New functions for the matrix metalloproteinases in cancer progression
Abstract
Matrix metalloproteinases (MMPs) have long been associated with cancer-cell invasion and metastasis. This provided the rationale for clinical trials of MMP inhibitors, unfortunately with disappointing results. We now know, however, that the MMPs have functions other than promotion of invasion, have substrates other than components of the extracellular matrix, and that they function before invasion in the development of cancer. With this knowledge in hand, can we rethink the use of MMP inhibitors in the clinic?
Integrity signals
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Claims the paper makes
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Each is checked against this paper’s own text: does it say what the citing paper says it does?
MMPs generate growth-promoting and cytostatic signals.
“they also generate growth-promoting and cytostatic signals.”
From Inflammation and cancer (2002) · cites this paper as [64]
The efficacy of MMP inhibitors may be mediated, at least in part, through anti-inflammatory actions.
“Thus, the efficacy of MMP inhibitors may be mediated, at least in part, through anti-inflammatory actions64,65.”
From Inflammation and cancer (2002) · cites this paper as [64]
MMPs may mediate many of the actions of inflammatory cells in neoplasms.
“Indeed, MMPs may mediate many of the actions of inflammatory cells in neoplasms64.”
From Inflammation and cancer (2002) · cites this paper as [64]
MMPs produce fragments of basement-membrane collagens and plasminogen that are angiogenesis inhibitors.
“but also produce fragments of basement-membrane collagens and plasminogen that are angiogenesis inhibitors.”
From Inflammation and cancer (2002) · cites this paper as [64]
MMPs activate angiogenesis.
“MMPs activate angiogenesis”
From Inflammation and cancer (2002) · cites this paper as [64]
MMPs have both apoptotic and anti-apoptotic actions.
“They have both apoptotic and anti-apoptotic actions.”
From Inflammation and cancer (2002) · cites this paper as [64]
MMPs can recruit inflammatory cells by releasing chemoattractants and motogens.
“MMPs can recruit inflammatory cells by releasing chemoattractants and motogens;”
From Inflammation and cancer (2002) · cites this paper as [64]
Cancer cell invasion and metastasis have long been facilitated by matrix metalloproteinases (MMPs), whose expression and activation have risen in nearly all human malignancies.
“Cancer cell invasion and metastasis have long been facilitated by matrix metalloproteinases (MMPs), whose expression and activation have risen in nearly all human malignancies.144”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [144]
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References 158 · Cited by 6,108
- Authors
- Egeblad, M., & Werb, Z.
- Affiliations
- University of California, San Francisco (US)
- Venue
- Nature Reviews Cancer
- Published
- 2002-03
- Volume
- 2
- Issue
- 3
- Pages
- 161-174
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W2003500892
- Cited by
- 6,108
- References
- 158
- Citations by year
- 2026: 71 · 2025: 118 · 2024: 116 · 2023: 191 · 2022: 201 · 2021: 211 · 2020: 229 · 2019: 221 · 2018: 305 · 2017: 315 · 2016: 274 · 2015: 300 · 2014: 327 · 2013: 367 · 2012: 360
- FWCI
- 15.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
- Funders
- National Cancer Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Health Sciences › Medicine › Oncology › Peptidase Inhibition and Analysis
- Keywords
- matrix metalloproteinases, tumor progression, tumor invasion, metastasis, matrix metalloproteinase inhibitors, extracellular matrix, carcinogenesis
- MeSH terms
- Cell Transformation, Neoplastic, Humans, Neoplasms, Disease Progression, Matrix Metalloproteinases
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