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The HDL proteome watch: compilation of studies leads to new insights on HDL function

Davidson, W. Sean, Shah, Amy S., Sexmith, Hannah, Gordon, Scott M.·2022·Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
DOI 10.1016/j.bbalip.2021.159072PMC PMC8715479
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  • In plasma, ApoA1 is the main protein component of HDL and associates with a wide range of proteins that alter its function and metabolism.

    “In plasma, ApoA1 is the main protein component of HDL and is known to associate with a wide range of proteins that alter its function and metabolism (51, 69).”

    From Lipidome and proteome of astrocyte and microglia ApoE lipoprotein reveal differences based on cell type and ApoE isoform (2026) · cites this paper as [51]

    The Introduction identifies APOA1 as a dominant HDL protein and describes many other proteins in human HDL. The Lipid transport section says APOA1 is a structural scaffold on almost all HDL particles and interacts with lipid-remodeling factors. The paper describes effects of other proteins on HDL function and particle clearance, but these passages do not establish that a wide range of proteins alter APOA1’s own function and metabolism. (LLM, conf=0.82)

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Cited by

Sorted by citations

Authors
Davidson, W. S., Shah, A. S., Sexmith, H., & Gordon, S. M.
Venue
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Publisher
Elsevier BV
Published
2022-02
Volume
1867
Issue
2
Pages
159072
ISSN
1388-1981
DOI
10.1016/j.bbalip.2021.159072
PMC
PMC8715479
Cited by
107
References
3
Language
en
Licence

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