlr.ra120000671 · Cited by 129
Modelling the Complexity of Human Skin In Vitro
Hofmann, E., Schwarz, A., Fink, J., Kamolz, L.-P., & Kotzbeck, P. (2023) · Biomedicines · doi:10.3390/biomedicines11030794 · Cited by 129
Akiyama, M. (2017) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2017.06.002 · Cited by 113
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Yamamoto, K., Miki, Y., Sato, M., Taketomi, Y., Nishito, Y., Taya, C., Muramatsu, K., Ikeda, K., Nakanishi, H., Taguchi, R., et al. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20141904 · Cited by 106
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Boer, D. E. C., van Smeden, J., Bouwstra, J. A., & Aerts, J. M. F. G. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9030736 · Cited by 105
Kendall, A. C., Kiezel‐Tsugunova, M., Brownbridge, L. C., Harwood, J. L., & Nicolaou, A. (2017) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2017.03.016 · Cited by 101
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Wertz, P. W. (2018) · Journal of Lipids · doi:10.1155/2018/5954034 · Cited by 98
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Grond, S., Eichmann, T. O., Dubrac, S., Kolb, D., Schmuth, M., Fischer, J., Crumrine, D. A., Elias, P. M., Haemmerle, G., Zechner, R., et al. (2016) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2016.08.036 · Cited by 97
Self-citationBerdyshev, E. V., Kim, J., Kim, B. E., Goleva, E., Lyubchenko, T. A., Bronova, I. A., Bronoff, A. S., Xiao, O., Kim, J., Kim, S., et al. (2023) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2023.02.013 · Cited by 91
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Takeichi, T., Hirabayashi, T., Miyasaka, Y., Kawamoto, A., Okuno, Y., Taguchi, S., Tanahashi, K., Murase, C., Takama, H., Tanaka, K., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci130675 · Cited by 89
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Fujii, M. (2021) · Cells · doi:10.3390/cells10092386 · Cited by 86
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Évora, A. S., Adams, M. J., Johnson, S. A., & Zhang, Z. (2021) · Skin Pharmacology and Physiology · doi:10.1159/000513054 · Cited by 83
Epidermal barrier function in dry, flaky and sensitive skin: A narrative review
Fluhr, J. W., Moore, D. J., Lane, M. E., Lachmann, N., & Rawlings, A. V. (2023) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.19745 · Cited by 81
Kim, D. W., Kim, S., & Jeong, U. (2018) · Advanced Materials · doi:10.1002/adma.201804949 · Cited by 64
Yamamoto, H., Hattori, M., Chamulitrat, W., Ohno, Y., & Kihara, A. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1917525117 · Cited by 63
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Boncheva, M. (2014) · International Journal of Cosmetic Science · doi:10.1111/ics.12162 · Cited by 63
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Singla, S., Jain, D., Zoltowski, C. M., Voleti, S., Stark, A. Y., Niewiarowski, P. H., & Dhinojwala, A. (2021) · Science Advances · doi:10.1126/sciadv.abd9410 · Cited by 60
Vávrová, K., Kováčik, A., & Opálka, L. (2017) · European Pharmaceutical Journal · doi:10.1515/afpuc-2017-0004 · Cited by 61
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Schmitt, T., & Neubert, R. H. H. (2018) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2018.09.017 · Cited by 62
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Briganti, S., Mosca, S., Nardo, A. D., Flori, E., & Ottaviani, M. (2024) · Biomolecules · doi:10.3390/biom14060728 · Cited by 60
Pichery, M., Huchenq, A., Sandhoff, R., Severino‐Freire, M., Zaafouri, S., Opálka, L., Levade, T., Soldan, V., Bertrand‐Michel, J., Lhuillier, É., et al. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx079 · Cited by 56
The role of PNPLA1 in ω-O-acylceramide synthesis and skin barrier function
Hirabayashi, T., Murakami, M., & Kihara, A. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2018.09.010 · Cited by 54
Kien, B., Grond, S., Haemmerle, G., Lass, A., Eichmann, T. O., & Radner, F. P. W. (2018) · Journal of Lipid Research · doi:10.1194/jlr.m089771 · Cited by 53
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van Logtestijn, M. D. A., Domínguez‐Hüttinger, E., Stamatas, G. N., & Tanaka, R. J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117292 · Cited by 50
Crumrine, D. A., Khnykin, D., Krieg, P., Man, M., Celli, A., Mauro, T. M., Wakefield, J. S., Menon, G. K., Mauldin, E. A., Miner, J. H., et al. (2018) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2018.11.005 · Cited by 48
Self-citationZalenskaya, I. A., Chandra, N., Yousefieh, N., Fang, X., Adedipe, O. E., Jackson, S. S., Anderson, S. M., Mauck, C. K., Schwartz, J. L., Thurman, A. R., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci120583 · Cited by 46
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van Hoogevest, P., & Fahr, A. (2019) · Springer eBooks · doi:10.1007/978-3-030-16573-4_6 · Cited by 47
Zhang, Y., Zheng, Z., Zhu, S., Xu, L., Zhang, Q., Gao, J., Ye, M., Shen, S., Xing, J., Wu, M., et al. (2025) · Advanced Science · doi:10.1002/advs.202416267 · Cited by 47
Choi, H. K., Cho, Y. H., Lee, E. O., Kim, J. W., & Park, C. S. (2017) · Archives of Dermatological Research · doi:10.1007/s00403-017-1782-8 · Cited by 46
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Berdyshev, E. V. (2024) · Allergy Asthma and Immunology Research · doi:10.4168/aair.2024.16.5.445 · Cited by 44
Karim, N., Phinney, B. S., Salemi, M., Wu, P., Naeem, M., & Rice, R. H. (2019) · Experimental Dermatology · doi:10.1111/exd.13925 · Cited by 44
Therapeutic targeting of the IL-13 pathway in skin inflammation
Tubau, C., & Puig, L. (2020) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2020.1858802 · Cited by 44
Schmitt, T., & Neubert, R. H. H. (2020) · Skin Pharmacology and Physiology · doi:10.1159/000509019 · Cited by 43
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Kim, S.-N., Akindehin, S., Kwon, H.-J., Son, Y.-H., Saha, A., Jung, Y.-S., Seong, J. K., Lim, K., Sung, J.-H., Maddipati, K. R., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-27221-7 · Cited by 43
Phospholipase A2 in skin biology: new insights from gene-manipulated mice and lipidomics
Murakami, M., Yamamoto, K., & Taketomi, Y. (2018) · Inflammation and Regeneration · doi:10.1186/s41232-018-0089-2 · Cited by 42
Moskot, M., Bocheńska, K., Jakóbkiewicz‐Banecka, J., Banecki, B., & Gabig‐Cimińska, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19010247 · Cited by 42
Miyamoto, M., Itoh, N., Sawai, M., Sassa, T., & Kihara, A. (2019) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2019.07.689 · Cited by 40
Neubert, R. H. H. (2024) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2024.114394 · Cited by 38
Revol-Cavalier, J., Quaranta, A., Newman, J. W. I., BRASH, A. R., Hámberg, M., & Wheelock, C. E. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00520 · Cited by 46
Chiba, T., Thomas, C. P., Calcutt, M. W., Boeglin, W. E., O’Donnell, V. B., & BRASH, A. R. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.711267 · Cited by 37
Gruber, R. W., Sugarman, J. L., Crumrine, D. A., Hupe, M., Mauro, T. M., Mauldin, E. A., Thyssen, J. P., Brandner, J. M., Hennies, H.-C., Schmuth, M., et al. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2014.12.012 · Cited by 37
Self-citationMerleev, A. A., Le, S. T., Alexanian, C. C., Toussi, A. M., Xie, Y., Marusina, A. I., Watkins, S. M., Patel, F., Billi, A. C., Wiedemann, J., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.159762 · Cited by 36
Zhang, L., Ferreyros, M., Feng, W., Hupe, M., Crumrine, D. A., Chen, J., Elias, P. M., Holleran, W. M., Niswander, L. A., Hohl, D., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0161465 · Cited by 35
Self-citationSchild, J., Kalvodová, A., Zbytovská, J., Farwick, M., & Pyko, C. (2024) · International Journal of Cosmetic Science · doi:10.1111/ics.12972 · Cited by 47
Grond, S., Radner, F. P. W., Eichmann, T. O., Kolb, D., Grabner, G. F., Wolinski, H., Gruber, R. W., Hofer, P., Heier, C., Schauer, S., et al. (2016) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2016.09.025 · Cited by 34
Self-citationSochorová, M., Staňková, K., Pullmannová, P., Kováčik, A., Zbytovská, J., & Vávrová, K. (2017) · Scientific Reports · doi:10.1038/s41598-017-06990-7 · Cited by 32
Sallam, M. A., Prakash, S., Kumbhojkar, N., Shields, C. W., & Mitragotri, S. (2021) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10215 · Cited by 34
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Self-citationLin, M., Hsu, F., Crumrine, D. A., Meyer, J. M., Elias, P. M., & Miner, J. H. (2019) · Scientific Reports · doi:10.1038/s41598-019-49684-y · Cited by 32
Self-citationNiehues, H., van Vlijmen‐Willems, I. M. J. J., Bergboer, J. G. M., Kersten, F. F. J., Narita, M., Hendriks, W. J. A. J., van den Bogaard, E. H. J., Zeeuwen, P. L. J. M., & Schalkwijk, J. (2015) · British Journal of Dermatology · doi:10.1111/bjd.14284 · Cited by 32
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Akiyama, M. (2020) · FEBS Journal · doi:10.1111/febs.15497 · Cited by 28
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Pullmannová, P., Ermakova, E. V., Kováčik, A., Opálka, L., Maixner, J., Zbytovská, J., Kučerka, N., & Vávrová, K. (2019) · Journal of Lipid Research · doi:10.1194/jlr.m090977 · Cited by 27
Chiba, T., Nakahara, T., Kohda, F., Ichiki, T., Manabe, M., & Furue, M. (2019) · PLoS ONE · doi:10.1371/journal.pone.0210013 · Cited by 27
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Ohno, Y., Nakamura, T., Iwasaki, T., Katsuyama, A., Ichikawa, S., & Kihara, A. (2023) · iScience · doi:10.1016/j.isci.2023.108248 · Cited by 25
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Gutowska‐Owsiak, D., Podobas, E. I., Eggeling, C., Ogg, G. S., & de la Serna, J. B. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.573230 · Cited by 23
Bielfeldt, S., Bonnier, F., Byrne, H. J., Chourpa, I., Dancik, Y., Lane, M. E., Lunter, D. J., Munnier, E., Puppels, G. J., Tfayli, A. M., et al. (2022) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2022.116709 · Cited by 26
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Marenholz, I., Esparza-Gordillo, J., & Lee, Y. (2015) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0000000000000194 · Cited by 23
Lemaire, G., Olivero, M., Rouquet, V., Moga, A., Pagnon-Minot, A., Cenizo, V., & Portes, P. (2023) · PLoS ONE · doi:10.1371/journal.pone.0268384 · Cited by 22
Simoniello, P., Wiedemann, J., Zink, J., Thönnes, E., Stange, M., Layer, P. G., Kovács, M., Podda, M., Durante, M., & Fournier, C. (2016) · Frontiers in Oncology · doi:10.3389/fonc.2015.00294 · Cited by 20
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Self-citationYamamoto, M., Sassa, T., Kyono, Y., Uemura, H., Kugo, M., Hayashi, H., Imai, Y., Yamanishi, K., & Kihara, A. (2021) · The Journal of Dermatology · doi:10.1111/1346-8138.15725 · Cited by 18
Shin, K., Lim, C. J., Park, H. Y., Kim, S., Kim, B., Lee, Y., Chung, H.-J., Jeong, S., Park, K., & Park, K. (2020) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2019.12.021 · Cited by 17
Akiyama, F., Takahashi, N., Ueda, Y., Tada, S., Takeuchi, N., Ohno, Y., & Kihara, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158291 · Cited by 18
Boiten, W. A., Helder, R. W. J., van Smeden, J., & Bouwstra, J. A. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2019.05.003 · Cited by 16
Tomonaga, N., Manabe, Y., Aida, K., & Sugawara, T. (2020) · Scientific Reports · doi:10.1038/s41598-020-70888-0 · Cited by 16
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Metadata
- Authors
- Elias, P. M., Gruber, R., Crumrine, D., Menon, G., Williams, M. L., Wakefield, J. S., Holleran, W. M., & Uchida, Y.
- Affiliations
- San Francisco VA Medical Center (US)
- California Academy of Sciences (US)
- University of California, San Francisco (US)
- Corresponding author
- Elias, Peter M.
- ORCID
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
- Publisher
- Elsevier BV
- Published
- 2014-03
- Volume
- 1841
- Issue
- 3
- Pages
- 314-318
- ISSN
- 1388-1981 (ISSN-L)
- PMC
- PMC3943821
- OpenAlex
- W2060531073
- Cited by
- 169
- References
- 32
- Citations by year
- 2026: 7 · 2025: 15 · 2024: 23 · 2023: 17 · 2022: 6 · 2021: 16 · 2020: 16 · 2019: 12 · 2018: 14 · 2017: 13 · 2016: 10 · 2015: 10 · 2014: 9
- FWCI
- 1.21
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR019098, R01AR019098, R01AR061106)
- Topics
- Health Sciences › Medicine › Dermatology › Genetic and rare skin diseases.
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Surface Properties and Treatments
- Keywords
- stratum corneum, ceramide, corneocytes, skin barrier, lipid metabolism disorders, skin barrier function, epidermal lipids
- MeSH terms
- Epidermal Cells, Animals, Epidermis, Humans, Lipids, Lipid Metabolism
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