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To bind zinc or not to bind zinc: An examination of innovative approaches to improved metalloproteinase inhibition
Open accessAbstract
This short review highlights some recent advances in matrix metalloproteinase inhibitor (MMPi) design and development. Three distinct approaches to improved MMP inhibition are discussed: (1) the identification and investigation of novel zinc-binding groups (ZBGs), (2) the study of non-zinc-binding MMPi, and (3) mechanism-based MMPi that form covalent adducts with the protein. Each of these strategies is discussed and their respective advantages and remaining challenges are highlighted. The studies discussed here bode well for the development of ever more selective, potent, and well-tolerated MMPi for treating several important disease pathologies.
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Citations
Cites
New functions for the matrix metalloproteinases in cancer progression
Egeblad, M., & Werb, Z. (2002) · Nature Reviews Cancer · doi:10.1038/nrc745 · Cited by 6,108
Cited by
Biochemical and Biological Attributes of Matrix Metalloproteinases
Cui, N., Hu, M., & Khalil, R. A. (2017) · Progress in Molecular Biology and Translational Science · doi:10.1016/bs.pmbts.2017.02.005 · Cited by 1,359
Structure and Function of Human Matrix Metalloproteinases
Laronha, H., & Caldeira, J. (2020) · Cells · doi:10.3390/cells9051076 · Cited by 609
Zhang, H., Chang, M., Hansen, C. N., Basso, D. M., & Noble-Haeusslein, L. J. (2011) · Neurotherapeutics · doi:10.1007/s13311-011-0038-0 · Cited by 163
New strategies for targeting matrix metalloproteinases.
Fields, G. B. (2015) · Matrix Biology · doi:10.1016/j.matbio.2015.01.002 · Cited by 98
Matrix Metalloproteinases as New Targets in Alzheimer’s Disease: Opportunities and Challenges
Zipfel, P., Rochais, C., Baranger, K., Rivera, S., & Dallemagne, P. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c00352 · Cited by 94
Metadata
- Authors
- Jacobsen, J. A., Major Jourden, J. L., Miller, M. T., & Cohen, S. M.
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Publisher
- Elsevier BV
- Published
- 2010-01
- Volume
- 1803
- Issue
- 1
- Pages
- 72-94
- ISSN
- 0167-4889 (ISSN-L)
- OpenAlex
- W1998954104
- Cited by
- 313
- References
- 1
- FWCI
- 4.08
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Jacobsen, J. A., Major Jourden, J. L., Miller, M. T., & Cohen, S. M. (2010). To bind zinc or not to bind zinc: An examination of innovative approaches to improved metalloproteinase inhibition. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. https://doi.org/10.1016/j.bbamcr.2009.08.006
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
