The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
TRAP-1, the mitochondrial Hsp90
Open accessAbstract
Protein folding quality control does not occur randomly in cells, but requires the action of specialized molecular chaperones compartmentalized in subcellular microenvironments and organelles. Fresh experimental evidence has now linked a mitochondrial-specific Heat Shock Protein-90 (Hsp90) homolog, Tumor Necrosis Factor Receptor-Associated Protein-1 (TRAP-1) to pleiotropic signaling circuitries of organelle integrity and cellular homeostasis. TRAP-1-directed compartmentalized protein folding is broadly exploited in cancer and neurodegenerative diseases, presenting new opportunities for therapeutic intervention in humans.
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Cites
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Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1
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HSP90 and the chaperoning of cancer
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Baines, C. P., Kaiser, R. A., Purcell, N. H., Blair, N. S., Osinska, H., Hambleton, M. A., Brunskill, E. W., Sayen, M. R., Gottlieb, R. A., Dorn, G. W., et al. (2005) · Nature · doi:10.1038/nature03434 · Cited by 2,280
HSP90 at the hub of protein homeostasis: emerging mechanistic insights
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The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore
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PINK1 Protects against Oxidative Stress by Phosphorylating Mitochondrial Chaperone TRAP1
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Signaling the mitochondrial unfolded protein response
Pellegrino, M. W., Nargund, A. M., & Haynes, C. M. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.02.019 · Cited by 359
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Metadata
- Authors
- Altieri, D. C., Stein, G. S., Lian, J. B., & Languino, L. R.
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 1823
- Issue
- 3
- Pages
- 767-773
- ISSN
- 0167-4889 (ISSN-L)
- OpenAlex
- W2031043716
- Cited by
- 186
- References
- 9
- FWCI
- 5.17
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
