Cited by 225Lipid metabolism and biosynthesisAlgal biology and biofuel productionMicrobial Metabolic Engineering and Bioproduction

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Stress-induced neutral lipid biosynthesis in microalgae — Molecular, cellular and physiological insights

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Zienkiewicz, Krzysztof, Du, Zhi-Yan, Ma, Wei, Vollheyde, Katharina, Benning, Christoph·2016·Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

DOI 10.1016/j.bbalip.2016.02.008

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Abstract

Photosynthetic microalgae have promise as biofuel feedstock. Under certain conditions, they produce substantial amounts of neutral lipids, mainly in the form of triacylglycerols (TAGs), which can be converted to fuels. Much of our current knowledge on the genetic and molecular basis of algal neutral lipid metabolism derives mainly from studies of plants, i.e. seed tissues, and to a lesser extent from direct studies of algal lipid metabolism. Thus, the knowledge of TAG synthesis and the cellular trafficking of TAG precursors in algal cells is to a large extent based on genome predictions, and most aspects of TAG metabolism have yet to be experimentally verified. The biofuel prospects of microalgae have raised the interest in mechanistic studies of algal TAG biosynthesis in recent years and resulted in an increasing number of publications on lipid metabolism in microalgae. In this review we summarize the current findings on genetic, molecular and physiological studies of TAG accumulation in microalgae. Special emphasis is on the functional analysis of key genes involved in TAG synthesis, molecular mechanisms of regulation of TAG biosynthesis, as well as on possible mechanisms of lipid droplet formation in microalgal cells. This article is part of a Special Issue entitled: Plant Lipid Biology edited by Kent D. Chapman and Ivo Feussner.

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A look at diacylglycerol acyltransferases (DGATs) in algae
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High-efficiency nuclear transformation of the diatom Phaeodactylum tricornutum by electroporation
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ABI4 Activates DGAT1 Expression in Arabidopsis Seedlings during Nitrogen Deficiency
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Identification and characterization of an acyl-CoA:diacylglycerol acyltransferase 2 (DGAT2) gene from the microalga O. tauri
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Methylcrotonyl-CoA Carboxylase Regulates Triacylglycerol Accumulation in the Model Diatom Phaeodactylum tricornutum
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Cloning and molecular characterization of a novel acyl‐CoA:diacylglycerol acyltransferase 1‐like gene (PtDGAT1) from the diatom Phaeodactylum tricornutum
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Physiological and molecular analysis of carbon source supplementation and pH stress-induced lipid accumulation in the marine diatom Phaeodactylum tricornutum
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Highly Efficient Transformation of the DiatomPhaeodactylum tricornutumby Multi-Pulse Electroporation
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Isolation of a Novel Oil Globule Protein from the Green Alga Haematococcus pluvialis (Chlorophyceae)
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Dynamics of protein and polar lipid recruitment during lipid droplet assembly in Chlamydomonas reinhardtii
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Transcriptional coordination of physiological responses in N annochloropsis oceanica CCMP 1779 under light/dark cycles
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Enzyme activity highlights the importance of the oxidative pentose phosphate pathway in lipid accumulation and growth of Phaeodactylum tricornutum under CO2 concentration
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Recruiting a New Substrate for Triacylglycerol Synthesis in Plants: The Monoacylglycerol Acyltransferase Pathway
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Identification and localization of a caleosin in olive (Olea europaea L.) pollen during in vitro germination
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Lipid production in Nannochloropsis gaditana is doubled by decreasing expression of a single transcriptional regulator
Ajjawi, I., Verruto, J., Aqui, M., Soriaga, L. B., Coppersmith, J. L., Kwok, K., Peach, L., Orchard, E. D., Kalb, R., Xu, W., et al. (2017) · Nature Biotechnology · doi:10.1038/nbt.3865 · Cited by 481
The lipid biochemistry of eukaryotic algae
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Nzayisenga, J. C., Farge, X., Groll, S. L., & Sellstedt, A. (2020) · Biotechnology for Biofuels · doi:10.1186/s13068-019-1646-x · Cited by 347
Plant Lipid Droplets and Their Associated Proteins: Potential for Rapid Advances
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Current trends to comprehend lipid metabolism in diatoms
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Authors: Zienkiewicz, K., Du, Z.-Y., Ma, W., Vollheyde, K., & Benning, C.
Affiliations: University of Göttingen (DE)
Michigan State University (US)
Great Lakes Bioenergy Research Center (US)
ORCID: Zienkiewicz, Krzysztof
Du, Zhi-Yan
Ma, Wei
Vollheyde, Katharina
Venue: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Publisher: Elsevier BV
Published: 2016-09
Volume: 1861
Issue: 9
Pages: 1269-1281
ISSN: 1388-1981 (ISSN-L)
DOI: 10.1016/j.bbalip.2016.02.008
OpenAlex: W2258753467
Cited by: 225
References: 148
Citations by year: 2026: 15 · 2025: 12 · 2024: 23 · 2023: 17 · 2022: 10 · 2021: 30 · 2020: 38 · 2019: 24 · 2018: 21 · 2017: 30 · 2016: 5
FWCI: 3.32
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (am, 327 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (acceptedVersion)
PubMed (publishedVersion)
OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
GRO (submittedVersion)
Funders: Center for Advanced Biofuels Systems (DE-SC0001295)
U.S. Department of Energy, Office of Basic Energy Sciences (DE-SC0001295)
U.S Department of Energy, Office of Basic Energy Sciences (DE-FG02-98ER20305)
US National Science Foundation (MCB-0741395, MCB-1515169)
US Department of Energy-Great Lakes Bioenergy Research Center Cooperative Agreement (DE-FC02-07ER64494)
US Air Force Office of Scientific Research (FA9550-11-1-0264)
Michigan State University AgBioResearch
Marie Curie International Outgoing Fellowship within the EU 7th Framework Program AlgaeOilSynth (627266, FP7-PEOPLE-2013-IOF)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
Keywords: microalgae, triglyceride synthesis, stress response, lipid droplet formation, lipid metabolism, biofuel feedstock
MeSH terms: Fatty Acids, Lipids, Photosynthesis, Triglycerides, Genome, Plant, Lipid Metabolism, Biofuels, Microalgae

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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Stress-induced neutral lipid biosynthesis in microalgae — Molecular, cellular and physiological insights

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