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Enterically derived high-density lipoprotein restrains liver injury through the portal vein
Abstract
Intestinal HDL is hepatoprotective: High-density lipoprotein (HDL) is important for cholesterol metabolism and may have anti-inflammatory and antimicrobial properties. Although HDL is mainly produced by the liver, the intestine is also a source. Han et al. show in mice that intestinal HDL is not routed to the systemic circulation. Rather, in the form of HDL3, it is directly transported to the liver through the hepatic portal vein. There, it sequesters bacterial lipopolysaccharide from the gut that can trigger inflammation and liver damage. In various models of liver injury, loss of enteric HDL exacerbated pathology. By contrast, drugs elevating intestinal HDL improved disease outcomes. HDL3 is enriched in human portal venous blood, suggesting that enteric HDL may be targetable for the treatment of liver disease. Science , abe6729, this issue p. eabe6729
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In plasma, ApoA1 is the main protein component of HDL and associates with a wide range of proteins that alter its function and metabolism.
“In plasma, ApoA1 is the main protein component of HDL and is known to associate with a wide range of proteins that alter its function and metabolism (51, 69).”
From Lipidome and proteome of astrocyte and microglia ApoE lipoprotein reveal differences based on cell type and ApoE isoform (2026) · cites this paper as [69]
The Results section on portal HDL3 (page unavailable) reports many accessory proteins in plasma HDL, and the Discussion links LBP-containing HDL3 to an anti-inflammatory function. Our copy does not establish that ApoA1 itself directly associates with that wide range of proteins, that those proteins alter its metabolism, or that ApoA1 is HDL’s main protein component. (LLM, conf=0.85)
Experimental — accuracy not yet measuredLPS-binding protein can transfer LPS to CD14 to initiate inflammatory Toll-like receptor 4/myeloid differentiation factor 2 signaling.
“LPS-binding protein, which can transfer LPS to CD14 to initiate inflammatory Toll-like receptor 4/myeloid differentiation factor 2 signaling”
From Lipidome and proteome of astrocyte and microglia ApoE lipoprotein reveal differences based on cell type and ApoE isoform (2026) · cites this paper as [69]
LPS-binding protein becomes anti-inflammatory when associated with ApoA1-containing HDL.
“becomes anti-inflammatory when associated with ApoA1-containing HDL (69, 99, 100).”
From Lipidome and proteome of astrocyte and microglia ApoE lipoprotein reveal differences based on cell type and ApoE isoform (2026) · cites this paper as [69]
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“Where specified, mice were given HFD or ALD to induce liver inflammation and injury (48, 49).”
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Metadata
- Authors
- Han, Y.-H., Onufer, E. J., Huang, L.-H., Sprung, R. W., Davidson, W. S., Czepielewski, R. S., Wohltmann, M., Sorci-Thomas, M. G., Warner, B. W., & Randolph, G. J.
- Affiliations
- Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA.
- Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
- Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
- Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45237, USA.
- Department of Medicine, Division of Endocrinology, Pharmacology and Toxicology, and Blood Research Institute, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
- ORCID
- Venue
- Science
- Published
- 2021-07-23
- Volume
- 373
- Issue
- 6553
- ISSN
- 0036-8075
- 1095-9203
- PMC
- PMC8478306
- Cited by
- 210
- References
- 4
- Language
- en
- Funders
- National Institutes of Health (DP1DK1109668, AI0499653, T32 DK077653, NIH RO1 HL127649, HL138908, P30 DK052574, NIGMS P41 GM103422, R24GM136766, DK119147)
- NIH Office of the Director (DP1DK1109668, AI0499653, T32 DK077653)
- Norsk Revmatikerforbund (NIH T32DK077653)
- NIH (NIH R01 DK119147, DP1DK1109668, AI0499653, NIH RO1 HL127649, HL138908)
- Work (NIH R01DK119147, AI0499653)
- Lawrence Pakula MD IBD Research Fellowship (NIH RO1HL127649)
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